Posted on 03/14/2013 9:26:32 PM PDT by neverdem
Aspirin-related drugs suggest a way towards more effective stem-cell transplants.
Aspirin-like drugs could improve the success of stem-cell transplants for patients with blood or bone-marrow disorders, a study suggests. The compounds coax stem cells from bone marrow into the bloodstream where they can be harvested for use in transplantation — and they do so with fewer side effects than drugs now in use.
For patients with blood disorders such as leukaemia, multiple myeloma or non-Hodgkin’s lymphoma, transplantation of haematopoietic stem cells — precursor cells that reside in the bone marrow and give rise to all types of blood cell — can be an effective treatment.
Previous work has shown that prostaglandin E2, or PGE2, a lipid known to regulate multiple bodily reactions including pain, fever and inflammation, also has a role in keeping stem cells in the bone marrow1, 2. In the latest study, researchers show that in mice, humans and baboons, inhibition of PGE2 with non-steroidal anti-inflammatory drugs (NSAIDs) causes stem cells to leave the bone marrow.
Aspirin-like drugs could improve the success of stem-cell transplants for patients with blood or bone-marrow disorders, a study suggests. The compounds coax stem cells from bone marrow into the bloodstream where they can be harvested for use in transplantation — and they do so with fewer side effects than drugs now in use.
For patients with blood disorders such as leukaemia, multiple myeloma or non-Hodgkin’s lymphoma, transplantation of haematopoietic stem cells — precursor cells that reside in the bone marrow and give rise to all types of blood cell — can be an effective treatment.
Previous work has shown that prostaglandin E2, or PGE2, a lipid known to regulate multiple bodily reactions including pain, fever and inflammation, also has a role in keeping stem cells in the bone marrow1, 2. In the...
(Excerpt) Read more at nature.com ...
I received a diagnosis of NHL 10 years ago - specifically Stage IV Mantle Cell Lymphoma [MCL].
It is supposed to be fatal within 24 months and others I know who were also being treated have died.
I do not know what chemo treatment they had, but I got VERY High-Dose Hyper-CVAD with Rituxin.
After chemo, I then got an autologous stem-cell transplant [my own stem cells].
They had to harvest my stem cells from my blood ahead of time, so they put me on an aspirin regimen supplemented with injections to boost stem-cell content in my blood.
Apparently, it worked ...
Good for you. Happy to hear that.
Congratulations! I hope you thank your Maker every day.
“Apparently, it worked ...”
Maybe not. Have you checked to see if you are dead?
Bravo and congratulations. Cancer, even at Stage IV, can be beat. You just have to take charge and not be passive about finding and utilizing the best treatments.
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