Skip to comments.Human Fat Stem Cells Yield Bone Cells
Posted on 06/28/2004 9:59:00 AM PDT by Wonder Warthog
Pennington Scientists Turn Human Fat Cells Into Bone 5/7/2004
BATON ROUGE - Calling human fat a new and more abundant source of adult stem cells, Pennington Biomedical Research Center scientists have witnessed human fat stem cells convert into bone when slipped under the skin of mice.
Pennington center expert and senior scientist Dr. Jeffrey Gimble, working with Kevin Hicok and Dr. Lyndon Cooper at the University of North Carolina-Chapel Hill and colleagues from Artecel Sciences, found that adult stem cells isolated from human fat can form bone. Their latest findings, published this week in the journal Tissue Engineering, are among the first experiments where human fat stem cells convert to bone once implanted into a live animal. A paper appearing in the same issue of Tissue Engineering from a Danish team led by Dr. Moustapha Kassem reports similar observations.
Stem cells, found in all animals, are unspecialized cells that have the ability to convert to many specific cell types. Researchers had earlier determined that various signals in a growing animal cause stem cells to develop into bone, nerve, muscle, fat and other tissue types. This process was recently duplicated in the lab. At the annual meeting of the Orthopedic Research Society in February, 2004, Gimble and his colleagues at Duke University announced the results of experiments which demonstrated that individual stem cells in human fat, under the right biological environment, could turn into muscle, cartilage, bone or perhaps even nerve cells. Now, researchers have seen the results in a live animal.
"Because human fat is abundant and simple to obtain by liposuction, this finding holds the promise that patients in need of bone grafts could potentially use their own fat as a source of new bone cells," Gimble said. To grow human bone, Gimble and team extracted human fat through liposuction, identified and extracted just the stem cells and multiplied them in the lab. Next, they attached the growing stem cells onto a chip of artificial bone and implanted the chip under the skin of mice for six weeks. When Gimble removed the bone chip, he found the stem cells had converted to living human bone cells and had begun to grow on their own.
"These are exciting, but preliminary, findings", said Gimble. He cautioned that further experiments in animal models will be needed before this science can be used in a clinical setting.
Dang it... I knew I was not fat - just big boned!!!
Good find. And encouraging news. Pro-life bump.
does this mean that michael moore is going to fossilize?
Yes, but he will be coprolite.
This is interesting. It perhaps gives a solid reason to what I've always heard ... fat women have less trouble with their bones than skinny ones.
"Because human fat is abundant ..."
Boy isn't that the truth!
Of course this news will not be a headliner on the media whore circuit since not a single embryo was ripped apart to provide the stem cells! Liberals, so predictable, such a disease; Democrat leadership, such a vector for this insidious disease.
POST OF THE DAY!
Coprockologist - One who studies very bad TV shows.
This could be a record size for coprolite!
Thanks for the ping.
I bet they'll have a lot of people try to sign up as donors in order to get the "free" liposuction!
I wonder how many people Michael Moore can save from bone degeneration?
Sounds like the article left something out here. There doesn't seem to be any reason why the fat cells would "know" to be bone, if they're attached to an artificial bone chip.
Please let me know if you want on or off my Pro-Life Ping List.
It may also imply that the requirements for the "template" are less stringent than thought.
Looks like I'm full of stem cells.
Another reason why we don't have to harvest babies for their body parts.
Adult stem cells work there is NO need to harvest babies for their body parts.
|Alzheimer's gene therapy trial shows early promise||Drug slows advanced Alzheimer's disease
*In 2000, Israeli scientists implanted Melissa Holley's white blood cells into her spinal cord to treat the paraplegia caused when her spinal cord was severed in an auto accident. Melissa, who is 18, has since regained control over her bladder and recovered significant motor function in her limbs - she can now move her legs and toes, although she cannot yet walk.
This is exactly the kind of therapy that embryonic-stem-cell proponents promise - years down the road. Yet Melissa's breakthrough was met with collective yawns in the press with the exception of Canada's The Globe and Mail. Non-embryonic stem cells may be as common as beach sand.
