Keyword: ipsc

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  • Cellular Reprogramming Picks Up Speed

    09/20/2013 4:27:39 PM PDT · by neverdem · 5 replies
    ScienceNOW ^ | 2013-09-18 | Gretchen Vogel
    J. Hanna/Weizmann InstituteImproved recipe. After 6 days of reprogramming, nearly 100% cells that lack Mbd3 (right) have become reprogrammed (yellow). Few unaltered cells (left) have made the transition, remaining red. Given the right instructions in the lab, mature cells can turn back into embryoniclike ones that researchers covet, but the process is frustratingly slow and inefficient. By removing a molecular brake, scientists have now figured out how to reprogram cells with almost 100% efficiency.In a process called cellular reprogramming, researchers increase the expression of four genes in skin, blood, or other mature cells to turn them into induced pluripotent stem...
  • Cells Reprogrammed in Living Mice

    09/12/2013 6:34:31 PM PDT · by neverdem · 1 replies
    ScienceNOW ^ | 2013-09-11 | Gretchen Vogel
    Sagrario Ortega/Spanish National Cancer Research Center (CNIO), MadridPregnant with possibilities. Cells reprogrammed in living mice (green) can contribute to both the placenta and body tissues of a developing mouse. Cells Reprogrammed in Living Mice Researchers have discovered a surprisingly effective way to “reprogram” mature mouse cells into an embryolike state, able to become any of the body’s cell types. Their recipe: Let the transformation happen in a living animal instead of a petri dish. The finding could help scientists better understand how reprogramming works and it may one day help breed replacement tissues or organs in the lab—or in patients.In...
  • Stem cells mimic human brain

    08/28/2013 7:01:48 PM PDT · by neverdem · 7 replies
    Nature News ^ | 28 August 2013 | Helen Shen
    'Mini-brains' help researchers to study neurological diseases in living human tissue. With the right mix of nutrients and a little bit of coaxing, human stem cells derived from skin can assemble spontaneously into brain-like chunks of tissue. Researchers provide the first description and application of these ‘mini-brains’ today in Nature1. “It’s a seminal study to making a brain in a dish,” says Clive Svendsen, a neurobiologist at the University of California, Los Angeles, who was not involved in the study. “That’s phenomenal.” A fully formed artificial brain might still be years away, he notes, but the pea-sized neural clumps developed...
  • Stem cells: Egg engineers

    08/28/2013 5:24:57 PM PDT · by neverdem · 2 replies
    Nature News | 21 August 2013 | David Cyranoski
    In a technical tour de force, Japanese researchers created eggs and sperm in the laboratory. Now, scientists have to determine how to use those cells safely — and ethically. Since last October, molecular biologist Katsuhiko Hayashi has received around a dozen e-mails from couples, most of them middle-aged, who are desperate for one thing: a baby. One menopausal woman from England offered to come to his laboratory at Kyoto University in Japan in the hope that he could help her to conceive a child. “That is my only wish,” she wrote. The requests started trickling in after Hayashi published the...
  • New teeth grown from urine - study

    07/30/2013 10:25:53 AM PDT · by Red Badger · 62 replies
    BBC ^ | 29 July 2013 Last updated at 19:44 ET | By James Gallagher
    Scientists have grown rudimentary teeth out of the most unlikely of sources, human urine. The results, published in Cell Regeneration Journal, showed that urine could be used as a source of stem cells that in turn could be grown into tiny tooth-like structures. The team from China hopes the technique could be developed into a way of replacing lost teeth. Other stem cell researchers caution that that goal faces many challenges. Teams of researchers around the world are looking for ways of growing new teeth to replace those lost with age and poor dental hygiene. Stem cells - the master...
  • Researchers Identify Proteins Key in Stem Cell Production

    07/29/2013 10:02:49 PM PDT · by neverdem · 1 replies ^ | Jul 8, 2013 | Sergio Prostak
    A multinational team of scientists led by Prof Benjamin Blencowe from the University of Toronto has identified proteins that play a key role in controlling pluripotency, which may mean a potential breakthrough in producing the so-called induced pluripotent stem cells.Colonies of the induced pluripotent stem cells (Boston University Center for Regenerative Medicine) Induced pluripotent stem cells can be of great value for medical research because they can flexibly develop into many different types of cells. However, producing these cells is challenging because the proteins that control their generation are largely unknown.The team discovered the proteins using the splicing code developed...
  • Researchers turn off Down’s syndrome genes

