Boy interrupted: Y-chromosome mutations reveal precariousness of male development

Biology News Net ^ | September 2, 2013 | NA

[Doogle]

"really?"

[Billthedrill]

Yep, that's pretty much it. The lede, that Michael Weiss, MD, PhD, and his colleagues at the university's School of Medicine have determined that the pathway for male sexual development is not as consistent and robust as scientists have always assumed, is pretty deceptive. What the work actually demonstrates is that the process really is as consistent and robust as scientists have concluded, the evidence for which is that the XY female is as rare as it turns out to be.

This says nothing about "gender," which is a latter-day invention of social scientists, and it has nothing to do with homosexuality. This is straight embryology. Here, the scientific fact that a male has an X and a Y chromosome and a female, two X's except in exceedingly rare circumstances flies in the face of the "you are whatever you imagine yourself" vanity we get from the Studies faculties. Breath of fresh air, actually. The reporter may not agree but that's just too bad.

[Age of Reason]

Have you ever noticed that women have a sixth sense that they are being “checked out”. Being old and ugly but not dead, I am amazed how a woman will look around when a guy is admiring her attributes stealthily..

Maybe.

Or it could be that they are constantly looking around to see who's checking them out when you just happen to be doing so.

[Maelstorm]

Sure there are exceptions but the fact that they are rare means they are not to be confused with the overall rule. Male development is NOT precarious for the vast majority of individuals that is the fact since the beginning of humanity. Just as the vast majority of humanity are NOT born with downs syndrome or other forms of genetic anomaly.

[Bigg Red]

Have you ever noticed that women have a sixth sense that they are being “checked out”.

***
I do think that we women have a sense of when we are being watched. Probably some sort of protective mechanism to keep us from harm.

[cradle of freedom]

I think they also took a great deal of grant money from some devious evil people.

[cradle of freedom]

Homos would have been the first to die during the stone age.

[cradle of freedom]

Homos would have been the first to die during the stone age.

[I want the USA back]

This ‘study’ is about a very small number of people. However, it was applied to everyone.
This is poor science.

Also, it’s sex, not gender.

[workerbee]

It is impossible for a male cat to be “calico”

Unlikely, but not impossible.

[Rameumptom]

Nope. they are talking something simple most deer hunters know but gussying it up with too many fancy words. The more food and space there is the more bucks will be born. The less the food and the denser the population the more does will be born.

Men are more likely than women to have birth defects (like color blindness) because they are missing some genes on the missing part of the Y. Females have double insurance against color blindness. So it makes sense that the more stressful the environment for the mother the more likely things are to go wrong for the male.

then of course they had to add in the pc dribble

[NoCmpromiz]

It is impossible for a male cat to be “calico”

Ummm.. not really impossible.

They're just extremely rare and mostly sterile...

This from that bastion of all information that is mostly true, Wikipedia..

Calico cats are almost always female because the X chromosome determines the color of the cat and female cats, 
much like all female mammals, have two X chromosomes, whereas male mammals, including common male cats, have 
one X and one Y chromosome. Since the Y chromosome does not have any color genes, there is no chance he could 
have both orange and non-orange together. One main exception to this is when, in rare cases, a male has XXY 
chromosomes (see Klinefelter's syndrome), in which case the male could have tortoiseshell or calico markings. 
Male calico or tortoiseshell cats are sterile due to the abnormality of carrying two X chromosomes. Few of 
these males can breed (1 in 3,000) and are rejected by breeders for studding purposes and would, in any event, 
pass on only one of those X chromosomes to any male offspring, producing normal (non-calico) male kittens.

[Farnsworth]

HA!

[editor-surveyor]

The info that I got on this way back in the ‘70s was that an X chromosome can only provide two colors, and thus a female has no problem having abundant colors.

Yes, I have seen two male calicos, and I am 68 years old.

[Fire_on_High]

For a full, healthy male cat, yes. Genetic chimerism can account for it, or Kleinfelter’s (XXY).

Red and black are carried on the X chromosome, one or the other but not both. Calicos are normally female because XX means one chromosome carries the gene for red fur, one for black fur. The white patches are a different issue entirely and don’t have anything to do with this.

A genetic chimera has cells from two different animals in the same actual living beast, such as twins fused in utero. One can carry red, one black, and still be full male.

Kleinfelter’s is obvious...two X chromosomes, one can carry red and one black.

So not quite impossible...but a lot of stuff has to go wrong “just so”.

[1010RD]

And why polygyny is the norm in so many mammals.

[tekcomputers]

It’s not stupidity, but it’s not pseudo-science either.

If you want to see pseudo science you should look at any of the post that attempt to paint whether someone is born as male or female determined based on the presence of a Y chromosome..... THAT is pseudo-science. What is being seen is that it’s not nearly as simply as that, there are multiple genetic components that need to line up in order for a person to be born “male”. This article is dealing with a case of someone born with a condition known as Sawyer’s syndrome.... in this case the SRY gene trigger is nonfunctional... the SRY gene is what triggers male gonadal development. In such a case the person is born with gonads which may contain ovarian and testicular cells, and are non functional. As a result they do not release the necessary hormones for the development of secondary sexual characteristics and genital development and the person has a female phenotype at birth.

Another example of what can happen is with AIS(partial or complete), in that case the SRY gene is present and testicles develop, but due to an error on the AR gene which is located in the X chromosome the persons sells poorly react or (or in some cases do not react at all) to natural produced androgens from the gonads, and the genitals develop either completely female in appearance or ambiguous testicles do not descend and remain in the abdomen, and usually become even more feminine in appearance at puberty due to unused testosterone getting converted by the body to estrogen, feminizing the person in appearance even more. CAIS women especially will be even curvier withe larger breasts due the higher level of estrogen naturally in their system than what happens with non-CAIS females.

These conditions have existed for quite some time. Likely predating their “recent” diagnosis.... It was merely that we lacked the medical science at the time to fully comprehend what was happening and just made assumptions purely based upon phenotype. (aka, the baby is born with a vagina, so it’s a girl).

Don’t confuse our increase in understanding of what is going on and causes these types of conditions with “pseudo-science”.