Posted on 03/04/2021 12:41:20 PM PST by Red Badger
In correspondence published in The New England Journal of Medicine, researchers from Massachusetts General Hospital note that Phase 3 clinical data from the Moderna vaccine trial did show delayed skin hypersensitivity in a small number of the more than 30,000 trial participants. However, the authors say the large, red, sometimes raised, itchy or painful skin reactions were never fully characterized or explained, and they warn clinicians may not be prepared to recognize them and guide patients on treatment options and completion of the second dose of the vaccine. Credit: Massachusetts General Hospital
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These reactions should not discourage patients from getting the vaccine, say researchers at Massachusetts General Hospital.
As the speed and scale of vaccinations against the SARS-CoV-2 virus ramps up globally, researchers at Massachusetts General Hospital (MGH) are calling for greater awareness and communication around a delayed injection-site reaction that can occur in some patients who have received the Moderna mRNA-1273 vaccine.
In a letter to the editor published online in The New England Journal of Medicine (NEJM), the authors note Phase 3 clinical data from the Moderna vaccine trial did show delayed skin hypersensitivity in a small number of the more than 30,000 trial participants. However, the authors say the large, red, sometimes raised, itchy or painful skin reactions were never fully characterized or explained, and they warn clinicians may not be prepared to recognize them and guide patients on treatment options and completion of the second dose of the vaccine.
“Whether you’ve experienced a rash at the injection site right away or this delayed skin reaction, neither condition should prevent you from getting the second dose of the vaccine,” says Kimberly Blumenthal, MD, MSc, lead author of the letter and co-director of the Clinical Epidemiology Program in the division of Rheumatology, Allergy and Immunology at MGH. “Our immediate goal is to make physicians and other care providers aware of this possible delayed reaction, so they are not alarmed, but instead well-informed and equipped to advise their patients accordingly.”
In the letter, Blumenthal and her co-authors also note their own clinical observations of the delayed, large, local reactions to the Moderna vaccine, and report on a series of 12 patients with the reactions. In that group, symptom onset ranged from four days after the first dose up to 11 days post-vaccination, with a median onset of symptoms on day eight. Photographs show the varied size and severity of the reactions. Most patients were treated with ice and antihistamines, although some required corticosteroids and one was erroneously treated with antibiotics.
“Delayed cutaneous hypersensitivity could be confused – by clinicians and patients alike – with a skin infection,” says letter co-author Erica Shenoy, MD, PhD, associate chief of the MGH Infection Control Unit. “These types of reactions, however, are not infectious and thus should not be treated with antibiotics.”
On average, symptoms cleared up after nearly a week for the group of 12 reported in the letter. Half of the patients went on to experience a reaction after the second dose – at or around 48 hours post-vaccination. No patient experienced a dose two reaction that was more severe than their dose one reaction.
The authors also say samples taken from skin biopsies confirmed their suspicion of a delayed allergic immune response that is commonly seen in drug reactions.
“For most people who are experiencing this, we believe it’s tied to the body’s immune system going to work,” says Esther Freeman, MD, PhD, director of Global Health Dermatology at MGH and co-author of the NEJM letter. “Overall, this data is reassuring and should not discourage people from getting the vaccine.”
Reference: “Delayed Large Local Reactions to mRNA-1273 Vaccine against SARS-CoV-2” by Kimberly G. Blumenthal, M.D.; Esther E. Freeman, M.D., Ph.D.; Rebecca R. Saff, M.D., Ph.D.; Lacey B. Robinson, M.D., M.P.H.; Anna R. Wolfson, M.D.; Ruth K. Foreman, M.D., Ph.D.; Dean Hashimoto, M.D.; Aleena Banerji, M.D.; Lily Li, M.D.; Sara Anvari, M.D. and Erica S. Shenoy, M.D., Ph.D., 3 March 2021, New England Journal of Medicine. DOI: 10.1056/NEJMc2102131
To learn more about potentially allergic reactions after COVID-19 vaccination, MGH Allergy is collecting all immediate and delayed reactions in a designated registry.