They have been successfully extracted from umbilical cord blood, placentas, fat, cadaver brains, bone marrow, and tissues of the spleen, pancreas, and other organs. Even more astounding, the scientists who cloned Dolly the sheep successfully created cow heart tissue using stem cells from cow skin. And just this week, Singapore scientists announced that they have transformed bone-marrow cells into heart muscle.
Research with these cells also has a distinct moral advantage: It doesn't require the destruction of a human embryo. You don't have to be pro-life to be more comfortable with that.
*In another Parkinson's case, a patient treated with his own brain stem cells appears to have experienced a substantial remission with no adverse side effects. Dennis Turner was expected by this time to require a wheelchair and extensive medication. Instead, he has substantially reduced his medication and rarely reports any noticeable symptoms of his Parkinson's. Human trials in this technique are due to begin soon.
*Bone marrow stem cells, blood stem cells, and immature thigh muscle cells have been used to grow new heart tissue in both animal subjects and human patients. Indeed, while it was once scientific dogma that damaged heart muscle could not regenerate, it now appears that cells taken from a patient's own body may be able to restore cardiac function. Human trials using adult stem cells have commenced in Europe and other nations. (The FDA is requiring American researchers to stick with animal studies for now to test the safety of the adult stem cell approach.)
*Harvard Medical School researchers reversed juvenile onset diabetes (type-1) in mice using "precursor cells" taken from spleens of healthy mice and injecting them into diabetic animals. The cells transformed into pancreatic islet cells. The technique will begin human trials as soon as sufficient funding is made available.
*In the United States and Canada, more than 250 human patients with type-1 diabetes were treated with pancreatic tissue (islet) transplantations taken from human cadavers. Eighty percent of those who completed the treatment protocol have achieved insulin independence for over a year. (Good results have been previously achieved with pancreas transplantation, but the new approach may be much safer than a whole organ transplant.)
*Blindness is one symptom of diabetes. Now, human umbilical cord blood stem cells have been injected into the eyes of mice and led to the growth of new human blood vessels. Researchers hope that the technique will eventually provide an efficacious treatment for diabetes-related blindness. Scientists also are experimenting with using cord blood stem cells to inhibit the growth of blood vessels in cancer, which could potentially lead to a viable treatment.
*Bone marrow stem cells have partially helped regenerate muscle tissue in mice with muscular dystrophy. Much more research is needed before final conclusions can be drawn and human studies commenced. But it now appears that adult stem cells may well provide future treatments for neuromuscular diseases.
*Severed spinal cords in rats were regenerated using gene therapy to prevent the growth of scar tissue that inhibits nerve regeneration. The rats recovered the ability to walk within weeks of receiving the treatments. The next step will be to try the technique with monkeys. If that succeeds, human trials would follow.
*In one case reported from Japan, an advanced pancreatic cancer patient injected with bone marrow stem cells experienced an 80 percent reduction in tumor size.
* In separate experiments, scientists researched the ability of embryonic and adult mouse pancreatic stem cells to regenerate the body's ability to make insulin. Both types of cells boosted insulin production in diabetic mice. The embryonic success made a big splash with prominent coverage in all major media outlets. Yet the same media organs were strangely silent about the research involving adult cells.
Stranger still, the adult-cell experiment was far more successful - it raised insulin levels much more. Indeed, those diabetic mice lived, while the mice treated with embryonic cells all died. Why did the media celebrate the less successful experiment and ignore the more successful one?
* Another barely reported story is that alternative-source stem cells are already healing human illnesses.
*In Los Angeles, the transplantation of stem cells harvested from umbilical-cord blood has saved the lives of three young boys born with defective immune systems.
