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Stress is inevitable. Chronic stress can increase our risk for heart disease and may also help cancer spread. How this works has remained a mystery. They discovered that stress causes certain white blood cells called neutrophils to form sticky web-like structures that make body tissues more susceptible to metastasis. The finding could point to new treatment strategies that stop cancer's spread. The team arrived at their discovery by mimicking chronic stress in mice with cancer. They first removed tumors that had been growing in mice's breasts and spreading cancer cells to their lungs. Next, they exposed the mice to stress....

A study of people with obstructive sleep apnea suggests that high CPAP pressures may explain why the machines do not lower a patient's risk of heart disease, which is about two to three times higher than average. Several years ago, studies started to suggest a problem with this hypothesis. In studies designed to understand CPAP's effect on the body, they found that levels of a pro-inflammatory factor, angiopoietin-2, do not decline with CPAP use. High levels of Ang2 have been linked in previous studies to a higher risk of stroke, coronary artery disease, vascular disease, and mortality. …To Jelic, the...

— Americans consume too much vitamin B3, researchers suggestNiacin metabolism was associated with incident major adverse cardiovascular events (MACE) and may be linked to the pathogenesis of heart disease via inflammatory pathways, researchers said. In a metabolomics study of stable cardiovascular patients, two terminal metabolites of niacin -- N1-methyl-2-pyridone-5-carboxamide (2PY) and N1-methyl-4-pyridone-3-carboxamide (4PY) -- were associated with an up to twofold increased risk of cardiovascular disease (CVD) independent of traditional risk factors, reported Stanley Hazen, MD, PhD, of Cleveland Clinic, and colleagues. Moreover, both metabolites have genetic links to vascular inflammation, they noted in Nature Medicineopens in a new tab...

An international academic consortium has identified 13 biomarkers that significantly improve the ability to accurately predict cardiovascular disease risk in people with type 2 diabetes. The analysis, conducted by 23 experts from 11 countries, was led by The Johns Hopkins University in the United States, the Chinese University of Hong Kong in Hong Kong, and Lund University in Sweden. Although people with type 2 diabetes are two times more likely to develop cardiovascular disease than those without diabetes, it is a challenge for clinicians to predict who in this population is most at risk. Traditional risk scores, which reflect risk...

A troubling trend in Americans’ heart health is emerging, and doctors are aiming to bring more awareness to the problem. While death rates from infective endocarditis have generally declined across the U.S. over the past two decades, they have alarmingly increased among young adults aged 25 to 44. This research, published in the Journal of the American Heart Association, underscores a public health issue that intersects with the ongoing opioid crisis. Infective endocarditis, often referred to as bacterial endocarditis, is a rare but serious condition where bacteria enter the bloodstream and infect the heart lining, valves, or blood vessels. It...

Since mutilating and disfiguring the genitals of minors, chopping off children’s healthy body parts in Mengele-type experimental surgeries, and injecting human beings with synthetic cross-sex hormones to affirm a debilitating mental delusion apparently weren’t enough to compel the left to drop the “gender”-bending madness, I doubt the findings of a new study from Denmark will be either—although they should. According to a new article out at Slay News by David Lindfield:The risk of heart disease is soaring among the growing number of transgenders being prescribed life-altering hormone drugs.…A new study published in the peer-reviewed European Journal of Endocrinology revealed that...

A little pill called Captagon turns Jihadists into superhuman soldiers. They dont feel pain, they dont fear death and they dont get tired. They become killing machines. Bonus; it makes them murderously psychotic and causes brain damage after prolonged use. It is cheap, easy to produce and highly addictive. The Syrians take it as do the rebels. And from what I hear, ISIS loves the stuff. They laugh when they are beaten, they are high when they rape, they are jazzed when they behead infidels. During the raid in Paris, French police said they found needles used by the attackers...

"Bad" cholesterol isn't the only culprit linked with a higher risk of cardiovascular disease, according to a trio of recent studies showing that a different kind of cholesterol is also a strong risk factor for people worldwide. Remnant cholesterol (RC) was confirmed as a strong risk factor for coronary heart disease, heart attacks and stroke, the largest of the studies showed. RC is produced from the metabolism of triglycerides. Using data from almost one million participants—the findings are the first to show, on a large scale, a causal link between high RC and risk of cardiovascular illness. "This tells us...

In some ways, the link between viruses, vaccines and heart health is simple. Think of your heart as a house, said Dr. Jorge Alvarez, an interventional cardiologist at Methodist Cardiology Clinic of San Antonio. "You have the walls of your house, which are like the walls of your heart. You have the doors, which are the valves. And then you have plumbing and electricity. "A virus can affect all of those aspects of your house," he said. That makes being vaccinated against COVID-19, flu and other illnesses an important way for people with heart disease to protect themselves. That fact...

Forget walking 10,000 steps a day. Taking at least 50 steps climbing stairs each day could significantly slash your risk of heart disease, according to a new study. The study, published in Atherosclerosis, found that climbing more than five flights of stairs daily could reduce risk of cardiovascular disease by 20%. Atherosclerotic cardiovascular disease (ASCVD) along with coronary artery disease and stroke are the leading causes of morbidity and mortality worldwide. "Short bursts of high-intensity stair climbing are a time-efficient way to improve cardiorespiratory fitness and lipid profile, especially among those unable to achieve the current physical activity recommendations," said...

