Cheers!
Ziggy would approve
Posted on 03/16/2008 5:54:39 AM PDT by CarrotAndStick
Why would you want to go to a luncheon sponsored by an organization like Susan G. Komen, which gives money to Planned Parenthood? If you abhor the organization, don’t go through this little charade with the check and don’t accept their food. Stand by your principles and decline the invitation.
http://www.nature.com/nature/journal/v452/n7184/abs/nature06667.html
http://www.nature.com/nature/journal/v452/n7184/abs/nature06734.html
Growth factors stimulate cells to take up excess nutrients and to use them for anabolic processes. The biochemical mechanism by which this is accomplished is not fully understood but it is initiated by phosphorylation of signalling proteins on tyrosine residues. Using a novel proteomic screen for phosphotyrosine-binding proteins, we have made the observation that an enzyme involved in glycolysis, the human M2 (fetal) isoform of pyruvate kinase (PKM2), binds directly and selectively to tyrosine-phosphorylated peptides. We show that binding of phosphotyrosine peptides to PKM2 results in release of the allosteric activator fructose-1,6-bisphosphate, leading to inhibition of PKM2 enzymatic activity. We also provide evidence that this regulation of PKM2 by phosphotyrosine signalling diverts glucose metabolites from energy production to anabolic processes when cells are stimulated by certain growth factors. Collectively, our results indicate that expression of this phosphotyrosine-binding form of pyruvate kinase is critical for rapid growth in cancer cells.
I value my sister in law and enjoy every opportunity to be with her. I’m not going to not go. I certainly wouldn’t go to a Planned Parenthood luncheon or even a March of Dimes luncheon. I wouldn’t go to this one but for these two women. I respect them more than distrust the organization. I’ve read all the websites and that isn’t going to change.
Donate to the American Cancer Society. It is a wonderful group. I am currently undergoing cancer treatment, and ACS has been just wonderful for arranging transportation, support, etc.
I’m glad to know that. My husband and I are self employed. We strongly believe in charitable living and use our skills and our contacts, he with tenants, I will clients, to give time and treasure in our community. We don’t do a lot of the type of giving that shows up on our tax returns. We probably should. I need to get back in to tything but am not too happy with my Church right now.
Close. It's actually near the end of glycolysis. Glycolysis is the metabolic pathway that converts glucose into acetyl CoA, which then enters into the Krebs cycle (now usually called the citric acid or tricarboxylic acid (TCA cycle).
I’m scanning FR today for articles to read and comment on AFTER St.Pat’s... Got to prepare for this eve & tommorow you know...
I’ll have to look more into this research later. For now, my first thoughts are that this may be a very fruitful avenue to attack rapidly growing tumors (lung, brain, etc.) but may not be so useful against slow ones (prostate, ...)
Confront them about their PC BS!
Factors That Do Not Increase Risk of Breast Cancer
Abortion
Although there has been some controversy in the past about the relationship between abortion and breast cancer risk, the current body of evidence now strongly supports no link between the two [253]-a conclusion further confirmed in a recent National Cancer Institute report [254].
While numerous case-control studies have suggested that abortion may moderately increase the risk of breast cancer [255], the nature of these studies makes the accuracy of their results questionable [253]. Case-control studies rely on the reporting of past behavior, and when it comes to a sensitive topic like abortion, this can have a significant impact on the precision of the information gathered. The cases in these studies-the women with breast cancer-may be much more likely to provide complete information about their abortion history than the controls-the women without breast cancer. Such differences in the completeness of reporting can compromise the accuracy of the study results.
Studies called cohort studies, on the other hand, are much more likely to provide accurate results on the topic of abortion because they tend to gather sensitive information before women are diagnosed with breast cancer. And the results from cohort studies looking at this topic clearly show that abortion does not increase the risk of breast cancer [253,256-265].
CORAM, MT. SINAI, PORT JEFFERSON STATION (CMP) FOLLOW-UP INVESTIGATION pdf link from NY State Dept. of Health
(CANCER RISK FACTORS with references starts on page 25.) BREAST “The importance of reproductive factors in affecting breast cancer risk has been known for a long time. Women who have never given birth (or had a full-term pregnancy) are at a higher risk for breast cancer compared to women who have carried a pregnancy to term.”(Page 26)
If you don’t approve of abortion, don’t support the Komen Foundation. They have been involved in abortion in various ways for many years. Not long ago it became widely known (it was known before but the media did not pick it up) that they donate directly to Planned Parenthood. It’s also been questioned whether the type of “research” they support involves fetal tissue from aborted babies.
If you feel awkward because friends are asking you to donate, you could just say that you have other organizations you’re contributing to at this time. Or you could be honest and say you have concerns donating funds that might ultimately be used for abortion.
Difficult situation, I wish you the best.
Thanks for your graphic and the correction. The last biochem course I took was in 1968, so it is a bit hazy, but your posts brought it back.
A study published in January 2007 by researchers at the University of Alberta, testing DCA on in vitro cancer cell lines and a rat model, found that DCA restored mitochondrial function, thus restoring apoptosis, killing cancer cells in vitro, and shrinking the tumors in the rats.
Interesting—I saw the DCA stuff in the discussion you pointed me to. I hope this turns out to be an important foundation issue for neoplastic cells. And thanks for the follow-up.
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