HIV Vector Licks Leukemia

"Ultimately, the modified T-cell treatment eradicated large amounts of tumors in these patients, as well as normal B cells used by the body's immune system to fight infection. Patients were given regular gamma globulin treatments as a preventive measure."

Ohhhh kay.

If the immune system is wiped out by the modified T-cells, doesn't that leave the patient with an acquired immunodeficiency?

Only part of the adaptive immune system was attacked. Those B lymphocytes confer humoral immunity by making antibodies to foreign pathogens.

Log or Exponential Phase
In this phase, the antibody concentration increases exponentially as the B cells that were stimulated by the antigen differentiate into plasma cells which secrete antibody.

They still have cell mediated immunity courtesy of T lymphocytes and the primitive innate immune system. They directed the attack to leukemic cells expressing CD19. CD stands for cluster of differentiation.

Unfortunately, CD19 is also expressed on B cells, also known as B lymphocytes.

How is that addressed over the long term?

"Patients were given regular gamma globulin treatments as a preventive measure."

That's a "protein fraction of blood serum containing many antibodies that protect against bacterial and viral infectious diseases." It's periodical. I don't know how frequently. It's not cheap. It comes from donated blood. It must be screened for microbes, etc.

Besides being impressive immunologically, somebody did some impressive molecular genetics on HIV to get a knock out version of HIV. They got one or more serious genetic deletions, or the equivalent, how I don't know, in this "disabled" HIV, or these docs are guilty of assault and battery plus attempted murder!

Any corrections are always appreciated. Just don't tell me HIV isn't a lethal pathogen. Koch's postulates have been fulfilled.

"Ultimately, the modified T-cell treatment eradicated large amounts of tumors in these patients, as well as normal B cells used by the body's immune system to fight infection. Patients were given regular gamma globulin treatments as a preventive measure."

Ohhhh kay.

If the immune system is wiped out by the modified T-cells, doesn't that leave the patient with an acquired immunodeficiency?

Only part of the adaptive immune system was attacked. Those B lymphocytes confer humoral immunity by making antibodies to foreign pathogens.

Log or Exponential Phase
In this phase, the antibody concentration increases exponentially as the B cells that were stimulated by the antigen differentiate into plasma cells which secrete antibody.

They still have cell mediated immunity courtesy of T lymphocytes and the primitive innate immune system. They directed the attack to leukemic cells expressing CD19. CD stands for cluster of differentiation.

Unfortunately, CD19 is also expressed on B cells, also known as B lymphocytes.

How is that addressed over the long term?

"Patients were given regular gamma globulin treatments as a preventive measure."

That's a "protein fraction of blood serum containing many antibodies that protect against bacterial and viral infectious diseases." It's periodical. I don't know how frequently. It's not cheap. It comes from donated blood. It must be screened for microbes, etc.

Besides being impressive immunologically, somebody did some impressive molecular genetics on HIV to get a knock out version of HIV. They got one or more serious genetic deletions, or the equivalent, how I don't know, in this "disabled" HIV, or these docs are guilty of assault and battery plus attempted murder!

Any corrections are always appreciated. Just don't tell me HIV isn't a lethal pathogen. Koch's postulates have been fulfilled.

Thanks for the ping!

I pray this successfully gets out of clinical trials.

You’re Welcome, Alamo-Girl!

Cost-effectiveness of splenectomy versus intravenous gamma globulin in treatment of chronic immune thrombocytopenic purpura in childhood

Each additional life saved by employing the IVGG strategy cost $540,000, or $8,000 per year for a life expectancy of 70 years.

Those numbers are over 24 years old. IVGG means intravenous gamma globulin.

I tried calling a local hospital. I got nowhere fast. My BIL is a pharmacist. I left a message. Maybe he can find out more current numbers.