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Why We Have Sex: It's Cleansing
LiveScience.com ^ | 3/2/06 | Ker Than

Posted on 03/02/2006 2:12:21 PM PST by anymouse

Scientists have long wondered why organisms bother with sexual reproduction. It makes a whole lot more sense to just have a bunch of females that can clone themselves, which is how asexual reproduction works.

Turns out sex might have evolved as a way to concentrate lots of harmful mutations into individual organisms so they could be easily weeded out by natural selection, a new computer model suggests.

The classic explanation for the onset of whoopee, about 1 billion years ago, is that it provides a way for organisms to swap and shuffle genes and to create offspring with new gene combinations that might survive if the environment suddenly changes.

But some scientists think this isn't enough of a justification to outweigh the many costs of getting together to make little ones. Just ask any single person—sexual organisms have to spend valuable time and resources finding and attracting mates.

If all organisms were like starfishes and cacti, which just drop pieces of themselves when they want to multiply, reproduction would be a whole lot simpler. There would be no need for elaborate peacock feathers or bird songs; stags wouldn't need antlers; elephant bulls wouldn't have to produce stinky cologne and guys probably wouldn't spend so much money on dates.

Natural cleansing

The new work could help test a hypothesis first proposed nearly 20 years ago, stating that sex evolved as a way to purge harmful mutations from a population. According to this view, the random shuffling of genes through sex will sometimes have the effect of concentrating many harmful mutations into single individuals.

These individuals will be less healthy than their peers, and therefore more likely to be weeded out by natural selection, the thinking goes.

This hypothesis, called the "mutational deterministic hypothesis," is controversial though, because it assumes that single mutations by themselves are only slightly harmful, while a combination of many mutations together is much more damaging. Scientists call this phenomenon "negative epistasis."

If negative epistasis were true, it would provide a powerful explanation for why sex has managed to persist for so long despite its numerous costs. But the phenomenon has yet to be widely demonstrated in nature and scientists have yet to figure out how such a thing evolved in the first place.

A new computer model by Ricardo Azevedo of the University of Houston and colleagues provides a possible answer to this last question. According to their model, detailed in the March 2 issue of the journal Nature, negative epistasis is a natural byproduct of sex itself.

Digital critters

The researchers created digital organisms that reproduced through sex in the same manner as real organisms. And like a regular organism, the virtual one developed a natural buffer to resist change by mutations. This ability, called "genetic robustness," is thought to be one of the main benefits of sex.

By shuffling genes, sex allows a population to spread its mutations across many individuals within a group. The mutations become diluted and can be effectively dealt with by an individual's genetic repair system.

But the researchers found that the protection only works when the digital organisms were facing a few mutations at a time. When assaulted by many at once, their repair systems became overwhelmed and the organisms died. Azevedo think this happens in real life, too.

"Most organisms are never forced to adapt to being resistant to many mutations at once," he told LiveScience. "They're adapting to being resistant to one or maybe two mutations, but not to ten at the same time."

The researchers think that the combination of genetic robustness through sex and the limited ability of organisms to deal with mutations leads to the natural development of negative epistasis.

"Most mutations are actually harmful, so anything that helps populations get rid of their harmful mutations is going to be important," Azevedo said. "The more interesting side of evolution is all the beneficial mutations that leads to complex structures, but the dirty work of evolution is to get rid of bad mutations, and that's where sex seems to play a role."


TOPICS:
KEYWORDS: biology; computer; computermodeling; crevolist; data; datamodeling; environment; evolution; genetics; metadata; model; mutation; science; sex
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To: anymouse

HOw about this hypothesis - Sex has survived for so long because it feels so damn good!!!!


41 posted on 03/02/2006 2:31:38 PM PST by commish (Freedom Tastes Sweetest to Those Who Have Fought to Preserve It)
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To: Tijeras_Slim

"In charge?"

You got that right.


42 posted on 03/02/2006 2:32:15 PM PST by Warren_Piece (Smart is easy. Good is hard.)
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To: anymouse

Article has several flaws:
1. Sexual reprodution has no survival advantage over non-sexual reprodution. In fact, in a desert, the cactus may be the best survivor.
2. The article bases its 'coup-de-grace' (spelling?) on a computer model. A computer model is only as good as the program. And do any of us REALLY know all the variables that go into this complex phenomenon, so as to be able to put it into a program?


