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Superbugs Are Outstripping Antibiotics
Townhall.com ^ | March 8, 2015 | Steve Chapman

Posted on 03/08/2015 7:16:20 AM PDT by Kaslin

The old joke about making love to a gorilla is that you don't stop when you're tired; you stop when the gorilla is tired. In modern American agriculture, one of the gorillas is McDonald's, the biggest restaurant chain on Earth. The other day it announced a change for its U.S. outlets that will force suppliers to adapt.

Over the next two years it will stop buying chickens raised with antibiotics that are "important to human medicine." This is a response to complaints from medical groups, scientists and government agencies, who say farmers are eroding the effectiveness of these drugs by overusing them. Adding them to feed as routine growth stimulants speeds the emergence of bacteria they can't kill.

Decisions like the one by McDonald's may help, but much damage is already done. In 2007, a healthy 12-year-old California boy named Carlos Don went off to summer camp and got pneumonia. He was given antibiotics, but his condition got so bad he was put on a ventilator. Eventually he was diagnosed with a strain of staph that is resistant to antibiotics. After two weeks in intensive care, he died.

Last month, seven patients at Ronald Reagan UCLA Medical Center in Los Angeles were infected with a "superbug" blamed on inadequately sterilized equipment, and two of them didn't survive. Four more cases turned up at Cedars-Sinai Medical Center.

These stories will only get more common. Already the federal Centers for Disease Control and Prevention estimates that 2 million Americans contract antibiotic-resistant illnesses each year -- and 23,000 die, despite the best efforts of 21st-century physicians deploying space-age technology.

These patients find themselves flung back into the world of our ancestors, before the discovery of penicillin, when infections were often deadly and medicine had few reliable means of treating them. Exceptionally virulent strains also pose a dire hazard to patients who need organ transplants or other surgery.

Most of the proposed remedies for this problem involve curbing the unnecessary application of these drugs. The federal Food and Drug Administration has a campaign to persuade agribusiness companies to stop using them to enhance growth and reduce feed costs. Sen. Dianne Feinstein, D-Calif., has proposed phasing out all use of antibiotics in animals for non-therapeutic purposes.

What is overlooked is that the looming shortage of effective antibiotics, like every shortage, has not only a demand component, but a supply component. Curbing their use, though helpful, only postpones the day when existing antibiotics lose their potency.

Every antibiotic, given the ability of bacteria to evolve rapidly to survive, is bound to become ineffective sooner or later. The trick is to ensure a steady stream of new drugs that the resistant microbes have never encountered before. We need medical science to advance more rapidly than the bacteria do.

But lately, it hasn't. Henry I. Miller, a physician and molecular biologist at Stanford's Hoover Institution, says one culprit is obvious. In 2002, the FDA established new rules for the clinical trials used to test new antibiotics -- doubling the number of patients required, thus making drug development harder and more expensive.

Since then, he says, many of the big pharmaceutical companies have given up research and development on antibiotics. Clinical trials have grown rare. "New antibiotic development has slowed to a standstill," says the Infectious Diseases Society of America.

Research on antibiotics is especially vulnerable to overregulation because they are so much less profitable than many other medicines. Unlike new drugs that patients take permanently for chronic ailments, which produce mighty rivers of revenue, antibiotics usually don't sell at a high price and aren't needed for long.

Pfizer's most lucrative antibiotic has sales of $2 billion a year, according to Emory University economist Paul H. Rubin, writing in Regulation magazine. Its Lipitor, which is prescribed to lower blood cholesterol, pulled in $9 billion a year before its patent expired. Rubin notes that steps to reduce the use of antibiotics have the perverse effect of making them even less lucrative.

Even the FDA has had to acknowledge its role as an impediment. Last year, Janet Woodcock, director of its Center for Drug Evaluation and Research, told Congress that "streamlined development pathways will likely be needed to improve the climate" and that the agency "is working hard to streamline requirements for clinical trials for studying new antibacterial drugs." She has also endorsed legislation to allow smaller clinical trials for potent antibiotics.

Bacteria can evolve. So can McDonald's. Maybe federal policymakers can as well, before it's too late.


TOPICS:
KEYWORDS: drugs; mcdonalds
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1 posted on 03/08/2015 7:16:20 AM PDT by Kaslin
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To: Kaslin

Several questions arise. Do antibiotics stay active in the chicken’s flesh forever? Do the bacteria strains in the chickens pose a threat to humans? Has any person died from a super bug as a result of eating chicken treated with antibiotics?


2 posted on 03/08/2015 7:33:09 AM PDT by Right Brother
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To: Kaslin

Lost me in the first sentence. Keep your bestiality fantasies to yourself, Steve.


3 posted on 03/08/2015 7:36:01 AM PDT by Tax-chick (Wash, rinse, dry, put away.)
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To: Right Brother

The answer is no. ALL animals must be withdrawn from use of antibiotics both in feed and for treatment such that they have cleared the animal’s system prior to slaughter.

They are routinely tested for residue, no exceptions.


4 posted on 03/08/2015 7:39:03 AM PDT by traderrob6
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To: Tax-chick

I was thinking the same thing.