Additional co-authors of the NEJM letter were Aleena Banerji, MD, Ruth Foreman, MD, PhD, Dean Hashimoto, MD, Lacey Robinson, MD, MPH, Rebecca Saff, MD, and Anna Wolfson, MD, all from MGH; Lily Li, MD, of Brigham and Women’s Hospital; and Sara Anvari, MD, MSc, Baylor College of Medicine, Texas Children’s Hospital.
People who are prone to allergic reactions (me) should not get the Moderna vaccine. My dad who doesn’t have my allergies got it with no problems.
Ping
Everyone says that and then they see the tiny little 25 gauge needle we’re actually using and they pleasantly surprised. Most people say they didn’t even feel it. It’s a tiny needle and, incidentally, the bore of a 25 gauge needle is about half the size of the smallest known microchip. a little FYI there.
You do that.
We have to pay them like they know, whether they do or not.
Doctors and Lawyers: two professions that can make you pay them when they fail.
Now, is there a tutorial wrapped inside that lipid packet?
Or, is it just a piece of junk RNA that is dumber than a bag of rocks?
this entire fiasco is a criminal political medical expt.
the virus: bioweapon by CDC and FauXi
the room: Wuhan run by Xi, Pfizer, and your taxes (Biden).
the plan: infect, inject, enemy (USA and world) dies.
the response: inept, useless, helpful to the enemy.
the DNA operating system: patented years ago,
with the code released by the CCP in 2019.
the result: voila, and this is only a few weeks,
and royalties GALORE to CDC and FauXi (big payoffs)
the injured: no rights to sue.
the DNC, DOJ, CCP plan: they won, and we dont know
the tenth of it.
I had the 2nd Moderno over two weeks ago and had zero side effects.
Large local reactions almost never go on to anaphylaxis. This appears to be a know. side effect with moderna my dad got a small reaction with his first just had the second with no problem. It should not stop you from getting the vaccine
I have two blown out disks right now from a work related injury. Every time I cough or sneeze, it about puts me on my knees. I’m in constant pain really and after the cough or sneeze, when the pain subsides, it doesn’t subside to where it was before the cough or sneeze. It’s worse. Covid would be the death of me, I have no doubt. The choice was real easy for me.
Well, it’s felt like it was pretty darn close a few times.
Besides, that doesn’t mean that the NEXT time it won’t be.
I have MCAD and I an NOT getting injected with anything that isn’t required for survival. If it’s a matter of life and death and I’m under medical care where they can treat a bad reaction, that changes things.
But if I have a bad reaction to something, it’s not the medical professionals who will be up with me at night, or transporting me to the hospital, or paying for it.
I have to live in this body , not them. I have to deal with the bad reactions, not them.
I’m passing.
I actually got what appears to be the same rash from my 2nd Pfizer shot on the 2nd day.
It itched like heck, and my Rn Wife put Cortisone 10 with Aloe over the red stuff and 3 days later it was over.
It never hurt just swelled up, turned red and itched like he**!
According to a nurse friend at the PPO, “Good now you had a good reaction to your shot!”
My wife just wanted to sleep all day between treating my arm. I just wanted to scratch the shot area.
I understand. Everyone has to do what they feel is the best thing for their health. However Reagan warned us, if totalitarianism come to America, it will most likely come through our medical system.
everyone has to decide what’s best for them. I was just saying a large local reaction rarely progresses to anaphylaxis. Stay well FRiend
I thought it was “If fascism ever comes to America, it will come in the name of liberalism.” That’s something I’ll bet you and I agree on.
Bee stings. Remove stinger with a knife , credit card, or other edged item. Scrap it off, treat it like a pimple so you don’t inject more venom. You can place an aspirin covered by a bandaid over the sting site. In an emergency remove stinger as advised above, look around for a cigarette butt. Remove all the paper and filter. Place tobacco over sting site. Hope this helps🤗
I’m among the MANY MILLIONS OF AMERICANS who have received the Moderna vaccine with the only side effect a mildly sore arm for several days. My wife and I have both received the first dose and are scheduled to receive the second dose next week.
Same here - 76-year old female, second Moderna shot was two weeks ago yesterday. No side effects.
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