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Malaria drug links elite soldier suicides
UPI ^ | 9/7/04 | Dan Olmsted, Mark Benjamin

Posted on 09/07/2004 5:20:02 PM PDT by ebersole

By MARK BENJAMIN and DAN OLMSTED WASHINGTON, Sept. 7 (UPI) -- A startling pattern of violence and suicide by America's most elite soldiers has followed their use of a controversial anti-malaria drug, an investigation by United Press International and CNN has found.

The government already warns that the drug, called Lariam, might cause long-term mental problems -- including aggression and suicide.

Six Special Forces soldiers who took their lives are all believed to have taken the drug, according to the UPI-CNN investigation. The cable news network broadcast a segment on the joint investigation Tuesday.

Sen. Dianne Feinstein voiced concern about Lariam and the Special Forces suicides. The California Democrat had previously written key government officials seeking an urgent review of Lariam use.

"I have long been concerned about the use of the drug Lariam for service members and other U.S. government employees deployed abroad," Feinstein told UPI. "Now, there is an indication that Lariam may have contributed to the suicides of some of our nation's elite troops.

"The Department of Defense, and all other government agencies that give this drug to their employees, should immediately reassess their decision to use Lariam and look for alternatives that can protect our troops without causing dangerous side effects."

The Pentagon announced in February that it is investigating whether there is a link between the drug and any soldier suicides. But it defends Lariam, known generically as mefloquine, as both highly effective and safe for soldiers to take. Army medical officials declined requests for an interview but said in a written statement, "We have no data that indicate that Lariam was a factor in any Army suicides in Operation Iraqi Freedom and Operation Enduring Freedom (Afghanistan)."

Instead, the Army said, the deaths were linked to "failed personal relationships, financial crises, legal difficulties and mental problems like depression and psychosis" -- the same factors that trigger suicide in the general public, magnified by ready access to guns.

The psychotic behavior and suicides are particularly jarring because Special Forces soldiers are highly trained and psychologically vetted. An Army study in 2000 showed Special Forces soldiers produce more of a chemical in the brain that helps them cope with and recover from extreme duress.

"It's just antithetical to their whole practice of their craft to suddenly lose control, become depressed, paranoid, hallucinate and become suicidal," said Dr. Paul Ragan, associate professor of psychiatry at Vanderbilt University and a former military psychiatrist. "You have to look for some exogenous factor, some outside factor, something new in the mix that will change how they've otherwise been able to operate."

Those deaths then raise concerns about the tens of thousands of soldiers who have taken Lariam during the war on terrorism -- and about dozens of suicides and a handful of murders among troops while overseas or after returning home.

The pattern also suggests that the Army might have missed the cause of three murder-suicides involving Special Forces soldiers at Fort Bragg, N.C., in the summer of 2002. A report by the Army surgeon general's office blamed marital problems for all the deaths and called Lariam an unlikely factor. But the report did not consider physical or mental problems among the three Special Forces soldiers, described by family and friends, that fit side effects from Lariam.

The UPI/CNN investigation found three more suicides by Special Forces soldiers -- all of them Green Berets believed to have taken Lariam. None appears to have had acute marital problems, combat stress or other personal issues that would help explain their sudden plunge into violence.

- A 43-year-old Special Forces weapons sergeant killed himself in 1997 in Ecuador, where he was helping train Ecuadorian Special Forces. Engaged to be married, he smilingly picked up a gun and shot himself in the head in front of two fellow soldiers.

- A Special Forces sergeant killed himself in July 2003 in the Washington suburb of Alexandria, Va. Happily married and expecting his first child, Tyler Whiffen, 32, went to the woods behind his condominium and shot himself in the head. "He wasn't depressed at all," said Karla Whiffen, his widow and mother of his 6-month-old son. "In fact, I have never known anyone to enjoy life so much. For him to take his life was so out of the blue. Nothing has surfaced that would make this anything but this drug." Whiffen took Lariam in Afghanistan.

- The most recent case involved Special Forces Chief Warrant Officer William Howell, 36, who served in Iraq and killed himself after returning to Fort Carson, Colo. His wife, Laura, also reported no marital problems. He killed himself in March after stalking her around their yard with a gun and pointing it in her face. He shot himself when police arrived.

