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Keyword: apoptosis

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  • Programmed cell death activates latent herpesviruses

    09/06/2013 1:59:26 PM PDT · by neverdem · 13 replies
    Biology News Net ^ | September 5, 2013 | NA
    Researchers have found that apoptosis, a natural process of programmed cell death, can reactivate latent herpesviruses in the dying cell. The results of their research, which could have broad clinical significance since many cancer chemotherapies cause apoptosis, was published ahead of print in the Journal of Virology. Human herpesviruses (HHV) are linked to a range of childhood and adult diseases, including chickenpox, mononucleosis, cold sores, and genital sores, and are of a particular concern for patients who are immunosuppressed due cancer or AIDS. Some HHV types are so common they are nearly universal in humans. A key feature of these...
  • Small-molecule drug drives cancer cells to suicide

    02/07/2013 2:12:52 PM PST · by neverdem · 8 replies
    Nature News ^ | 07 February 2013 | Zoe Cormier
    Studies in mice show therapy is effective even in hard-to-treat brain tumours. Cancer researchers have pinned down a molecule that can kick-start the body’s own tumour-destroying systems, triggering cell death in cancerous but not healthy tissue in mice. The molecule, TIC10, activates the gene for a protein called TRAIL (tumour-necrosis-factor-related apoptosis-inducing ligand), which has long been a target for cancer researchers looking for drugs that would avoid the debilitating effects of conventional therapies. “TRAIL is a part of our immune system: all of us with functional immune systems use this molecule to keep tumours from forming or spreading, so boosting...
  • Caught in the act: Researchers capture key moments in cell death

    02/02/2013 9:44:18 PM PST · by neverdem · 8 replies
    Phys.org ^ | February 2, 2013 | NA
    Scientists at the Walter and Eliza Hall Institute have for the first time visualised the molecular changes in a critical cell death protein that force cells to die. The finding provides important insights into how cell death occurs, and could lead to new classes of medicines that control whether diseased cells live or die. Cell death, called apoptosis, is important for controlling the number of cells in the body. Defects in cell death have been linked to the development of diseases such as cancer and neurodegenerative conditions. Insufficient cell death can cause cancer by allowing cells to become immortal while...
  • Scientists discover cause of destructive inflammations

    03/03/2010 6:28:41 AM PST · by decimon · 41 replies · 744+ views
    The signaling molecule CD95L, known as "death messenger," causes an inflammatory process in injured tissue after spinal cord injuries and prevents its healing. This discovery was published by scientists of the German Cancer Research Center. In mice, the researchers found out that if they switch off CD95L, the injured spinal cord heals and the animals regain better ability to move. Therefore, substances which block the death messenger might offer a new approach in the treatment of severe inflammatory diseases. A couple of years ago, Dr. Ana Martin-Villalba of the German Cancer Research Center already succeeded in reducing the effects of...
  • Bacteria tails could protect against 'dirty' bomb

    04/11/2008 6:20:19 AM PDT · by TigerLikesRooster · 18 replies · 67+ views
    New Scientist ^ | 04/11/08 | Debora MacKenzie
    Bacteria tails could protect against 'dirty' bomb 13:55 11 April 2008 NewScientist.com news service Debora MacKenzie A drug made out of Salmonella can protect mice and monkeys from high doses of radiation. It might help protect rescuers who have to enter a radioactive area after attack with a nuclear or "dirty" bomb, and also cancer patients undergoing radiation therapy. People die of radiation sickness when radiation kills cells lining the gut, as well as those in the bone marrow that gives rise to vital blood cells. The cells die because radiation activates the natural programme of cell death, apoptosis. Andrei...
  • St. Jude researchers find key step in programmed cell death (news release)

    03/01/2008 11:15:51 AM PST · by Ernest_at_the_Beach · 4 replies · 113+ views
    www.stjude.org ^ | February 29, 2008 | James Ihle, Ph.D
    The discovery provides insight into how certain proteins, including Hax1, work and how they control the process of apoptosis. Investigators at St. Jude Children’s Research Hospital have discovered a dance of proteins that protects certain cells from undergoing apoptosis, also known as programmed cell death. Understanding the fine points of apoptosis is important to researchers seeking ways to control this process.In a series of experiments, St. Jude researchers found that if any one of three molecules is missing, certain cells lose the ability to protect themselves from apoptosis. A report on this work appears in the advance online publication of...
  • The Red-Hot Power Of Chillies Can Kill Cancer

    03/16/2006 5:05:15 PM PST · by blam · 23 replies · 1,767+ views
    The Telegraph (UK) ^ | 3-16-2006 | Roger Highfield
    The red-hot power of chillies can kill cancer By Roger Highfield, Science Editor (Filed: 16/03/2006) The substance in chillies that causes the tongue to burn also drives prostate cancer cells to kill themselves, according to research that could pave the way for new treatments. The pepper component capsaicin makes the cells undergo programmed cell death or apoptosis, says a study published in the journal Cancer Research. High intake of hot chillis has been linked to stomach cancer Tests found that it induced approximately 80 per cent of cancer cells growing in mice to follow the molecular pathways leading to apoptosis....