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Here's the Biology Direct link & abstract already mentioned. I never went there before. It reminded me of Physorg.com, i.e. the initial webpage link was not stable, defaulting to an error message, then to an error page. Clicking again on the go arrow, the initial webpage returned. At Physorg.com I have to quickly click on the printer friendly version to avoid that routine. Have any of you had that experience?

Mapping the sequence mutations of the 2009 H1N1 influenza A virus neuraminidase relative to drug and antibody binding sites

In this work, we study the consequences of sequence variations of the "2009 H1N1" (swine or Mexican flu) influenza A virus strain neuraminidase for drug treatment and vaccination. We find that it is phylogenetically more closely related to European H1N1 swine flu and H5N1 avian flu rather than to the H1N1 counterparts in the Americas. Homology-based 3D structure modeling reveals that the novel mutations are preferentially located at the protein surface and do not interfere with the active site. The latter is the binding cavity for 3 currently used neuraminidase inhibitors: oseltamivir (Tamiflu(R)), zanamivir (Relenza(R)) and peramivir; thus, the drugs should remain effective for treatment. However, the antigenic regions of the neuramidase relevant for vaccine development, serological typing and passive antibody treatment can differ from those of previous strains and already vary among patients.

Reviewers: This article was reviewed by Sandor Pongor and Aravind Lakshminarayanan Iyer.

I have too many windows open to try to open the pdf link.