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Posted on 08/21/2012 11:10:29 AM PDT by Maelstorm
Pregnancy loss is a common and painful condition for gestational women, accounting for 25-40% of total pregnancy, having become a serious social-medical issue worldwide. Animal studies and clinical investigations have indicated that the cause of many mid-term miscarriage/abnormal pregnancy has been seeded very early during the onset of embryo implantation. Epidemiological study also showed that maternal stress at early pregnancy is strongly associated with various complications during ongoing gestation. However, whether and how the process of embryo implantation is affected by environmental factors such as stress induced sympathetic activation remained elusive. Considering the mammalian uterus is an organ with extensive sympathetic innervations, the research group leads by Prof. Enkui Duan at Institute of Zoology, Chinese Academy of Sciences hypothesized that it is possible that around the time of embryo implantation, stress-induced sympathetic activation may directly affect embryo-maternal interactions through adrenergic receptors, therefore affecting the quality of ongoing pregnancy.
By using mouse model, the research group found an unexpected, transient effect of β2-Adrenoceptor (β2-AR) activation (Day4 postcoitus) in disrupting embryo spacing at implantation (without changing implantation timing), leading to substantially increased mid-term pregnancy loss. In vitro and in vivo studies demonstrated that the transient β2-AR activation abolished normal preimplantation uterine contractility, without adversely affecting blastocyst quality. The contractility inhibition is mediated by activation of cAMP-PKA pathway and accompanied with specific downregulation of lpa3, a gene previously found to be critical for uterine contraction and embryo spacing. These results recapitulated the concept that “on-site” intrauterine embryo location mediated by concerted uterine contraction is crucial for successful ongoing pregnancy.
(Excerpt) Read more at rpb.ioz.ac.cn ...
The thread you linked to was pulled by the mods. Said to be “BS”.
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