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Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins

A molecular test for Alzheimer's disease could lead to better treatment and therapies. We found 18 signaling proteins in blood plasma that can be used to classify blinded samples from Alzheimer's and control subjects with close to 90% accuracy and to identify patients who had mild cognitive impairment that progressed to Alzheimer's disease 2–6 years later. Biological analysis of the 18 proteins points to systemic dysregulation of hematopoiesis, immune responses, apoptosis and neuronal support in presymptomatic Alzheimer's disease.

1 posted on 10/14/2007 1:24:47 PM PDT by neverdem
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To: neverdem

Just an FYI...my Mom died this week. She was diagnosed as having Alzheimer’s, although I believe it requires an autopsy to know for certain.

Anyways, after several years of worsening memory loss and psychotic episodes, we pulled her off her breast cancer medication. At 85, we figured it wouldn’t matter that much if it came back. During the last few months, we saw significant improvement in her memory, reasoning ability and a decrease in freaking out. She seemed a lot happier during the weeks just before her death.

Just something to think about for anyone struggling with a parent & Alzheimers...take a close look at any meds she/he is taking. Talk about each one with a doctor, to include side effects and any negative interactions.


2 posted on 10/14/2007 1:32:38 PM PDT by Mr Rogers (I'm agnostic on evolution, but sit ups are from Hell!)
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To: neverdem

Mom had some type of demetia.

Truly crazy. Absolutely bizarre.
Otherwise she was healthy. - Until she had a massive heart attack right in front of my wife and kids and died.

I couldn’t save her.

She was sitting on a swing with my wife in the back yard of the house that she had lived in most of her life, almost 50 years, watching her grandchildren play out back. - And she did not even know where she was.


3 posted on 10/14/2007 1:34:28 PM PDT by bill1952 (The 10 most important words for change: "If it is to be, it is up to me")
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To: neverdem
Want to avoid Alzheimer's disease? Avoid using aluminum with food products.

The Romans never did figure out the dangers of storing wine in lead containers. We are taking way too long to figure out the connection between aluminum and Alzheimer's.

It is a fact that all Alzheimer's victims have aluminum deposits in their brains. Yet, no one will say straight out that those deposits are the cause. I suspect that is because of strong lobbying by the aluminum industry.

You think asbestos law suits were a catastrophe? Just wait for this to hit the fan.

7 posted on 10/14/2007 2:04:54 PM PDT by Barnacle (Hunter 2008)
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To: El Gato; Ernest_at_the_Beach; Robert A. Cook, PE; lepton; LadyDoc; jb6; tiamat; PGalt; Dianna; ...
Manufacturers Remove Drugs for Infant Cold

Report ranks jobs by rates of depression

FReepmail me if you want on or off my health and science ping list.

18 posted on 10/14/2007 9:03:33 PM PDT by neverdem (Call talk radio. We need a Constitutional Amendment for Congressional term limits. Let's Roll!)
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To: neverdem; AdmSmith; Berosus; Convert from ECUSA; dervish; Ernest_at_the_Beach; Fred Nerks; ...

Unfortunately, the researchers forgot where they left their research data.

Okay, yeah, that was a pretty naughty.


19 posted on 10/14/2007 10:40:48 PM PDT by SunkenCiv (Profile updated Friday, October 5, 2007. https://secure.freerepublic.com/donate/)
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