    07/28/2013 10:42:07 PM PDT · by neverdem · 12 replies
    Nature News ^ | 17 July 2013 | Beth Mole
    Silencing extra chromosome in cell cultures could lead to new treatments for the disorder. The insertion of one gene can muzzle the extra copy of chromosome 21 that causes Down’s syndrome, according to a study published today in Nature1. The method could help researchers to identify the cellular pathways behind the disorder's symptoms, and to design targeted treatments. “It’s a strategy that can be applied in multiple ways, and I think can be useful right now,” says Jeanne Lawrence, a cell biologist at the University of Massachusetts Medical School in Worcester, and the lead author of the study. Lawrence and...
  • Miniature human liver grown in mice

    07/04/2013 1:26:41 PM PDT · by neverdem · 6 replies
    Nature News ^ | 03 July 2013 | Monya Baker
    Cells self-organize and grow into functional organs after transplantation. Transplanting tiny 'liver buds' constructed from human stem cells restores liver function in mice, researchers have found. Although preliminary, the results offer a potential path towards developing treatments for the thousands of patients awaiting liver transplants every year. The liver buds, approximately 4 mm across, staved off death in mice with liver failure, the researchers report this week in Nature1. The transplanted structures also took on a range of liver functions — secreting liver-specific proteins and producing human-specific metabolites. But perhaps most notably, these buds quickly hooked up with nearby blood...
  • Stem-Cell Trial a Victory for Science, and for Life

    06/28/2013 3:27:01 PM PDT · by neverdem · 8 replies
    National Review Online ^ | June 28, 2013 | Will Allen
    The Japanese Health Ministry has approved the first human clinical trial involving induced pluripotent stem cells (know as iPSCs), which are taken from a patient’s epithelial tissue for use elsewhere in his body. The trial will remove skin cells from six adults who suffer from age-related macular degeneration; scientists at the RIKEN Center for Developmental Biology in Kobe will then attempt to develop the cells into retinal tissue for transplant back to each patient’s eyes. The outcome of the treatment is by no means assured; the trial will take four years to complete, and as the National Institutes of Health...
  • Stem Cell Biology

    03/15/2013 12:37:53 PM PDT · by neverdem · 1 replies
    Cell Research ^ | January 2013 | NA
    The January special issue of Cell Research on Stem Cell Biology brings together the latest reviews and articles in the field. Together with the accompanying web focus, Cell Research delves into our current understanding and investigates recent advances in various aspects of stem cell biology, cell reprogramming, and their relevance to diseases.Special Issue on Stem Cell Biology
  • First Human Induced Pluripotent Stem Cell Trial

    02/15/2013 12:12:07 AM PST · by neverdem
    National Review Online ^ | February 14, 2013 | Wesley J. Smith
    At present, there are three small human safety embryonic stem cell studies. All deal with macular degeneration-type conditions. And now, a human trial looks to soon get underway in Japan using induced pluripotent stem cells, that is, stem cells made from a patient’s own skin or other tissues. From the Nature News story: Having already received IRB approval at her home institution, Takahashi can now move towards the final step before patient recruitment: getting health ministry approval.  She’s expected receive that in time for starting the trials during this fiscal year, ending March 2014. The trial will enroll six patients...
  • Japan researchers grow kidney tissue from stem cells

    01/23/2013 3:37:28 PM PST · by neverdem · 6 replies
    AFP via Google ^ | 1/23/2013 | NA
    16 hours ago TOKYO — Researchers in Japan said Wednesday they have succeeded in growing human kidney tissue from stem cells for the first time in a potential breakthrough for millions with damaged organs who are dependent on dialysis. Kidneys have a complex structure that is not easily repaired once damaged, but the latest findings put scientists on the road to helping a diseased or distressed organ fix itself. Kenji Osafune of Kyoto University said his team had managed to take stem cells -- the "blank slates" capable of being programmed to become any kind of cell in the body...

