First Cystic Fibrosis Cord Blood Collection by Cygenics

Cygenics (ASX: CYN) announce the first cystic fibrosis cord blood collection. Clinical history was made at The Mercy Hospital in Werribee on Easter Saturday, when baby Aiden Brundell donated his cord blood in the hope that his precious stem cells could one day rejuvenate sister Mikaela's lungs, which are failing from cystic fibrosis (CF), and save her life.

This first collection of cord blood from the sibling of a child with CF is a major step towards treating the deadly effects of Australia's most common severe genetic condition among children, for which there is no cure.

Aiden's cord blood collection and storage was free of charge, thanks to a generous donation by private cord blood bank, Biocell Pty Ltd and its parent company CyGenics Ltd.

Professor Bob Williamson, spokesperson for Cystic Fibrosis Victoria, said the fantastic generosity of Biocell and CyGenics to Cystic Fibrosis Australia could extend to collecting as many as 36 cord bloods over three years for families with cystic fibrosis in Australia and New Zealand. This represents a commitment valued at more than A$100,000 (approximately US$75,000) over the three years.

Professor Williamson said, "Everyone agrees that the use of cells from cord blood poses no ethical problems. They are adult stem cells, but because they are taken at birth they are far more flexible and grow more easily than most such cells."

He added "Cord blood stem cells represent a real glimmer of hope for cystic fibrosis sufferers, with their potential to physically rebuild lungs previously considered damaged beyond repair."

"The latest research in Australia, Germany and the United States shows that stem cells from cord blood can give cells that are very similar to lung cells. In a mouse model for cystic fibrosis, the cells help to cure the disease. And here in Melbourne, at The Alfred Hospital, it has been shown that when lungs are transplanted into patients, they appear to take up stem cells from the recipient and integrate them into the airways."

Mr Ian Brown, Managing Director of BioCell and Chief Operating Officer of CyGenics said, "This is an exciting initiative for BioCell to be involved in. The therapeutic potential for stem cells, in not only cystic fibrosis applications, are looking very promising."

Professor Williamson concluded, "There are about one million Australians who are healthy carriers of the cystic fibrosis gene. Carriers are completely healthy, but if two carriers have a child, there is a one in four chance that the baby will be affected by cystic fibrosis. Despite a baby being born with CF in Australia every four days, over 90% of parents are unaware they are healthy carriers of the deadly gene."

"Medical researchers, with the support of the Australian Cystic Fibrosis Research Trust, are working tirelessly to find a cure for cystic fibrosis. The collection and storage of cord blood stem cells represents a real investment in hope for cystic fibrosis sufferers like Mikaela Brundell. The research is under way to use these stem cells in the future in an ethical way, to improve the quality and longevity of Mikaela's life."

About Cystic Fibrosis Cystic fibrosis (CF) is Australia's most common life shortening genetic condition. Sadly there is no cure. Many children with CF used to die in early childhood, but recent advances in treatment have extended life expectancy to 30 years and more.

CF primarily affects the lungs and digestive system, and causes a build up of thick sticky mucus in the body resulting in repeated lung infections and poor digestion. To keep healthy, people with CF must receive chest physiotherapy several times a day to keep their lungs free of mucus and consume enzyme tablets with each meal to help them digest their food. Regular antibiotic treatment and periods of hospitalisation are often required.

Approximately 3000 Australians have CF and a further one million others are healthy carriers of the defective cystic fibrosis gene. If two carriers met and have a child there is a one in four chance for each pregnancy that the child will be affected by cystic fibrosis. In Australia, 1 in every 2500 births results in a child with CF.

For further information about CF please visit: www.cfv.org.au or www.cysticfibrosis.org.au

CytoVations (new product development) based in New Jersey, USA. CyGenics is listed on the Australian Stock Exchange, under the symbol CYN. For more information, please visit www.cygenics.com.

CyGenics is a cell therapy company focused on the development and commercialisation of adult stem cell-related products, services, applications and technologies.

From its headquarters in Australia, CyGenics operates four subsidiaries: Singapore-based CordLife (tissue banking services, in particular, cord blood banking) and Cell Sciences (consumable cell culture products), and Cytomatrix (cell therapeutics and technology development) based in Boston, USA, and CytoVations (new product development) based in New Jersey, USA. CyGenics is listed on the Australian Stock Exchange, under the symbol CYN. For more information, please visit www.cygenics.com.

Steven Fang, Group CEO, CyGenics Ltd Ph : +61 (0)400 933 243 Email: steven.fang@cygenics.com Ian Brown, COO, CyGenics Ltd Mob: +61 (0)438 565 212 Email: ian.brown@cygenics.com Media Inquiries Rebecca Piercy, Buchan Consulting Ph: +61 (0)2 9287 2800 Mob: +61 (0)422 916 422 Email: rpiercy@bcg.com.au Ronald Hee, CyGenics Ltd Ph: +65 6238 0808 Mob: +65 9061 9098 Email: ronald.hee@cygenics.com

Thanks, bro: Mikaela Brundell, who has cystic fibrosis, will receive cord blood from her newborn brother Aiden and her mother Julie.
Picture: Jay Town

Will baby Aiden be a miracle?

BABY Aiden Brundell is more than just a brother: he may also be the miracle cure that could one day save his sister Mikaela's life. Mikaela Brundell, 6, was born with cystic fibrosis, an incurable and fatal genetic disorder. Mikaela is constantly in and out of hospital as she fights chest infections and digestive problems. But scientists hope revolutionary stem-cell therapy could one day help patients such as Mikaela beat the disorder. Mikaela's mum, Julie, donated the umbilical-cord blood from baby Aiden, born on April 15, so stem cells could be extracted from it.

Cystic Fibrosis Victoria spokesman Prof Bob Williamson said it was the world's first stem-cell therapy program to treat cystic fibrosis. "Cord-blood stem cells represent a real glimmer of hope for cystic fibrosis sufferers, with their potential to physically rebuild lungs previously considered damaged beyond repair," he said. Prof Williamson and his colleagues at Melbourne University's pathology department and experts at the Alfred hospital, are researching the treatment's safety and efficacy.

He said it would take years for stem-cell therapy to be available to all cystic fibrosis patients. "We certainly hope there is something in time for Mikaela and other patients with cystic fibrosis," Prof Williamson said. Melbourne-based cord-blood bank Biocell paid for the Brundell cord-blood donation and planned to spend more than $100,000 sponsoring another 36 of them for families in Australia and New Zealand. Umbilical cord blood is rich in stem cells, which are usually found in bone marrow.

Since Australian cord-blood banks began collecting donations in 1996, at least 5800 Victorian mums have donated. Stem-cell therapy is used to treat patients with illnesses such as leukemia, cancer and severe immune deficiency. Stem cells can develop into other cells inside the body, mending damaged muscles, broken bones and injured spinal cords. Stem cells can become very similar to lung cells, which can help cystic fibrosis patients. "The latest research in Australia, Germany and the US shows that stem cells from cord blood can give cells that are very similar to lung cells," Prof Williamson explained.

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