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Antibiotic Alligator: Promising proteins lurk in reptile blood
Science News ^ | Week of April 12, 2008 | Rachel Ehrenberg

Posted on 04/12/2008 3:14:41 PM PDT by neverdem

Researchers hunting for new antibiotics might get some aid from gator blood. Scientists are zeroing in on snippets of proteins found in American alligator blood that kill a wide range of disease-causing microbes and bacteria, including the formidable MRSA or methicillin-resistant Staphylococcus aureus.

Previous experiments have revealed that gator blood extract cripples many human pathogens, including E. coli, the herpes simplex virus and some strains of the yeast Candida albicans. The serum's antimicrobial power probably derives from protein bits called peptides. Widespread among reptiles and amphibians, several such germ-fighting peptides have been isolated from the skin of frogs in recent years.

Many of these critters live in "sort of nasty places" that are polluted, and gators probably eat all kinds of sick animals, comments Paul Klein, a reptile infectious disease specialist at the University of Florida College of Medicine in Gainesville. Fierce battles with prey and other gators can leave gaping flesh wounds—but the animals are fairly hardy. These peptides provide a first line of defense—important in the lower vertebrates, who have a slower antibody response than humans, says Klein.

"It seems Mother Nature has built in a circulating system of antimicrobial factories that protect the animals while they are waiting to develop the cell-mediated response that we would develop quickly," he says.

Fishing around in the reptile's blood, the scientists identified four or five super-active peptides, reports chemistry doctoral student Lancia Darville of Louisiana State University in Baton Rouge. She collaborated with LSU chemist Kermit Murray and with Mark Merchant of McNeese State University in Lake Charles, La., and presented the work in New Orleans April 6 at a meeting of the American Chemical Society...

(Excerpt) Read more at sciencenews.org ...


TOPICS: Culture/Society; News/Current Events
KEYWORDS: antibiotics; health; medicine

BLOOD BATTALION. Alligator blood harbors proteins that show promise for fighting several disease-causing microbes, including methicillin-resistant bacteria.
U.S. Fish & Wildlife Service
1 posted on 04/12/2008 3:14:41 PM PDT by neverdem
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To: Mother Abigail; EBH; vetvetdoug; Smokin' Joe; Global2010; Battle Axe

micro ping


2 posted on 04/12/2008 3:16:22 PM PDT by neverdem (I'm praying for a Divine Intervention.)
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To: neverdem

Well I suppose gators really are good for something.

Go Dawgs!


3 posted on 04/12/2008 3:17:33 PM PDT by Principled (Vaporize the "Divide and Conquer" taxes - Have everyone pay the same marginal rate!. NRST!)
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To: neverdem

Janet Reno’s late mother should have lived to 100, if that were true.


4 posted on 04/12/2008 3:26:55 PM PDT by appleharvey
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To: neverdem

I would think scavenger critters like vultures, opossum, monitor lizards, etc would have innards full of powerful antibiotics


5 posted on 04/12/2008 3:30:07 PM PDT by fso301
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To: neverdem

hummmmmm Alligator farming!


6 posted on 04/12/2008 3:30:18 PM PDT by Ditter
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To: El Gato; Ernest_at_the_Beach; Robert A. Cook, PE; lepton; LadyDoc; jb6; tiamat; PGalt; Dianna; ...
Embryo Research May Never Produce Cures: Head of UK Stem Cell Network

Getting Forgetful? Then Blueberries May Hold The Key

Discovery of the decade? Injection 'could cure Alzheimer's in minutes'

FReepmail me if you want on or off my health and science ping list.

7 posted on 04/12/2008 3:42:46 PM PDT by neverdem (I'm praying for a Divine Intervention.)
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To: Principled
"Well I suppose gators really are good for something."

I tried gator meat once. It was greasy and awful.

8 posted on 04/12/2008 3:44:55 PM PDT by blackbart.223 (I live in Northern Nevada. Reid doesn't represent me.)
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To: neverdem

Google “maganins”.

Unfortunately, I never thought about why a frog speared early in the evening was alive and hopping 48 hours later.


9 posted on 04/12/2008 3:48:10 PM PDT by GladesGuru (In a society predicated upon freedom, it is essential to examine principle)
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To: neverdem

this is a crock


10 posted on 04/12/2008 4:13:29 PM PDT by gusopol3
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To: Principled
Well I suppose gators really are good for something.

tastiest tail shakin! Well, in the reptile world, that is.

11 posted on 04/12/2008 4:15:17 PM PDT by the invisib1e hand ( If you can keep your head when all about you are losing theirs and blaming it on you...)
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To: blackbart.223
I tried gator meat once. It was greasy and awful.

Sure, that's the alligators fault. ;)

Seriously, bad cut, poorly cooked.

Done right, like about 1.5" filets of tail, breaded and deep fried, and you'll never go back to cheese fingers. If you can afford it.

