Skip to comments.Scripps Research Scientists Reengineer an Antibiotic to Overcome...Antibiotic-Resistant Bacteria
Posted on 08/24/2011 2:36:03 PM PDT by decimon
LA JOLLA, CA August 24, 2011 A team of scientists from The Scripps Research Institute have successfully reengineered an important antibiotic to kill the deadliest antibiotic-resistant bacteria. The compound could one day be used clinically to treat patients with life-threatening and highly resistant bacterial infections.
The results were published in an advanced online issue of the Journal of the American Chemical Society.
[These results] have true clinical significance and chart a path forward for the development of next generation antibiotics for the treatment of the most serious resistant bacterial infections, said Dale L. Boger, who is Richard and Alice Cramer Professor of Chemistry at The Scripps Research Institute and senior author of the new study. The result could not be predicted. It really required the preparation of the molecule and the establishment of its properties.
The compound synthesized is an analogue of the well-known commercial antibiotic vancomycin.
The new analogue was prepared in an elegant total synthesis, a momentous achievement from a synthetic chemistry point of view. In addition to the elegantly designed synthesis, said Jian Xie, postdoctoral fellow in Bogers group and first author on the publication, I am exceedingly gratified that our results could have the potential to be a great service to mankind.
(Excerpt) Read more at scripps.edu ...
micro ping - the presser links the abstract after the title & authors near the end. The abstract includes an image of vancomycin that’s worth a gander, IMHO. Thanks decimon!
In their search for new anti-boitics that kill MSRA, the drugs have serious side effects. I am still fighting the side effects of an antibiotic I took in March.
I hope you recover soon.
Sometimes that antibiotic is all there is to save you. If there are alternate treatments for less serious problems then we should probably be using those.
Still slowly recovering from C-Diff. Vanco saved my life. Thank you for the continued pings!
Glad that you are recovering and you’re welcome.
I got MSRA in the hospital after a surgery. The antibiotics they gave me made me so sick I couldn’t hold food down. I asked them to stop the antibiotics and I beat MSRA on my own.
I wish my side effects would go away.