"I knew my husband, I knew who he was. I know what he was," said Laura Howell. "The only difference was one pill. A little white pill that he took. There was nothing else in his life that was different, in his job, nothing. And there was no accumulative effect of anything in his life that would lead to suicide."

The suicides since Sept. 11, 2001, identified by the UPI-CNN investigation are the only Special Forces suicides during that period, according to the Army. It could provide no data on Special Forces suicides before then or on the number of Special Forces soldiers who have taken the drug.

Lariam has physical and mental side effects. A cluster of physical symptoms also appeared in the pattern of Special Forces soldiers who committed suicide, matching those noted by the Food and Drug Administration, including diarrhea, rash, headaches, trembling and night sweats.

For example, after taking Lariam in Iraq, Bill Howell specifically complained of ringing in the ears, panic attacks, headaches, diarrhea, vomiting, skin rash and tingling and numbness in his hands and feet. All are listed under adverse reactions on Lariam's official product label.

The Department of Veterans Affairs recently alerted every doctor in the VA healthcare system to be on the lookout for soldiers suffering mental or physical problems from taking Lariam, even if the service members had not taken the drug for a long time.

This summer, a Navy doctor at a Pentagon treatment facility in San Diego has begun to diagnose service members with permanent brain-stem damage and fingered Lariam as the apparent culprit. One Special Forces soldier diagnosed with that permanent damage said Lariam has given him homicidal and suicidal urges.

"I can tell you from my own personal experience that it goes from zero to 100 very quickly," said this active-duty soldier, who asked not to be identified for fear of retribution. "You're ready to take that plunge into hurting someone or hurting and killing yourself, and it comes on unbelievably quickly. It's just a sudden thought it's the right thing to do. You'll get a mental picture, and it's in full color."

He said that after taking the drug he attacked his wife and considered suicide for the first time.

The 1997 apparent suicide of a Special Forces soldier uncovered in the UPI-CNN investigation involved a Green Beret weapons sergeant who was in a room with two other soldiers at a base near Quito, Ecuador.

"He had picked up the team sergeant's weapon. He looked at the team sergeant and asked if it was loaded. Then he looked at my other friend, smiled, and pulled the trigger," said Justin Schuman, a former Army staff sergeant who retired in June. Schuman was not in the room during the shooting but was present when the medical helicopter arrived. He said the two soldiers who were in the room at the time immediately described what happened.

"We were at a loss. We really had no idea what possessed him to do that," Schuman said. "We knew there were some stressors in his life. He was about to get remarried, but there was nothing in particular. Nobody mentioned Lariam."

Schuman said he and the two soldiers who were present decided to portray the incident as an accident.

"We told Army investigators that it was an accidental discharge because (we feared) they would have denied his family all his benefits. Because he never said anything about suicide, we just played it off as if he was playing suicide."

But it could not have been an accident, he said. "There really is no more trained person in the world than a trained (Special Forces) weapons sergeant. I can't tell you that it was the Lariam, but he was on Lariam at the time and he committed suicide right in front of us in a very bizarre way."

Last year, the FDA ordered that all patients given Lariam be told in writing about rare reports of suicide, along with psychiatric side effects that have been reported to last "long after" someone stops taking it. The FDA says it does not know if Lariam caused any of the reported suicides.

While malaria can be deadly, there are other drugs that prevent it. A recent study showed that 29 percent of people taking Lariam had some kind of mental problem -- twice the rate of a similar malaria drug.

The violent behavior that accompanied all but one of the Special Forces suicides raises troubling issues because experts say that a drug that could trigger homicide should not be prescribed to anyone. Karla Whiffen said her husband shoved her on two separate occasions -- once knocking her to the ground -- after returning from Afghanistan, something he had never done before.

Laura Howell said her husband punched her "four or five times in the head" before he went to get the gun he ultimately used to kill himself. He had struck her once before, when he was taking steroids to bulk up. "He was very sensitive to chemicals. Anything that had a side effect to it, he would get it," she said.

At Fort Bragg, none of the three Special Forces soldiers involved in the murder-suicides in 2002 had any known history of domestic violence, according to family, friends and police. Experts said it is rare for a domestic homicide not to be preceded by an escalating pattern of violent abuse.