This [isolating stem cells from fat] could take the air right out of the debate about embryonic stem cells, said Dr. Mark Hedrick of UCLA, the lead author. The newly identified cells have so many different potential applications, he added, that it makes it hard to argue that we should use embryonic cells. -- Thomas H. Maugh II, Fat may be answer to many illnesses, Los Angeles Times, 4/10/01
With the newest evidence that even cells in fat are capable of being transformed into tissue through the alchemy of biotechnology, some scientists said they are beginning to conclude theyll be able to grow with relative ease all sorts of replacement tissues without resorting to embryo or fetal cells Its highly provocative work, and theyre probably right, said Eric Olson, chairman of molecular biology at the University of Texas Southwestern Medical Center in Dallas Like many biologists, Olson believes that adult, fetal and embryonic stem cell research all merit support its heartening, he said, that almost every other week theres another interesting finding of adult stem cells turning into neurons or blood cells or heart muscle cells. Apparently our traditional views need to be reevaluated. --Rick Weiss, Human Fat May Provide Stem Cells, The Washington Post, 4/10/01
In a finding that could offer an entirely new way to treat heart disease within the next few years, scientists working with mice and rats have found that key cells from adult bone marrow can rebuild a damaged heartactually creating new heart muscle and blood vessels Until now researchers thought that stem cells from embryos offer the best hope for rebuilding damaged organs, but this latest research shows that the embryos, which are politically controversial, may not be necessary. We are currently finding that these adult stem cells can function as well, perhaps even better than, embryonic stem cells, [Dr. Donald] Orlic [of the National Human Genome Research Institute] said. --Robert Bazell, Approach may repair heart damage, NBC Nightly News, 3/30/01.
[Dr. Donald] Orlic said fetal and embryonic stem cell researchers have not been able to show the regeneration of heart cells, even in animals. This study alone gives us tremendous hope that adult stem cells can do more than what embryonic stem cells can do, he said. --Kristen Philipkoski, Adult Stem Cells Growing Strong, Wired Magazine, 3/30/01
Like several other recent studies, the new work with hearts suggests that stem cells retrieved from adults have unexpected and perhaps equal flexibility of their own, perhaps precluding the need for the more ethically contentious [embryonic] cells. --Rick Weiss, Studies Raise Hopes of Cardiac Rejuvenation, The Washington Post, 3/31/01
Umbilical cords discarded after birth may offer a vast new source of repair material for fixing brains damaged by strokes and other ills, free of the ethical concerns surrounding the use of fetal tissue, researchers said Sunday. --Umbilical cords could repair brains, Associated Press, 2/20/01.
"PPL Therapeutics, the company that cloned Dolly the sheep, has succeeded in reprogramming' a cell -- a move that could lead to the development of treatments for diseases such as diabetes, Alzheimer's and Parkinson's. The Scotland-based group will today announce that it has turned a cow's skin cell into a beating heart cell and is close to starting research on humans... The PPL announcement...will be seen as an important step towards producing stem cells without using human embryos." --"PPL follows Dolly with cell breakthrough," Financial Times, 2/23/01
Because they have traveled further on a pathway of differentiation than an embryos cells have, such tissue specific [adult] stem cells are believed by many to have more limited potential than E[mbryonic] S[tem] cells or those that PPL hopes to create. Some researchers, however, are beginning to argue that these limitations would actually make tissue-specific stem cells safer than their pluripotent counterparts. University of Pennsylvania bioethicist Glenn McGee is one of the most vocal critics on this point: The emerging truth in the lab is that pluripotent stem cells are hard to reign in. The potential that they would explode into a cancerous mass after a stem cell transplant might turn out to be the Pandoras box of stem cell research. --Erika Jonietz, Biotech: Could new research end the embryo debate? Technology Review, January/February, 2001.
Hey I gots lots of those! Where can I go to donate them? ;o)
I suspect that, perversely, they want to have to depend on unborn babies for the sake of the agenda. I'm willing to be wrong here, but what is the alternative explanation?
Whoooeee! Finally this may be a way for me to get rich! I'll be happy to sell my human fat cells to the scientists - And I've got a million of them!