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Bacterial Product Isolated in Soil from Easter Island Rescues Learning, Memory in Alzheimer's...
ScienceDaily ^ | Mar. 8, 2010 | NA

Posted on 04/02/2010 1:18:10 PM PDT by neverdem

Bacterial Product Isolated in Soil from Easter Island Rescues Learning, Memory in Alzheimer's Mouse Model

Rapamycin, a drug that keeps the immune system from attacking transplanted organs, may have another exciting use: fighting Alzheimer's disease. The drug -- a bacterial product first isolated in soil from Easter Island -- rescued learning and memory deficits in a mouse model of Alzheimer's, a team from The University of Texas Health Science Center at San Antonio reported on Feb. 23.

The study, in the Journal of Biological Chemistry, offers the first evidence that the drug is able to reverse Alzheimer's-like deficits in an animal model, said the senior author, Salvatore Oddo, Ph.D., assistant professor in the Department of Physiology of the UT Health Science Center San Antonio.

Tissue evidence

Rapamycin also reduced lesions in the brains of the mice, the team found. The lesions are similar to those seen in the brains of people who died with Alzheimer's.

"Our findings may have a profound clinical implication," said Dr. Oddo, who is a member of the university's Barshop Institute for Longevity and Aging Studies. "Because rapamycin is a U.S. Food and Drug Administration-approved drug, a clinical trial using it as an anti-Alzheimer's disease therapy could be started fairly quickly."

Last year three institutions, including the Barshop Institute, announced that rapamycin extended the life span of aged research mice at each of the sites. It was the first pharmacologic intervention shown to extend life in an animal model of aging...

(Excerpt) Read more at sciencedaily.com ...


TOPICS: Culture/Society; News/Current Events; Testing
KEYWORDS: alzheimer; alzheimers; alzheimersdisease; rapamycin
It's starting to look like Alzheimer’s is another autoimmune disease. The press release at ScienceDaily links the abstract. Here a PDF link to the actual article.

MOLECULAR INTERPLAY BETWEEN MTOR, Aβ AND TAU: EFFECTS ON COGNITIVE IMPAIRMENTS MTOR means the mammalian target of rapamycin.

Infection Defense May Spur Alzheimer’s

1 posted on 04/02/2010 1:18:11 PM PDT by neverdem
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To: neverdem

I may be too late for me.............


2 posted on 04/02/2010 1:20:01 PM PDT by Red Badger (Education makes people easy to lead, difficult to drive; easy to govern, but impossible to enslave.)
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To: neverdem

It...........


3 posted on 04/02/2010 1:20:19 PM PDT by Red Badger (Education makes people easy to lead, difficult to drive; easy to govern, but impossible to enslave.)
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To: neverdem

I don’t know if that is the right term for it.

An autoimmune disorder leaves the body attacking itself, even if it might have been set that way by a foreign invader. In this case, if an antibiotic rids the plaques, it’s not killing an invader, but the result of our response to it.

It would seem that the plaques are not our bodies attacking our brains. However, the antibiotic may work via a method that has nothing to do with bacterial death.


4 posted on 04/02/2010 1:22:35 PM PDT by ConservativeMind (Hypocrisy: "Animal rightists" who eat meat & pen up pets while accusing hog farmers of cruelty.)
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To: Red Badger

No, you had that right to begin with if you have Alzheimer’s.


5 posted on 04/02/2010 1:23:10 PM PDT by ConservativeMind (Hypocrisy: "Animal rightists" who eat meat & pen up pets while accusing hog farmers of cruelty.)
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To: ConservativeMind

Had what right?...........


6 posted on 04/02/2010 1:36:47 PM PDT by Red Badger (Education makes people easy to lead, difficult to drive; easy to govern, but impossible to enslave.)
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To: Pride in the USA
Very interesting

Photobucket

7 posted on 04/02/2010 1:43:40 PM PDT by lonevoice (If Fox News is the only outlet reporting it, did it really happen?)
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To: Mother Abigail; EBH; vetvetdoug; Smokin' Joe; Global2010; Battle Axe; null and void; ...
Micro ping

A drug that extends life span prevents Alzheimer's deficits (rapamycin)

I couldn't find the original article at the Public Library of Science. The immunosuppressant rapamycin appears designed to fool the beta amyloid, aka abeta and amyloid beta, of the innate immune system.

Infection Defense May Spur Alzheimer’s

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

8 posted on 04/02/2010 1:59:56 PM PDT by neverdem (Xin loi minh oi)
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To: Red Badger

Y ou had it right the first time.


9 posted on 04/02/2010 2:10:16 PM PDT by tet68 ( " We would not die in that man's company, that fears his fellowship to die with us...." Henry V.)
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To: neverdem

This looks like a big advance, no?


10 posted on 04/02/2010 2:32:31 PM PDT by decimon
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To: lonevoice

This is very interesting indeed. Let’s hope that this bacterial product really does help people who are suffering from Alzheimer’s disease.


11 posted on 04/02/2010 2:33:16 PM PDT by Pride in the USA
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To: decimon
This looks like a big advance, no?

Maybe, but taking immunosuppressants can have adverse effects, usually infections.