Lariam's manufacturer, Swiss pharmaceutical giant Hoffmann-La Roche, said in a statement by spokesman Terence Hurley that there is "no credible scientific evidence" linking Lariam to suicide, suicidal thinking or violent criminal conduct. The rate of serious mental and neurological side effects is "very low," he said, adding that "data from well-designed studies show Lariam to be safe and well-tolerated."

Hurley added: "The label has advised for many years that Lariam should be used with caution in patients with psychiatric disturbances and has disclosed, clearly, that depression and other neuropsychiatric events have been reported among patients who have used Lariam."

He also noted the Army developed the drug and said, "The Army has its own extensive knowledge base and experience with Lariam. As with all decisions regarding prescription medications, the decision about whether Lariam is appropriate for any individual patient -- whether soldier or civilian -- is a matter for the independent medical judgment of the prescribing physician."

Based on a three-month investigation, UPI reported in May 2002 that mounting evidence suggests Lariam has caused such severe mental problems that in a number of cases it has led to suicide


TOPICS: Foreign Affairs; Government; News/Current Events; US: Colorado; War on Terror
KEYWORDS: army; health; lariam; mentalhealth; military; specialforces
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1 posted on 09/07/2004 5:20:03 PM PDT by ebersole
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To: ebersole; backhoe
You might have something on this, backhoe (You have so much to share ... thank you).

I remember when this was controversial what? two/three years ago.

They didn't listen then, and if I remember correctly, at least one man took a courts-martial rather than the shot. Some even took an early out or retirement.

2 posted on 09/07/2004 5:27:39 PM PDT by knarf (A place where anyone can learn anything ... especially that which promotes clear thinking.)
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To: knarf
Check that ... I'm confusing this with the Anthrax shot.

Same thing only different.

3 posted on 09/07/2004 5:28:34 PM PDT by knarf (A place where anyone can learn anything ... especially that which promotes clear thinking.)
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To: ebersole

Shoulda just sprayed the areas with DDT first and then sent in troops. Wouldn't need the anti-malaria drugs then.

But I guess junk science is more important the human lives.


4 posted on 09/07/2004 5:29:17 PM PDT by flashbunny
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To: ebersole

Took the stuff for a year... ruins the mind..... takes a full 2 years to get it back.


5 posted on 09/07/2004 5:32:39 PM PDT by Porterville (How can the median price of a home in CA be 450,000 dollars? How? Where is the money?)
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To: flashbunny

I am not sure there is a link...

When my husband fought in the 1973 Yom Kippur war, he was sent on the other side of the Suez canal into Egypt and had to take Lariam for 6 weeks...

No effect...

When I consulted in Equatorial Africa I took it for a few weeks...

No effect either...


6 posted on 09/07/2004 5:33:11 PM PDT by Pitiricus
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To: ebersole

Psychotic behavior? Chris Mathews???


7 posted on 09/07/2004 5:37:14 PM PDT by trustandobey
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To: ebersole
I have to say, I have my doubts about this. Thousands of us took Mefloquine (Lariam), once a week, for months on end, and while there were some side effects -- most of the guys had extremely vivid nightmares -- thousands and thousands of SF soldiers never killed anybody (except the enemy, who needs killing).

Also, Mefloquine has also been used throughout the conventional military extensively, every time they are in a malarial zone, which in this war means since the first deployment to Afghanistan. And SF, active and Guard, have been taking it for years -- malaria is endemic in the third world hell holes we go to, and trust me on this, malaria would wrack up a lot more guys and kill a lot more guys than Lariam could, even if it was a hundred times as bad as this writer suggests.

Now, on the other hand, we had a guy in our unit (then A Co. 1/11th SF, USAR) leave the unit and some years later he killed himself. However, when he was in the unit its area of interest was Arctic Europe -- Norway and the northern USSR. SO Malaria was not a concern and no one ever took Lariam in those days. In his case, he wound up losing his job with the State Police because he ran afoul of Massachusetts's politically connected Bulger crime family. He got depressed and wouldn't welcome his old friends again. Finally, one day, he ended it -- a sad business and those criminals Whitey and Billy Bulger are to blame more than Bill is for his death.

But my point is, yes, even elite SF guys do occasionally suffer sufficient life reverses that they kill themselves. Guys even did it in Vietnam. A guy I know did it in Lebanon. And yes, we reported them as accidental deaths because the Army would screw their families out of insurance and benefits.

