Posted on 06/02/2009 4:02:00 PM PDT by decimon
In a world-first breakthrough, University of New South Wales (UNSW) medical researchers have used stem cells cultured on a simple contact lens to restore sight to sufferers of blinding corneal disease.
Sight was significantly improved within weeks of the procedure, which is simple, inexpensive and requires a minimal hospital stay.
The research team from UNSW’s School of Medical Sciences harvested stem cells from patients’ own eyes to rehabilitate the damaged cornea. The stem cells were cultured on a common therapeutic contact lens which was then placed onto the damaged cornea for 10 days, during which the cells were able to re-colonise the damaged eye surface.
While the novel procedure was used to rehabilitate damaged corneas, the researchers say it offers hope to people with a range of blinding eye conditions and could have applications in other organs.
A paper detailing the breakthrough appears in the high-impact journal Transplantation this week.
The trial was conducted on three patients; two with extensive corneal damage resulting from multiple surgeries to remove ocular melanomas, and one with the genetic eye condition aniridia. Other causes of cornea damage can include chemical or thermal burns, bacterial infection and chemotherapy.
“The procedure is totally simple and cheap,” said lead author of the study, UNSW’s Dr Nick Di Girolamo. “Unlike other techniques, it requires no foreign human or animal products, only the patient’s own serum, and is completely non-invasive.
“There’s no suturing, there is no major operation: all that’s involved is harvesting a minute amount – less than a millimeter – of tissue from the ocular surface,” Dr Di Girolamo said.
“If you’re going to be treating these sorts of diseases in third world countries all you need is the surgeon and a lab for cell culture. You don’t need any fancy equipment.”
Because the procedure uses the patient’s own stem cells harvested from their eye, it is ideal for sufferers of unilateral eye disease. However, it also works in patients who have had both eyes damaged, Dr Di Girolamo said.
“One of our patients had aniridia, a congenital condition affecting both eyes. In that case, instead of taking the stem cells from the other cornea, we took them from another part of the eye altogether – the conjunctiva – which also harbours stem cells.
“The stem cells were able to change from the conjunctival phenotype to a corneal phenotype after we put them onto the cornea. That’s the beauty of stem cells,” Dr Di Girolamo said.
The therapeutic contact lens used in the trial was of a type commonly used worldwide after ocular surface surgery. However, of the several brands on the market, only one was suitable for growing the stem cells.
“We don’t know why. It’s probably to do with the components the manufacturers have used in that particular lens,” Dr Di Girolamo said.
The researchers are hopeful the technique can be adapted for use in other parts of the eye, such as the retina, and even in other organs. “If we can do this procedure in the eye, I don’t see why it wouldn’t work in other major organs such as the skin, which behaves in a very similar way to the cornea,” Dr Di Girolamo said.
Dr Di Girolamo’s team included UNSW medical scientists Professor Denis Wakefield and Dr Stephanie Watson.
Via nextbigfuture.com
“The research team from UNSW’s School of Medical Sciences harvested stem cells from patients’ own eyes to rehabilitate the damaged cornea.”
These are ADULT stem cells, not the embryonic stem cells that the socialist democrats have been pimping for years SOLELY for their value in pro-death (abortion) politics.
Neverdem,
did you read this?
I’m hoping this can be adapted to the retina (espeically for Macular Degeneration).
Yes. Cheap, simple and possibly adaptable to other eye damage or even other organs. I hope they make progress with this.
Wow!
Thank you.
And what did you think of the article?
Good to know. I have a friend who has AMD.
This stem cell research and the Red Wine extract “reversatol” (sp?) can be a major cost savings boon. By taking care of these problems (diseases) early (in combination of preventative drugs) it would increase the quality of life, limit the ancillary charges of sickness and lower the burden to the insurance/medicare systems.
The challenge is, does our country have the will to do this or will we “nationalize” everything and put everything on hold????
LOL - I was wowing the article. Obviously, this is the dream of stem cell use, immediate "resetting" of a part of the body that is failing, with it's own stem cells (notice no embryonic stam cells were used, but rather those obtained from the defective eyes themselves).
Yes. It seems they use like cells from the patient. I guess that would eliminate rejection problems.
If a the party of a criminal politician is not named, that politician is a Democrat.
If the source of stem cells used in a successful treatment is not specified, they are Adult Stem Cells.
That they are adult stem cells is implicit.
Thanks, bfl
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