The sound of airplanes flying overhead late at night is linked to a slight increase in hospital admissions for heart-related problems the following day, a study suggests. Researchers combined hospital admissions and mortality data with environmental modeling to assess short-term associations between aircraft noise and cardiovascular events the following day in a population of 6.3 million residing near Heathrow Airport between 2014-2018. Risks of airplane noise They found that a 10 decibel increase in noise during the previous evening and previous early morning was associated with a small increase in risk for all cardiovascular disease admissions. This risk was most...

About 3 million Americans live with cardiovascular pacemakers. But over time, scar tissue or blood clots can form around the leads, or wires, that carry the electrical impulses from the pacemaker to the heart. Scar tissue or clots may hinder the flow of blood, potentially resulting in swollen extremities or pain. However, the incidence and clinical impact of such lead-related venous obstruction, or LRVO, among patients with pacemaker devices is not well characterized. Physician-researchers found that the incidence of symptomatic LRVO among patients implanted with cardiovascular implantable electronic devices to be four times higher than previously reported—with only a minority...

In a world-first randomized study, catheter ablation has been shown to reverse heart failure with preserved ejection fraction (HFpEF) in patients with both HFpEF and atrial fibrillation (AF). Researchers found catheter ablation substantially improved exercise capacity, lung pressure and quality of life in participants, and significantly, 50% of participants randomized to the study group no longer met the criteria for a HFpEF diagnosis. Dr. David Chieng said that catheter ablation should be considered as a treatment option for those with AF and HFpEF. "After catheter ablation, half of our study patients showed reversal of HFpEF using the gold standard testing...

The largest study to examine outcomes for patients treated with a minimally invasive procedure to repair a poorly functioning mitral valve in the heart found that the procedure was safe and resulted in a successful repair for nearly 9 out of 10 patients, researchers reported. Patients whose procedure was successful were half as likely to die within one year. "Our analysis showed that in an older patient population with limited therapeutic options, transcatheter-based mitral valve repair was safe and was effective in reducing valve leakage from severe to moderate or less in almost 90% of patients," said Raj R. Makkar,...

A new study suggests that a "keto-like" diet may be associated with higher blood levels of "bad" cholesterol and a twofold heightened risk of cardiovascular events such as chest pain (angina), blocked arteries requiring stenting, heart attacks and strokes. Proponents of a ketogenic diet suggest limiting carbohydrates to 10% of total daily calories, protein to 20% to 30% and obtaining 60% to 80% of daily calories from fat. Some previous studies have shown that an LCHF diet can lead to elevated levels of LDL cholesterol in some people. Iatan and her colleagues defined an LCHF diet as consisting of no...

Researchers are announcing dramatic results that demonstrate a significant improvement in cardiovascular outcomes among patients who received access to a novel educational and support intervention called MOXIE. The randomized trial is the largest study on record for a tailored patient engagement approach, showing a statistically significant reduction in clinical outcomes like hospitalizations. 4,761 participants who were ≥65 years of age and at high risk of cardiovascular disease (having one or more of coronary artery disease, stroke, chronic kidney disease, heart failure or two or more of current smoking, diabetes, hypertension, high cholesterol) were randomized to receive MOXIE or to receive...

Heart failure is often identified only when the heart has already deteriorated. This is in large part because the cause is unknown for about 70% of people who experience heart failure. Researchers have discovered that one of the earliest signs of heart failure is a change in how the heart produces energy, with findings offering a potential way to preempt heart failure before the heart begins to deteriorate. Led by Dr. Paul Delgado-Olguín, the research may help explain the diversity of causes underlying heart failure. "We were surprised to find that dysregulation of energy production was the earliest sign of...

According to the findings of randomized controlled trials, blood lipid levels in patients with coronary heart disease (CHD) can be significantly decreased through a combination of pitavastatin and ezetimibe; however, the effects and clinical applications of this treatment remain controversial. An article objectively assesses the efficacy and safety of pitavastatin and ezetimibe in lowering blood lipid levels. Relevant studies were retrieved from electronic databases. The levels of low-density lipoprotein cholesterol, total cholesterol, triglycerides, and high-density lipoprotein cholesterol in patients' serum after treatment were the primary endpoint. Nine randomized controlled trials (2586 patients) met the inclusion criteria. The meta-analysis indicated that...

At a memorial event—held in their home town of Fayetteville, North Carolina on January 17—remarks by the surviving sister, Herneitha Rochelle Richardson, have sparked confusion over the nature of her death, and whether it is being attributed to the COVID-19 vaccine. SNIP Neither sister appear to have publicly said whether they were vaccinated or not. However, the reaction to Richardson's memorial speech suggests others believe they were, though she does not mention the vaccine explicitly. "Don't you dare call me a conspiracy theorist, because I saw it happen," Richardson said. "I saw how it happened. I was there when it...

COVID Boosters Trigger Metastasis Patient after patient in stable remission are now suddenly experiencing an explosive relapse Oncology doctors are sounding the alarm – the COVID boosters appear to be triggering metastasis. Patient after patient in stable remission are now suddenly experiencing an explosive relapse, triggering the appearance of new tumors just days or weeks after being forced to have a booster. STORY AT-A-GLANCE Cancer rates have increased since the introduction of the COVID shots and is now one of the top three leading causes of premature death among younger adults — a trend that in turn is driving down...