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Statins may reduce heart disease in people with sleep apnea
Medical Xpress / Columbia Univ Irving Med Center / Annals of the American Thoracic Society ^ | March 13, 2023 | Riddhi Shah et al

Posted on 03/14/2023 8:41:19 PM PDT by ConservativeMind

A study suggests that cholesterol-lowering drugs called statins have the potential to reduce heart disease in people with obstructive sleep apnea, regardless of the use of CPAP machines during the night.

CPAP (continuous positive airway pressure) therapy improves sleep quality in people with obstructive sleep apnea. But CPAP does not improve heart health.

Statins may be one such method, according to the study, by Sanja Jelic, MD.

The researchers found that statins, but not CPAP, protected blood vessels against dangerous inflammatory changes that occur in people with the condition.

The researchers looked specifically at the CD59 protein, which keeps inflammation in check when stabilized in the blood vessels. A previous study by Jelic's team showed that CD59, which protects cells against complement (a group of proteins that promote inflammation) activity, is more stable when cholesterol is low. Among study participants, CD59 was stabilized after four weeks of cholesterol-lowering statin therapy, but not with CPAP alone.

"The effect we found with statins is important," says Jelic. "Inflammation in the blood vessels is a key step in progression of cardiovascular disease, so anything that we can do to stabilize CD59 in these patients is likely to be beneficial."

The researchers also found that CPAP, surprisingly, increases levels of angiopoietin-2, another protein associated with inflammation and heart disease. Elevated angiopoetin-2 is commonly seen in patients on mechanical ventilation but had never been documented among people using CPAP.

"We still believe CPAP is very useful," Jelic says. "But CPAP also seems to have negative effects on the cardiovascular system. We need to investigate whether we should use more conservative airway pressures or other less-utilized treatments like oral appliances to treat patients with obstructive sleep apnea."

Currently, statins are prescribed for only 8% to 13% of patients with obstructive sleep apnea.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: cpap; sleepapnea; statins
CPAP appears to cause some damage that mechanical ventilation does.

Statins reverse one of the subsequent inflammatory markers, CD59, but not the angiopoetin-2.

1 posted on 03/14/2023 8:41:19 PM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 03/14/2023 8:42:09 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

and caúse a million other problems


3 posted on 03/14/2023 8:46:47 PM PDT by TTFX
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To: ConservativeMind
I'm sure the virus jab could be argued to help as well. C'mon, man. /s

Statins are poison.

Obstructive Sleep Apnea and Obesity: Implications for Public Health

Public awareness of the importance of weight loss by lifestyle modification or bariatric surgery to improve the quality of life is needed. These preventive actions, screening measures, and treatment strategies for obesity and OSA can significantly reduce the incidence of obesity, as well as OSA and the related comorbidities such as cardiovascular disease, atherosclerosis, and depression. Finally, health care costs will also be reduced.
Obstructive Sleep Apnea in Cardiovascular Disease: A Review of the Literature and Proposed Multidisciplinary Clinical Management Strategy

Obstructive sleep apnea (OSA) has been associated with many different forms of CVD including hypertension, stroke, HF, coronary artery disease, and atrial fibrillation (AF).1 Adults with OSA not only have an increased risk of developing comorbid CVD but also have worse outcomes related to CVD. OSA is highly prevalent, estimated to affect 34% of men and 17% of women in the general population2 and 40% to 60% of patients with CVD.3 Furthermore, the prevalence is increasing, with these figures representing a 30% increase over the previous 2 decades,2 likely related to the obesity epidemic as well as an aging population."

4 posted on 03/14/2023 9:14:46 PM PDT by logi_cal869 (-cynicus the "concern troll" a/o 10/03/2018 /!i!! &@$%&*(@ -)
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To: ConservativeMind

Best method to minimize heart attacks is regular mild aerobic exercise. No side effects and benefits galore.
1. Reduce heart attacks
2. Reduce joint pain issues
3. Better sleep experience
4. Keeps excess weight down
5. Improve blood pressure
6. Improve H1C blood sugar readings
7. Better sex performance
8. Attract more sex partners with better body
9. Improved lung function
10. Improve kidney function by moving more blood through
11. Delay onset of dementia
12. Very low cost


5 posted on 03/14/2023 9:39:13 PM PDT by entropy12 (Food is most popular anxiety drug, exercise is the least popular.)
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To: ConservativeMind

Apnea and snoring went away for me when I quit sugar and carbs. Losing weight and particularly inflammation does wonders for snoring. Now I require a lot less sleep too.

Sleep quality is one of the big three life improvements I found from going low carb/high fat. The other two the end of acid reflux and blood pressure normalized.

Too bad more people can’t figure out the sugar and carbs are making them miserable and killing them. Of course drug companies couldn’t sell statins if people figured that out.


6 posted on 03/14/2023 9:39:56 PM PDT by Flying Circus
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To: All

The VA is pretty focused on Sleep Apnea because it is more present proportionally in veterans than the general population.

