Research uncovers how fructose in the diet contributes to obesity (Causes intestine to absorb up to 40% more “nutrients,” possibly permanently)

Medical XPress / Weill Cornell Medical College / Nature ^ | Aug. 18, 2021 | Samuel R. Taylor et al

[ConservativeMind]

Eating fructose appears to alter cells in the digestive tract in a way that enables it to take in more nutrients. These changes could help to explain the well-known link between rising fructose consumption around the world and increased rates of obesity and certain cancers.

The research focused on the effect of a high-fructose diet on villi, the thin, hairlike structures that line the inside of the small intestine. Villi expand the surface area of the gut and help the body to absorb nutrients, including dietary fats, from food as it passes through the digestive tract. The study found that mice that were fed diets that included fructose had villi that were 25 percent to 40 percent longer than those of mice that were not fed fructose. Additionally, the increase in villus length was associated with increased nutrient absorption, weight gain and fat accumulation in the animals.

…the team put mice into three groups: a normal low-fat diet, a high-fat diet, and a high-fat diet with added fructose. Not only did the mice in the third group develop longer villi, but they became more obese than the mice receiving the high-fat diet without fructose.

Dr. Goncalves added that humans did not evolve to eat what they eat now. "Fructose is nearly ubiquitous in modern diets, whether it comes from high-fructose corn syrup, table sugar, or from natural foods like fruit," he said. "Fructose itself is not harmful. It's a problem of overconsumption. Our bodies were not designed to eat as much of it as we do."

"There are already drugs in clinical trials for other purposes that target the enzyme responsible for producing fructose-1-phosphate," said Dr. Goncalves. "We're hoping to find a way to repurpose them to shrink the villi, reduce fat absorption, and possibly slow tumor growth."

[ConservativeMind]

Some calories are not equal to others. Eating comparatively more fructose at some point in your life for which your body cannot handle would appear to permanently make your body pull more energy from your food intake.

Yes, you actually can become more fat from the same amount of food. On the positive side, it might be responsible for fewer trips to the toilet.

[I want the USA back]

So fruit is bad. What isn’t? kale and soy?

[aMorePerfectUnion]

There were articles about this at least 10 years ago.

Maybe now some health conscious people will pay attention

[taxcontrol]

I am thinking that it would be an interesting treatment to counter the process described in the article. Perhaps some smart person will figure it out in my lifetime. Till then I am stuck with low carb and fasting.

[Signalman]

Back in the day soda was sweetened with cane sugar. Not HFCS.

[9YearLurker]

But an apple a day...

[NWFree]

What common foods contain the most fructose?

I’m sure I need to be avoiding this as I get older.

[ecomcon]

"There are already drugs in clinical trials for other purposes that target the enzyme responsible for producing fructose-1-phosphate," said Dr. Goncalves. "We're hoping to find a way to repurpose them to shrink the villi, reduce fat absorption, and possibly slow tumor growth."

In nutshell we see the error of modern Pharma. A drug is the cure. They even admit that the problem is eating too much fructose, but they won't tell people to stop consuming fructose; apparently they want people to keep right on with the fructose because they can sell anti fructose treatments.

[circlecity]

“So fruit is bad.”

No, fruit is very good. The corn syrup added to so many foods…..not so much.

[sanjuanbob]

Is wine still ok?

[ConservativeMind]

Actually, half of the sugar molecule is fructose, so just a bit more sugar all the time to excess does this, according to the article.

[Yo-Yo]

What common foods contain the most fructose?

Just about anything that has been sweetened. High-fructose Corn Syrup is much cheaper than cane sugar (sucrose) that it's used in almost all processed foods. Read the ingredient labels.

[BrexitBen]

Woka-Colas are loaded with corn syrup, equal to the equivalent of ten tablespoons of sugar.

[fidelis]

Till then I am stuck with low carb and fasting.

Works for me. I've lost 20 lbs since Christmas that way (so far). I'm short in height for a man so that's a lot for me. I've got about 15 more to go till I'm at about the weight I was when I got married 30 years ago. Of course the last to go is my gut, but it's getting there. My pants are starting to fall off me now.

[PGR88]

So the question needs to be asked, what gave rise to “big corn?”

America grows a lot of corn, and we use it to make expensive car-fuel (ethanol) and we use it to replace sugar, making us fat.

[ConservativeMind]

Strangely, glucose and maltose (two glucose molecules in one) would be sweeteners that would not have fructose, but, unfortunately, the study seems to show that even these would be absorbed up to 40% more, once the aggravating fructose event happens with our intestinal villi.

[Bob434]

If only someone could invent a defructosinator.

[ConservativeMind]

Isn’t low carb a wonderful way to get back to a healthy weight? My wife and I are losing weight with it, too.

[Pikachu_Dad]

‘Retains more nutrients’ is a good thing !

Geez!!!

[Freedom_Is_Not_Free]

And our food supply is flooded with high-fructose corn syrup. High-fructose corn syrup is in EVERYTHING today.

This is intentional. Along with soy lechtin and MSG. They are intentionally creating a toxic food supply. I suspect this is to keep us chronically ill and dependent on drugs and medical treatments. Big Medicine is behind this and has donated to politicians to drench our food supply in high-fructose corn syrup and soy lechtin.

We are really screwed.