5 posted on 03/08/2015 7:41:16 AM PDT by NotSoFreeStater (If you choose not to decide you still have made a choice)
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To: Kaslin

The cause of so called “superbugs”s is twofold.....Over prescribing antibiotics by doctors and improper adminstiration and usage by patients.


6 posted on 03/08/2015 7:44:18 AM PDT by traderrob6
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To: Right Brother

I don’t think these are the right questions. It’s not a matter of eating superbug-infected chicken: I’m thinking that rarely happens. But it’s a question of, can the superbugs infesting this chicken migrate to humans at ANY step of processing —— the farm’s human workforce, the slaughterhouse workers, the meat-packers -— and from there, migrate person to person? It just takes ONE exposed person -— Patient 0 (Zero), as the epidemiologists would say —— for a bug to enter the human population and then poliferate rapidly.


7 posted on 03/08/2015 7:46:03 AM PDT by Mrs. Don-o ("The trouble ain't what people don't know: it's what they DO know that ain't so." - Will Rogers)
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To: traderrob6

“...80 percent of all antibiotics sold in the United States are for use on livestock and poultry, not humans...”

http://www.nrdc.org/food/saving-antibiotics.asp


8 posted on 03/08/2015 8:06:22 AM PDT by JohnG45
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To: Kaslin; Mrs. Don-o
Every antibiotic, given the ability of bacteria to evolve rapidly to survive, is bound to become ineffective sooner or later. The trick is to ensure a steady stream of new drugs that the resistant microbes have never encountered before. We need medical science to advance more rapidly than the bacteria do.

First: My understanding is that there is a new class of antibiotics on the way. Second: "The trick" is to rotate the use of antibiotics, so as not to keep using the same chemistry everywhere, such that when the superbugs lose their adaptation to any one of them one can go back to the others.

9 posted on 03/08/2015 8:12:22 AM PDT by Carry_Okie (Democrats: the Party of slavery to the immensely wealthy for over 200 years.)
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To: Kaslin
I currently have 2 people (1 family member and a friend) who are fighting for their lives with infections that are not responding to anti-biotics....

I have the family member now on Manuka Honey with a UMF® of (Unique Manuka Factor) of +16, and lots of prayers. I have a jar set aside for my friend for the next time I see him.

I pray this meets or exceeds expectations...

10 posted on 03/08/2015 8:20:53 AM PDT by Dubh_Ghlase
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To: Right Brother

When I was trying to figure it out, I read and heard that the antibiotics settle in the fat. So, non-fat milk and meats with next to no fat content are okay. But who knows? With nutrition, what’s true changes every day.


11 posted on 03/08/2015 8:21:33 AM PDT by grania
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To: JohnG45

That sounds about right and I have made to contention otherwise. What’s your point?


12 posted on 03/08/2015 8:28:03 AM PDT by traderrob6
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To: Right Brother

FWIW, the problem is not primarily about bacteria in chickens getting to humans. The problem is that by over-using antibiotics, we are helping bacteria breed immunity to the antibiotics that we have (and we’re not creating new ones fast enough to keep up). It would probably be better to leave the “weak” bacteria alone so that our tools can kill them when we need to.


13 posted on 03/08/2015 8:39:22 AM PDT by Darth Reardon (Is it any wonder I'm not the president?)
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To: Kaslin

Does anyone remember when Hexachlorophene was banned in the early ‘70s and there was a huge outbreak of strep infections which then became more and more difficult to treat with antibiotics?

A couple more anti-microbials that have been recently banned are Benzalkonium Chloride and now Tricolsan.

Allegedly, these “might” present an environmental hazard, and that’s way more important than mere human beings.


14 posted on 03/08/2015 8:53:05 AM PDT by JJ_Folderol (Diagonally parked in a parallel universe...)
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To: traderrob6
What’s your point?

My point is that the sources of superbugs are manifold and not only the over-prescription of antibiotics by physicians.

Did I have to spell that out for you?

15 posted on 03/08/2015 8:57:58 AM PDT by JohnG45
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To: JohnG45

No need to get snippy. I don’t see how your original post illustrates your point.

Has there ever been a documented case of a superbug passed from animal to human?


16 posted on 03/08/2015 9:14:57 AM PDT by traderrob6
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To: traderrob6
I don’t see how your original post illustrates your point.

Did you bother to read the source I posted?

17 posted on 03/08/2015 9:22:40 AM PDT by JohnG45
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To: JohnG45

I did. Replete with speculation and conjecture based on a few facts. Definately smacks of propaganda pushing an agenda.

The fact that the majority of antibiotics used are for animal husbandry puposes proves nothing and certainly no causation


18 posted on 03/08/2015 9:44:37 AM PDT by traderrob6
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To: Dubh_Ghlase

If you wouldn’t mind, would you explain more about what you are doing with the Maunka? Internally, externally or both?

These people are in the hospital I take it?


19 posted on 03/08/2015 9:54:09 AM PDT by beaversmom
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To: traderrob6

Get help for your tunnel vision.


20 posted on 03/08/2015 9:57:57 AM PDT by JohnG45
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