    12/17/2012 10:49:43 PM PST · by neverdem · 4 replies
    Singularity Hub ^ | 12/17/12 | Peter Murray
    Stem cells derived from patients with disorders, such as these Parkinson’s cells, could foster drug screening to find treatments and also provide researchers a valuable tool to study disease. Europe certainly believes in the promise of stem cells.A joint public-private collaboration between the European Union and Europe’s pharmaceutical industry, called the StemBANCC project, will spend nearly 50 million euros to create 1,500 pluripotent stem cell lines. But the initiative’s goal isn’t to find a stem cell-based cure for diabetes or Alzheimer’s disease. They hope instead that their stem cell lines will prove to be faster and more effective drug screens...
  • Stem-Cell Cures Without the Controversy

    12/08/2012 9:49:01 PM PST · by neverdem · 3 replies
    Wall Street Journal ^ | December 7, 2012 | Matt Ridley
    The chief medical ambition of those who study stem cells has always been that the cells would be used to repair and regenerate damaged tissue. That's still a long way off, despite rapid progress exemplified by the presentation of the Nobel Prize next week to Shinya Yamanaka of Kyoto University for a key stem-cell breakthrough. But there's another, less well known application of stem cells that is already delivering results: disease modeling. Dr. Yamanaka used a retrovirus to insert four genes into a mouse cell to return it to a "pluripotent" state—capable of turning into almost any kind of cell....
  • Reprogrammed Cells Earn Nobel Honor

    10/08/2012 7:27:15 PM PDT · by neverdem · 8 replies
    ScienceNOW ^ | 8 October 2012 | Gretchen Vogel
    The discovery that cellular development is not a one-way street has earned this year's Nobel Prize in physiology or medicine. John B. Gurdon, a developmental biologist at the Wellcome Trust/Cancer Research UK Gurdon Institute at the University of Cambridge in the United Kingdom, and Shinya Yamanaka, a stem cell researcher at Kyoto University in Japan and the Gladstone Institute at the University of California, San Francisco, have won the prize for their discovery that mature cells can be reprogrammed to resemble the versatile cells of a very early embryo. These so-called pluripotent cells have the ability to become any of...
  • Sperm and Eggs Created in Dish Produce Mouse Pups

    10/05/2012 11:48:59 AM PDT · by neverdem · 20 replies
    ScienceNOW ^ | 4 October 2012 | Dennis Normile
    Enlarge Image Who's your mommy? These adult mice grew from oocytes, or immature eggs, derived in vitro from induced pluripotent stem cells. Credit: Mitinori Saitou and Katsuhiko Hayashi Want baby mice? Grab a petri dish. After producing normal mouse pups last year using sperm derived from stem cells, a Kyoto University team of researchers has now accomplished the same feat using eggs created the same way. The study may eventually lead to new ways of helping infertile couples conceive. "This is a significant achievement that I believe will have a sustained and long-lasting impact on the field of reproductive...
  • Whitehead scientists bring new efficiency to stem cell reprogramming

    09/19/2012 3:02:32 PM PDT · by neverdem · 6 replies
    Biology News Net ^ | September 13, 2012 | NA
    In this image of mouse embryonic fibroblasts undergoing reprogramming, each colored dot represents messenger RNA associated with a specific gene that is active in cells being reprogrammed. Red dots represent... Several years ago, biologists discovered that regular body cells can be reprogrammed into pluripotent stem cells — cells with the ability to become any other type of cell. Such cells hold great promise for treating many human diseases. These induced pluripotent stem cells (iPSCs) are usually created by genetically modifying cells to overexpress four genes that make them revert to an immature, embryonic state. However, the procedure works in only...
  • Stem-cell pioneer banks on future therapies - Japanese researcher plans cache of induced stem...

    08/10/2012 12:29:09 AM PDT · by neverdem · 3 replies
    Nature News ^ | 07 August 2012 | David Cyranoski
    Japanese researcher plans cache of induced stem cells to supply clinical trials. Progress toward stem-cell therapies has been frustratingly slow, delayed by research challenges, ethical and legal barriers and corporate jitters. Now, stem-cell pioneer Shinya Yamanaka of Kyoto University in Japan plans to jump-start the field by building up a bank of stem cells for therapeutic use. The bank would store dozens of lines of induced pluripotent stem (iPS) cells, putting Japan in an unfamiliar position: at the forefront of efforts to introduce a pioneering biomedical technology. A long-held dream of Yamanaka’s, the iPS Cell Stock project received a boost...
  • New method generates cardiac muscle patches from stem cells