I wonder if this post is a preemptive strike on Special Forces men by the mainstream media, because SF veterans have been in the forefront of many of the most damaging attacks on Kerry. Either that, or they want to harm SF because it is effectively prosecuting the war on terrorism.

d.o.l.

Criminal Number 18F

8 posted on 09/07/2004 5:44:24 PM PDT by Criminal Number 18F (The Associated Press: 'If you're going to lie, make it a big lie.')
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To: Criminal Number 18F
A guy I know did it in Lebanon.

Er, make that a guy I knew. Among all the typos in my post, that one is painfully glaring.

d.o.l.

Criminal Number 18F

9 posted on 09/07/2004 5:47:16 PM PDT by Criminal Number 18F (The Associated Press: 'If you're going to lie, make it a big lie.')
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To: ebersole
But the psychotropic drugs Eric Harris and Dylan Klebold were taking had absolutely nothing to do with the Columbine massacre.

Pfizer and Merk say so.

And they will sue anybody who says different, and ruin any physician who says different.

10 posted on 09/07/2004 5:49:04 PM PDT by E. Pluribus Unum (Drug prohibition laws help fund terrorism.)
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To: Pitiricus
My wife and I, along with my brother- and sister-in-law, took it for approx. 1 month in 1999 in S. Africa.

None of us had any ill effect, to my knowledge.

11 posted on 09/07/2004 5:54:07 PM PDT by Constitution Day (Burger-Eating War Monkey)
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To: ebersole

So what's the problem with Chloroquin?


12 posted on 09/07/2004 5:54:30 PM PDT by WorkingClassFilth (A basic lesson I have taught children from early childhood - FLUSH THE JOHN!)
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To: WorkingClassFilth
It is supposedly resistant
13 posted on 09/07/2004 5:57:26 PM PDT by ebersole
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To: Criminal Number 18F

None of the 9 SF soldiers had significant life reverses unless coming home is considered life reverses.


14 posted on 09/07/2004 5:58:33 PM PDT by ebersole
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To: ebersole

Thanks. I have been on that stuff many times, mostly in Central America and Asia but never connected to the military. I trust those in charge to know their business.


15 posted on 09/07/2004 5:59:59 PM PDT by WorkingClassFilth (A basic lesson I have taught children from early childhood - FLUSH THE JOHN!)
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To: WorkingClassFilth
There is a new medication out which is as effective and safer. I believe it is called meladrone. You can check Lariam Action USA's website for the medication which is most recommended
16 posted on 09/07/2004 6:01:44 PM PDT by ebersole
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To: WorkingClassFilth

Doesn't work against the new strains of Malaria...

This is why you need mefloquin...


17 posted on 09/07/2004 6:14:00 PM PDT by Pitiricus
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To: Criminal Number 18F

18F I can guarantee you with a 100% that no one in this story is targeting SF, and the writer is about as apolitical as a reporter can get. In fact, he has worked extensively with the Gulf Veterans Center to make sure information is brought forward to the military so that those soldiers (however few they may be) receive the appropriate disability benefits. Those of use who have been around SF for a very long time know how your bodies break down at a fast rate and how notoriously the military does not acknowledge the damage. I agree that there are a significant number of soldiers who have no problems with the drug, and that malaria is a disease no one wants. However, I would hope that SF command would not follow the regular military down a blind path. Iraq and Afghanistan are not resistent areas for chloroquine, there were only a few cases of malaria in these regions according to the CDC. The CDC does not recommend Lariam for any region of the world(resistent or not). There are safer alternatives that are just as effective in preventing malaria. Since I know the SF soldier to be quite intelligent, my hope is that questions are asked and answered by the command.
Wife of former 18a and CW2


18 posted on 09/07/2004 6:20:31 PM PDT by ebersole
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To: ebersole

"...are all believed to have taken the drug..."

UPIs solid research and reporting is C-R-A-P!!!!!!

Get the damned facts before you write it, asswipes!

Dammit, dammit, dammit!


19 posted on 09/07/2004 6:24:30 PM PDT by 7.62 x 51mm ( Veni Vidi Vino Visa "I came, I saw, I drank wine, I shopped")
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To: ebersole
I think when people try to discount any report that this behavior occurring as an attack on the troops, they are being shortsighted.

How many of us have kids who get a warning every time we take them in for a vaccination?
20 posted on 09/07/2004 6:25:01 PM PDT by ican'tbelieveit
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