A marker for Sleep Apnea is a build up of red blood cell count. The lessened oxygen during sleep forces the body to create more red blood cells to transport oxygen. This does thicken the blood and predispose for clots.

This study is looking for effects on the vessels themselves rather than on blood.

So CPAP is about more than improving sleep. It’s also reducing red blood cell count.


7 posted on 03/14/2023 10:22:24 PM PDT by Owen
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To: ConservativeMind

Statins kill you dead.


8 posted on 03/15/2023 12:07:53 AM PDT by Revel
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To: ConservativeMind

They are working overtime to justify using statins - which cause more problems than they supposedly “solve”.

My cholesterol levels are perfect, but since I’m over 55, they wanted to put me on statins, “just because” - I told them where to put the statins...


9 posted on 03/15/2023 5:30:16 AM PDT by trebb (So many fools - so little time...)
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To: ConservativeMind

I use the CPAP. It changed my life for the better by enabling me to get more oxygen to my brains while sleeping. I wake up in the morning more refreshed.

Crestor is the brand name for rosuvastatin, and Lipitor is the brand name for atorvastatin. I’ve seen big reliable studies that show the rosuvastatins like crestor reduce all cause mortality risk better than do the atorvastatins like lipitor. I switched from Lipitor to Crestor.

I’m not sure how this study factors that in.


10 posted on 03/15/2023 5:50:45 AM PDT by ckilmer (q)
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To: trebb

No one should do statins, “just because.”

My primary “nurse practitioner” wanted to put me on statins after one cholesterol test showed higher, but I had just started Keto, too, and had told that to the nurse practitioner. I was told about the statins by her nurse, on the phonr.

I told her no doctor has credibility suggesting statins off of just one higher cholesterol test. Maybe off of two, over several months, but not one from a new dietary change. I said that every doctor should know that takes more than one test. She chuckled and said she understood and that she would pass that on to the nurse practitioner.

I never went back to her, but my wife later did, and the nurse practitioner was shocked she showed up, after what I had told the nurse.

Doctors and nurse practitioners mean well, but you have to constantly sanity check what they suggest. This is easier to do, for most people, by an expensive second opinion, but it’s cheaper when you go in knowing more about your likely condition and the wealth of options available.

Do note insurance companies limit some treatment options. I just wish doctors would tell patients why they settled on a bad, old practice, due to your insurance’s directives.


11 posted on 03/15/2023 5:57:16 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ckilmer

I’m wondering if those “reliable studies” were paid for by the drug companies.


12 posted on 03/15/2023 6:17:25 AM PDT by GrannyAnn ( )
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To: ConservativeMind

Yep - my question to the doctor was, “What compelling reason do I have to put that crap in my body if there’s no current issues?” He couldn’t answer, which told me that Big Pharm is paying a lot for them to prescribe crap that isn’t needed.


13 posted on 03/15/2023 8:38:32 AM PDT by trebb (So many fools - so little time...)
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To: GrannyAnn

I’m referring the famous 2011 Jupiter Study.


14 posted on 03/15/2023 3:42:08 PM PDT by ckilmer (q)
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To: trebb

Cholesterol/CVD is the greatest medical fraud in human history.


15 posted on 03/15/2023 9:59:20 PM PDT by logi_cal869 (-cynicus the "concern troll" a/o 10/03/2018 /!i!! &@$%&*(@ -)
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To: ckilmer
I sincerely hope that you survive Crestor: It nearly killed me. I quit it and henceforth fired my doctor, who 'recommended' it while I was still naive. I've taken nothing since.

If you are taking statins for cholesterol, you are victim to the greatest medical fraud ever.

Fwiw, this is my latest lipid panel, tested just out of curiosity:


16 posted on 03/15/2023 10:12:29 PM PDT by logi_cal869 (-cynicus the "concern troll" a/o 10/03/2018 /!i!! &@$%&*(@ -)
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To: ckilmer

And for what it’s worth again, Familial hypercholesterolemia (FH) - characteristic of my family but applies to high cholesterol in general - is only hazardous to health in a state of systemic inflammation...a theory of mine rooted in my book.


17 posted on 03/15/2023 10:16:13 PM PDT by logi_cal869 (-cynicus the "concern troll" a/o 10/03/2018 /!i!! &@$%&*(@ -)
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To: logi_cal869

Yep - and I have yet see where they assert that lowering cholesterol with their drugs has improved/lengthened lives...there’s a good chance it has done exactly the opposite.


18 posted on 03/16/2023 4:56:05 AM PDT by trebb (So many fools - so little time...)
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To: Flying Circus

I also eat low carb and have for a decade or more. My cholesterol is now around 100 and other lipid profile measure are equally good. My A1C dropped from 6.2 to 5.2 and has stayed there. After a decade of success, my doctor still admonishes me for not eating a low cholesterol diet. She can’t explain medically why, only that it is the policy of the Hospital. She quietly admits what I’m doing works and recommends low carb eating, but won’t do it officially.


19 posted on 03/16/2023 5:05:52 AM PDT by IamConservative (I was nervous like the third chimp in line for the Ark after the rain started.)
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