12 posted on 04/12/2008 4:17:02 PM PDT by the invisib1e hand ( If you can keep your head when all about you are losing theirs and blaming it on you...)
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To: GladesGuru

I was impressed with the resilience of abalone. We would pop them off the undersides of rocks in 60 feet of water, leave them in canvas bags on the deck of the boat all day, throw them on ice in coolers, pull them out of the coolers hours later, then watch in amazement as they attempted to crawl away on the counter top.


13 posted on 04/12/2008 4:18:17 PM PDT by Jeff Chandler (It takes a father to raise a child.)
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To: GladesGuru
Yahoo wanted to offer me magazine. I wondered if your spelling was off.

An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides

SEE RESULTS AND DISCUSSION section. Thank you.

14 posted on 04/12/2008 4:21:23 PM PDT by neverdem (I'm praying for a Divine Intervention.)
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I take a drug called ‘Byetta,’ which was developed from the saliva of the gila monster. It’s used for Type 2 diabetes. Everybody joked for awhile about taking ‘lizard spit,’ but it seems to work very well - at almost $200 a vial, it ought to.

“Exenatide (marketed as Byetta) is the first of a new class of medications (incretin mimetics) approved for the treatment of type 2 diabetes. ... Exenatide is a synthetic version of exendin-4, a hormone in the saliva of the Gila monster, a lizard native to several Southwestern American states. ... Typical human responses to exenatide include improvements in the initial rapid release of endogenous insulin, suppression of pancreatic glucagon release, delayed gastric emptying, and reduced appetite - all of which function to lower blood glucose.”
http://en.wikipedia.org/wiki/Exenatide


15 posted on 04/12/2008 4:37:09 PM PDT by radiohead (I stood up for Fred at the Iowa Caucus. Where were the rest of you so-called conservatives?)
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To: radiohead

There is always these guys:

Komodo dragons also possess virulent bacteria in their saliva, of which more than 28 Gram-negative and 29 Gram-positive strains have been isolated.[21] These bacteria cause septicemia in their victim; if an initial bite does not kill the prey animal and it escapes, it will commonly succumb within a week to the resulting infection. The deadliest bacteria in Komodo dragon saliva appears to be a very deadly strain of Pasteurella multocida, from studies performed with lab mice.[22] Because the Komodo dragon appears immune to its own microbes, much research has been done searching for the antibacterial molecule in the hopes of human medicinal use.[23]

http://en.wikipedia.org/wiki/Komodo_dragon


16 posted on 04/12/2008 4:52:46 PM PDT by Aria (NO RAPIST ENABLER FOR PRESIDENT!!!)
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To: gusopol3
...this is a crock...

yes, it is...as opposed to a Alligator...still looks better, than your typical 'rat voter and/or $hrillary


17 posted on 04/12/2008 4:56:08 PM PDT by skinkinthegrass (just b/c you're paranoid,doesn't mean "they" aren't out to get you..our hopes were dashed by CINOs :)
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To: radiohead

how many doses per vial


18 posted on 04/12/2008 5:01:30 PM PDT by gusopol3
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To: gusopol3

It comes in a pen (does anyone use vials anymore?) You get about a month’s worth - I think you’re supposed to toss it at 28 days, but I try to use it up, 28 days or not. You take 2 doses a day, at breakfast and dinner; the doses are pre-measured. Pretty easy.

It really suppresses the appetite. I notice that it is often 2-3 pm before I am ready to eat again after breakfast.


19 posted on 04/12/2008 5:41:38 PM PDT by radiohead (I stood up for Fred at the Iowa Caucus. Where were the rest of you so-called conservatives?)
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To: gusopol3

I guess I should say that I have pretty good insurance and don’t pay anywhere near the $200.


20 posted on 04/12/2008 5:42:57 PM PDT by radiohead (I stood up for Fred at the Iowa Caucus. Where were the rest of you so-called conservatives?)
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To: neverdem

They should come to Miami and go down the road to pick up a few gators or else just sit around one of our many canals and wait for another 12 footer to show up.


21 posted on 04/12/2008 6:56:07 PM PDT by FreeManWhoCan (An American in Miami)
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To: neverdem

herp med bump


22 posted on 04/12/2008 7:19:28 PM PDT by Luigi Vasellini (What do you call 2 toddlers and some duct tape??........muslim body armor!!!!!!!)
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To: neverdem

I use google in preference to yahoo for just the reasons you describe.

The word “maganin” was found by google. The word is derived from the Hebrew word for shield.

Given that we are now acessing data which once required hours in a library, walking the stacks, I tend to be quite amazed that the Internet works as well as it does.

Google it, Yahoo it, even Dogpile it!

;-)


23 posted on 04/13/2008 7:03:06 AM PDT by GladesGuru (In a society predicated upon freedom, it is essential to examine principle)
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