    06/25/2012 11:17:30 PM PDT · by neverdem · 11 replies
    Biology News Net ^ | June 20, 2012 | NA
    A cutting-edge method developed at the University of Michigan Center for Arrhythmia Research successfully uses stem cells to create heart cells capable of mimicking the heart's crucial squeezing action. The cells displayed activity similar to most people's resting heart rate. At 60 beats per minute, the rhythmic electrical impulse transmission of the engineered cells in the U-M study is 10 times faster than in most other reported stem cell studies. An image of the electrically stimulated cardiac cells is displayed on the cover of the current issue of Circulation Research, a publication of the American Heart Association. For those suffering...
  • Stem Cells Move Into Prime Time

    06/18/2012 6:49:31 PM PDT · by neverdem · 21 replies
    ScienceNOW ^ | 18 June 2012 | Dennis Normile
    Enlarge Image Ring of protection. In experiments, myelin produced by injected human neural stem cells (green) formed protective sleeves around the nerve fibers in mouse brains (red). Credit: RIKEN CDB; StemCells Inc. YOKOHAMA, JAPAN—For more than a decade, stem cell therapies have been touted as offering hope for those suffering from genetic and degenerative diseases. The promise took another step toward reality last week with announcements here at the annual meeting of the International Society for Stem Cell Research (ISSCR) that two groups are moving forward with human clinical research, one focusing on a rare genetic neurological disease and...
  • New Stem Cell Technique Promises Abundance of Key Heart Cells

    05/29/2012 4:35:53 PM PDT · by neverdem · 5 replies
    ScienceDaily ^ | May 28, 2012 | NA
    Cardiomyocytes, the workhorse cells that make up the beating heart, can now be made cheaply and abundantly in the laboratory. Writing this week (May 28, 2012) in the Proceedings of the National Academy of Sciences, a team of Wisconsin scientists describes a way to transform human stem cells -- both embryonic and induced pluripotent stem cells -- into the critical heart muscle cells by simple manipulation of one key developmental pathway. The technique promises a uniform, inexpensive and far more efficient alternative to the complex bath of serum or growth factors now used to nudge blank slate stem cells to...
  • Improved Adult-Derived Human Stem Cells Have Fewer Genetic Changes Than Expected

    05/01/2012 1:29:10 AM PDT · by neverdem · 1 replies
    ScienceDaily ^ | Apr. 30, 2012 | NA
    A team of researchers from Johns Hopkins University and the National Human Genome Research Institute has evaluated the whole genomic sequence of stem cells derived from human bone marrow cells -- so-called induced pluripotent stem (iPS) cells -- and found that relatively few genetic changes occur during stem cell conversion by an improved method. The findings, reported in the March issue of Cell Stem Cell, the official journal of the International Society for Stem Cell Research (ISSCR), will be presented at the annual ISSCR meeting in June. "Our results show that human iPS cells accrue genetic changes at about the...
  • Spell-Checked Stem Cells Show Promise Against Liver Disease

    10/13/2011 6:56:01 PM PDT · by neverdem · 14 replies
    ScienceNOW ^ | 12 October 2011 | Jocelyn Kaiser
    Enlarge Image Gene fix. Red cells in this slice of mouse liver are making a human protein called A1At. Credit: K. YUSA ET AL., NATURE (ADVANCED ONLINE EDITION) ©2011 MACMILLAN PUBLISHERS LTD. Researchers have taken a step toward showing how stem cells might one day be used to help patients born with a deadly liver disease. The researchers corrected a DNA spelling error in patient skin cells that had been converted into so-called induced pluripotent stem (iPS) cells, then coaxed the cells to form liver cells that seemed to function normally in mice. The approach is still a long...
  • Flaw in induced-stem-cell model - Adult cells do not fully convert to embryonic-like state.

    02/03/2011 3:09:28 PM PST · by neverdem · 19 replies
    Nature News ^ | 2 February 2011 | Elie Dolgin
    Medical researchers' hopes of replacing politically fraught embryonic stem (ES) cells with stem cells derived from adult tissues have suffered a setback. Induced pluripotent stem (iPS) cells, created by turning back the developmental clock on adult tissues, and ES cells display similar gene-expression patterns, and both can produce any of the various tissues in the human body. But patterns of epigenetic changes — alterations that affect gene expression without changing the DNA sequence — tell a different story about iPS cells, a team led by Joseph Ecker, a molecular geneticist at the Salk Institute in La Jolla, California, reports online...
  • Some stem cells hold on to their past, researchers say