12 posted on 04/02/2010 2:39:20 PM PDT by neverdem (Xin loi minh oi)
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To: neverdem
Maybe, but taking immunosuppressants can have adverse effects, usually infections.

Thanks.

What these articles don't go into is dosage and length of treatment when used against alzheimer's.

13 posted on 04/02/2010 2:44:01 PM PDT by decimon
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To: neverdem

Good stuff!


14 posted on 04/02/2010 2:47:06 PM PDT by ConservativeMind (Hypocrisy: "Animal rightists" who eat meat & pen up pets while accusing hog farmers of cruelty.)
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To: 2ndreconmarine; Fitzcarraldo; Covenantor; Mother Abigail; EBH; Dog Gone; ...

Ping...(Thanks, neverdem!)


15 posted on 04/02/2010 3:36:18 PM PDT by Smokin' Joe (How often God must weep at humans' folly. Stand fast. God knows what He is doing.)
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To: Red Badger

What was that again?


16 posted on 04/02/2010 4:03:17 PM PDT by wizr (Keep the Faith! Even when it gets tough! Nothing else will do.)
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To: neverdem

Excellent! I really need some of that memory stuff...


17 posted on 04/02/2010 4:25:18 PM PDT by Nuc1 (NUC1 Sub pusher SSN 668 (Liberals Aren't Patriots))
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To: neverdem
It's starting to look like Alzheimer’s is another autoimmune disease.

Could be good news in the long run...

18 posted on 04/02/2010 5:16:25 PM PDT by GOPJ (Garde la Foi, mes amis! Nous nous sommes les sauveurs de la République! Maintenant et Toujours!)
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To: neverdem
Maybe, but taking immunosuppressants can have adverse effects, usually infections.

I'd bet you could suspend rapamycin long enough to clobber any infection and still derived an excellent therapeutic effect against slow-as-snail-shell-growth Alzheimers.

19 posted on 04/02/2010 5:29:30 PM PDT by null and void (We are now in day 435 of our national holiday from reality. - 0bama really isn't one of US.)
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To: neverdem

This is fascinating stuff- thanks for posting.


20 posted on 04/02/2010 5:31:54 PM PDT by SE Mom (Proud mom of an Iraq war combat vet)
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To: Red Badger

Funny,very funny,but the disease is awful.

They don’t call it “The long goodbye” for nothing.


21 posted on 04/02/2010 6:24:21 PM PDT by Mears
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To: lonevoice

Well, the logical extension of this finding is that we ought to find a cure for breast cancer near an ancient statue of breasts.


22 posted on 04/02/2010 8:37:09 PM PDT by DannyTN
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To: null and void

Or come up with a combined molecule which would double as an antibiotic.


23 posted on 04/02/2010 8:39:56 PM PDT by HiTech RedNeck (I am in America but not of America (per bible: am in the world but not of it))
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To: HiTech RedNeck

Or that...


24 posted on 04/02/2010 8:57:28 PM PDT by null and void (We are now in day 435 of our national holiday from reality. - 0bama really isn't one of US.)
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To: DannyTN

Swamps cause fevers.
God put the cure to a disease near the cause.
Willows grow in swampy areas.
Willow bark treats fevers.

(I’d go further, and venture that the cure for breast cancer could be found near The Grand Tetons)...


25 posted on 04/02/2010 9:03:07 PM PDT by null and void (We are now in day 435 of our national holiday from reality. - 0bama really isn't one of US.)
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To: Smokin' Joe

Thanks for the ping!


26 posted on 04/02/2010 10:06:27 PM PDT by Alamo-Girl
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To: neverdem

There is a safe, inexpensive treatment for Alzheimer’s that should be getting major attention but since there is no money involved it gets ignored.

It’s niacinamide, a B-vitamin. It needs human trials to confirm but it looks very promising. It was given to mice who are bred to have alzheimer’s and in 4 months they were almost back to normal.

Talk about expensive healthcare, one of the reasons it’s so expensive is that there is no incentive to find solutions outside of medications and surgery for everything.


27 posted on 04/03/2010 5:53:05 AM PDT by webstersII
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To: neverdem

Bump.


28 posted on 04/05/2010 5:00:20 AM PDT by nw_arizona_granny ( garden/survival/cooking/storage- http://www.freerepublic.com/focus/chat/2299939/posts?page=5555)
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To: Smokin' Joe

Bump.


29 posted on 04/05/2010 5:00:28 AM PDT by nw_arizona_granny ( garden/survival/cooking/storage- http://www.freerepublic.com/focus/chat/2299939/posts?page=5555)
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To: neverdem
These discoveries always amaze me. I can just hear the conversation in the lab:

"Hey Stewart, lets go to Easter Island and gather up some bacteria and see what we can do with it......"

30 posted on 04/05/2010 5:07:32 AM PDT by Hot Tabasco
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To: Mears

It runs in my family, and I have seen the effects take a vibrant intelligent person and turn them into a total stranger.....................


31 posted on 04/05/2010 5:18:41 AM PDT by Red Badger (Education makes people easy to lead, difficult to drive; easy to govern, but impossible to enslave.)
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To: Bellflower

ping


32 posted on 06/11/2010 2:32:57 PM PDT by Bittersweetmd
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