Posted on 06/09/2012 12:43:55 AM PDT by neverdem
A study led by Karolinska Institutet in Sweden reports for the first time the positive effects of an active vaccine against Alzheimer's disease. The new vaccine, CAD106, can prove a breakthrough in the search for a cure for this seriously debilitating dementia disease. The study is published in the scientific journal Lancet Neurology.
Alzheimer's disease is a complex neurological dementia disease that is the cause of much human suffering and a great cost to society. According to the World Health Organisation, dementia is the fastest growing global health epidemic of our age. The prevailing hypothesis about its cause involves APP (amyloid precursor protein), a protein that resides in the outer membrane of nerve cells and that, instead of being broken down, form a harmful substance called beta-amyloid, which accumulates as plaques and kills brain cells.
There is currently no cure for Alzheimer's disease, and the medicines in use can only mitigate the symptoms. In the hunt for a cure, scientists are following several avenues of attack, of which vaccination is currently the most popular. The first human vaccination study, which was done almost a decade ago, revealed too many adverse reactions and was discontinued. The vaccine used in that study activated certain white blood cells (T cells), which started to attack the body's own brain tissue.
(Excerpt) Read more at sciencedaily.com ...
It has a cause, we just don’t know what it is. Sure seems to be a lot more common these days then 30 years ago.
I get muscle aches from every statin on the market.
After trying all of them, my doctor put me on 2 grams of niacin every day, lo and behold, it works.
That was a very moving post. I won’t get into it, but I went through something over the past year along the same lines. At the end, though, God gave my family a gift...one last visit just like you had in your dream about your grandfather. Hold on to that dream, and revisit your earlier, happy memories of your grandfather often. They are more valuable than any treasures this world has to offer.
It is so hard to understand unless you have experienced it. Even my brother would get angry because “She knows better than that.” but she didn’t.
It is hard to understand and even hard to believe unless you’ve been there.
I remember over 30 years ago finding a woman who was lost and wandering on a freezing Christmas day that wasn’t dressed for. She seemed so sweet and we wondered how the family could have let that happen. Many years later I figured it out because my mother would run away too.
How about animal lard? I love it, but my wife banned it from the house.
High fat diets and sedentary lifestyles are becoming major concerns for Western countries. They have led to a growing incidence of obesity, dyslipidemia, high blood pressure, and a condition known as the insulin-resistance syndrome or metabolic syndrome. These health conditions are well known to develop along with, or be precursors to atherosclerosis, cardiovascular disease, and diabetes. Recent studies have found that most of these disorders can also be linked to an increased risk of Alzheimer's disease (AD). To complicate matters, possession of one or more apolipoprotein E 4 (APOE 4) alleles further increases the risk or severity of many of these conditions, including AD. ApoE has roles in cholesterol metabolism and A clearance, both of which are thought to be significant in AD pathogenesis. The apparent inadequacies of ApoE 4 in these roles may explain the increased risk of AD in subjects carrying one or more APOE 4 alleles. This review describes some of the physiological and biochemical changes that the above conditions cause, and how they are related to the risk of AD. A diversity of topics is covered, including cholesterol metabolism, glucose regulation, diabetes, insulin, ApoE function, amyloid precursor protein metabolism, and in particular their relevance to AD. It can be seen that abnormal lipid, cholesterol and glucose metabolism are consistently indicated as central in the pathophysiology, and possibly the pathogenesis of AD. As diagnosis of mild cognitive impairment and early AD are becoming more reliable, and as evidence is accumulating that health conditions such as diabetes, obesity, and coronary artery disease are risk factors for AD, appropriate changes to diets and lifestyles will likely reduce AD risk, and also improve the prognosis for people already suffering from such conditions.That's the abstract, but it's a FReebie.
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