43 posted on 03/02/2006 2:32:25 PM PST by razoroccam (Then in the name of Allah, they will let loose the Germs of War (http://www.booksurge.com))
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To: commish

http://www.forbes.com/2003/10/08/cz_af_1008health_print.html


44 posted on 03/02/2006 2:32:41 PM PST by Howlin ("Quick, he's bleeding! Is there a <strike>doctor</strike> reporter in the house?")
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To: Mike Bates

And here I thought you pinged me to this because my pic finally made it through. Sigh..


45 posted on 03/02/2006 2:32:50 PM PST by Millee (Don't make me get out my voodoo doll out!)
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To: ShadowDancer

Well, I did make sure I was 20 miles away from you when I posted.


46 posted on 03/02/2006 2:34:04 PM PST by Larry Lucido
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To: anymouse; mad puppy
I guess we'll need a shower after this thread gets going. ;)

Here is a shower mate for you!


47 posted on 03/02/2006 2:34:29 PM PST by SirChas (I seem to be rapidly approaching the apex of my mediocre career)
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To: anymouse

"but the dirty work of evolution is to get rid of bad mutations, and that's where sex seems to play a role."



Now if THAT doesn't get you in the mood...


48 posted on 03/02/2006 2:35:03 PM PST by SE Mom (God Bless those who serve..)
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To: plain talk
Correction. ... might have been designed as a way ...

Certainly the language of the explanation in the article is more appropriate to the actions of a designer than to a set of natural processes.

49 posted on 03/02/2006 2:35:07 PM PST by r9etb
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To: Millee

I thought that was supposed to be a secret, but if not. . . .


50 posted on 03/02/2006 2:36:50 PM PST by Mike Bates (Irish Alzheimer's victim: I only remember the grudges.)
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To: Larry Lucido

I didn't know women could have organisms.


51 posted on 03/02/2006 2:37:02 PM PST by acad1228
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To: Hoodlum91
I think you're short-changing asexual reproduction.

Does it give you hairy palms and make you go blind?
52 posted on 03/02/2006 2:37:17 PM PST by BJClinton (Happy Birthday Texas!)
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To: BJClinton; Lazmataz

Whaa? Up to 52 posts, and nobody's pinged Laz??


53 posted on 03/02/2006 2:40:36 PM PST by Inspectorette
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To: ShadowDancer
...sex isn't just happening between married people

I noticed, but the article said that it concentrates mutation into single individuals.

Since they are a mutation, they should stay single so the rest of the mutations will concentrate in them.

Not my theory, that is what the article says.

54 posted on 03/02/2006 2:40:37 PM PST by Dan(9698)
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To: AntiGuv

I will have none of this filth! (Besides, the thread's already too long gone for deploying the ping list.)


55 posted on 03/02/2006 2:45:49 PM PST by PatrickHenry (Virtual Ignore for trolls, lunatics, dotards, scolds, & incurable ignoramuses.)
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To: anymouse
"The new work could help test a hypothesis first proposed nearly 20 years ago, stating that sex evolved as a way to purge harmful mutations from a population."

Sex didn't evolve; it's designed behavior. It promotes cooperation and self-sacrifice.

Cacti and starfish don't volunteer to sacrifice themselves for the benefit of their clones...but some mates in higher species will.

56 posted on 03/02/2006 2:50:15 PM PST by Southack (Media Bias means that Castro won't be punished for Cuban war crimes against Black Angolans in Africa)
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To: derllak
Check again...Click here
57 posted on 03/02/2006 2:50:54 PM PST by Issaquahking (Either you are with us, or you are with the terrorists.)
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To: anymouse
So... You think I just have all these towel wearing girls at my pad cloned... So I can have my way with them all the time?

Ridiculous... Completely... Ridiculous... Completely... Ridiculous... Completely... Ridiculous... Completely... Ridiculous... Completely... Ridiculous... Completely...

The times change, but The New York Slimes just stays the same...

58 posted on 03/02/2006 2:52:50 PM PST by Bender2 (Redid my FR Homepage just for ya'll... Now, Vote Republican and vote often)
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To: Zuben Elgenubi

What can I say? We love to be clean!

I'm so old I can remember when the air was clean and sex was dirty.


59 posted on 03/02/2006 2:59:39 PM PST by dearolddad
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To: commish
HOw about this hypothesis - Sex has survived for so long because it feels so damn good!!!!
Sex makes me feel better all over than any place else!
60 posted on 03/02/2006 3:03:39 PM PST by dearolddad
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