Posted on 12/04/2008 10:48:50 PM PST by neverdem
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Ping.
When South Africa gets enough colera cases of their own, maybe they will be compelled to actually do something about their bad neighbor to the north.
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Just wondering how long before our government decides to start importing people with cholera. IIRC, being inflicted with some contagious disease have been removed as criteria for admitting immigrants.
Poor Africa. Epic fail, now and forever.
Yup...the more damaging to the USA, the faster they are admitted.
Blame congress.
Interesting. Is there a reason?
O’bama?
There were 1,500 cases of Malaria in the US last year, expect this to quadruple now that it’s in Florida every year from now until West Nile looks like catching the common cold, we’re in for some real misery ....
Type O is the universal donor blood type. It is the most common in the US, with AB being the rarest.
Susceptability is ranked type 0 > type B > type A > type AB. Type AB is virtually immune to cholera.
Cholera produces a toxin that disables GTPase. The consequence is that GTP is not hydrolyzed to GDP, thus signaling a continued production of cyclic-AMP. That causes the colon wall permeability to increase. Fluids rush into the colon and diarrhea ensues.
Death can occur in as little as 3 hours after initial exposure to approximately 1 million organisms. A drop of water could harbor that many.
The literature doesn't seem to have any good explanation for the range of susceptibility. My best guess is that type O cells lack both the type A and type B antigens on the surface of the cells (all cells in the body, not just the blood). I suspect those antigens have an inhibitory effect on the conversion of cholera from the motile (swimming) form to the colonizing form that creates the enterotoxin. There is definitely a physiological change in the cholera organisms after they enter the intestinal tract.
An interesting aside: areas where cholera has been endemic for centuries have fewer type O and lots of type AB inhabitants. Selective pressure.
The white regeime which ran the former Rhodesia was nothing to be proud of, but no one can claim that things are better now. Nothing like this ever happened during those years.
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