N501Y mutation in SARS-CoV-2 Delta variant is key to breakthrough infections

news-medical.net/news/ ^ | Oct 25 2021 | By Jocelyn Solis-Moreira

[BenLurkin]

Several issues arose when comparing SARS-CoV-2 samples from breakthrough infections with the rest of the infected community. For instance, the circulation of viral variants changed over time, with Delta being the predominant strain towards the end of the study period. For this reason, collecting samples of breakthrough infections during the study were uneven and heavily focused on the end of 2021.

To address these concerns, the researchers created a Bayesian analysis combining an autoregressive moving average model with multinominal logistic regression. The model accounted for uncertainty and random changes in viral circulation weekly.

The presence of one Delta lineage, B.1.617.2, resulted in a three-fold increase in breakthrough infections.

A common element in SARS-CoV-2 variants involved in breakthrough infections is the N501Y substitution. The N501Y mutation is observed in Alpha, Beta, and Gamma variants.

Prior research on the N501Y substitution has linked it to increased spike protein binding affinity with the ACE2 receptor and decreased binding of human antibodies to the spike protein.

[algore]

there were 4 corona viruses that infected mankind throughout all of history until 1990.

Since then there have been Sars, Mers, Covid19

Although there is no way this could not be a natural normal occurrence, it is fortunate we had forward looking scientists who studied many ways these viruses might become more deadly and jump to Humans,

Some even considered how to make a profit while mitigating damage should this natural evolution ever happen.

Thank God, and Trust the Science.

[Paladin2]

Right.

And Lesko Fauxcy is an American Hero....

[wannabegeek]

Several issues arose when comparing SARS-CoV-2 samples from breakthrough infections with the rest of the infected community?

Ah, actually no scientist ever even successfully isolated sample of SARS-C0V-2, someone in South Korea claimed they did but it couldn't be replicated to fulfilling or satisfying Koch's postulate.  If they had isolated the virus, they would have been antibody test.

This C0VID thing is all hoax from the gitgo.

Neither is such C0VID-19 asymptomatic transmission.

[noiseman]

Although there is no way this could not be a natural normal occurrence,…

Incredibly foolish assertion. The current coronavirus is most definitely human-engineered, rendering your statement false from the start, not to mention questions about the others.

[A Formerly Proud Canadian]

Ping

[BenLurkin]

Somebody emailed me a meme claiming that. Not sure how it got started when there the technology in use for distinguishing the different strains have been around for a long time.

https://www.cdc.gov/coronavirus/2019-ncov/variants/variant-info.html

https://www.cdc.gov/coronavirus/2019-ncov/variants/cdc-role-surveillance.html

https://www.cdc.gov/coronavirus/2019-ncov/variants/variant-surveillance.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fcoronavirus%2F2019-ncov%2Fcases-updates%2Fvariant-surveillance.html

[Basket_of_Deplorables]

“Some even considered how to make a profit while mitigating damage should this natural evolution ever happen.”

You just know that eventually, it will be discovered that the vaccine companies secretly funded gain of function. Just makes too much sense.

[wannabegeek]

Somebody emailed you, what?

If you have non nonsense brain you'd not believe the bullcrap CDC anymore. She was telling Wolf Blitzer at CNN that there's C0VID-19 asymptomatic transmission, what's up with that. Is there such asymptomatic transmission? Neither aerosol C0VID-19 transmission. You must be paid CDC troll here at FR posting all sorts of BS, and you sold your soul to satan!

[wannabegeek]

Somebody emailed you, what? Correction, I inadvertently pressed "Post" prematurely.

If you have non nonsense brain you'd not believe the bullcrap CDC anymore. CDC acting director Rochelle Walensk was telling Wolf Blitzer at CNN that there's C0VID-19 asymptomatic transmission, what's up with that. Is there such asymptomatic transmission? Neither aerosol C0VID-19 transmission. You must be paid CDC troll here at FR posting all sorts of BS, and you sold your soul to satan!