    02/03/2011 9:38:37 AM PST · by Gondring · 14 replies
    Los Angeles Times ^ | February 3, 2011 | Eryn Brown, Los Angeles Times
    Stem cells made from mature cells and rewound to an embryonic-like state retain a distinct "memory" of their past that might limit their potential for therapeutic use, scientists reported Wednesday in the journal Nature. [...] They looked at 1.2 billion places in each genome where such chemical markers [epigenomes] exist. The analysis was unusually rigorous — and therefore unusually revealing, Ecker said. Earlier studies examined representative regions in the genome, rather than the whole thing. [...] For the most part, the contents of Ecker's metaphorical rooms looked alike. But when they zoomed in, inconsistencies emerged. In a side-by-side comparison of...
  • A Better Way to Reprogram Cells

    10/01/2010 6:00:36 PM PDT · by neverdem · 6 replies
    ScienceNOW ^ | 30 September 2010 | Gretchen Vogel
    Enlarge Image New fate. Applying synthetic RNA for a muscle master-control gene turns embryonic cells into muscle cells. Credit: Warren et al., Cell Stem Cell, Advance Online Publication (2010) Four years ago, scientists took a major step toward overcoming the biggest ethical hurdle in stem cell research. Instead of using cells derived from embryos, researchers found a way to make adult cells behave as though they were embryonic. Simply inserting extra copies of four genes into these cells gave them the power to develop into almost any cell type in the body—a potential boon for studying and ultimately treating...
  • Extracted Teeth Could Stock Stem Cell Banks

    06/27/2010 1:43:53 PM PDT · by neverdem · 5 replies
    Discovery News ^ | Jun 25, 2010 | Irene Klotz
    Japanese researchers coax soft, living tissue from inside extracted wisdom teeth into forming stem cells. Scientists have found a new and relatively accessible supply line for stem cells that can grow into any type of cell in the human body -- extracted teeth. Like cells from embryos, the soft living tissue from inside teeth can be induced to become what are known as pluripotent stem cells, which have the potential to form several different cell types. Unlike embryonic cells, which are extracted from days-old human embryos, generating stem cells from dental pulp is a relatively non-invasive and non-controversial process. Studies...
  • Gene flaw found in induced stem cells

    03/31/2010 9:24:28 PM PDT · by neverdem · 3 replies · 296+ views
    Nature News ^ | 31 March 2010 | Elie Dolgin
    Key difference between reprogrammed adult mouse cells and embryonic stem cells discovered.Stem-cell researchers have puzzled over why reprogrammed cells taken from adult tissues are often slower to divide and much less robust than their embryo-derived counterparts.Now, a team has discovered the key genetic difference between embryonic and adult-derived stem cells in mice. If confirmed in humans, the finding could help clinicians to select only the heartiest stem cells for therapeutic applications and disease modelling.Induced pluripotent stem (iPS) cells are created by reprogramming adult cells, and outwardly seem indistinguishable from embryonic stem (ES) cells. Both cell types are pluripotent — they...
  • Stem cell experiment reverses aging in rare disease

    02/17/2010 1:05:18 PM PST · by decimon · 10 replies · 366+ views
    Reuters ^ | Feb 17, 2010 | Maggie Fox
    WASHINGTON (Reuters) – In a surprise result that can help in the understanding of both aging and cancer, researchers working with an engineered type of stem cell said they reversed the aging process in a rare genetic disease. The team at Children's Hospital Boston and the Harvard Stem Cell Institute were working with a new type of cell called induced pluripotent stem cells or iPS cells, which closely resemble embryonic stem cells but are made from ordinary skin cells. In this case, they wanted to study a rare, inherited premature aging disorder called dyskeratosis congenita. The blood marrow disorder resembles...
  • Method of the Year 2009

    12/31/2009 7:36:04 PM PST · by neverdem · 3 replies · 297+ views
    Nature Methods ^ | Dec. 2009 | NA
    Nature Methods' Method of the Year 2009 goes to induced pluripotency for its potential for biological discovery. This series of articles—and the related video—showcase how induced pluripotency is coming into its own in 2009 as a tool for discovery in both basic and disease biology and explore the incredible impact this area promises to have in biological research. The Methods to Watch feature provides a glimpse of future Methods of the Year and the Reader's Choice shows methods nominated by readers and editors, and the votes that they received...
  • Primer: induced pluripotency

    12/31/2009 7:25:21 PM PST · by neverdem · 5 replies · 390+ views
    Nature Methods ^ | 19 December 2009 | Natalie de Souza
    Abstract A brief overview of methods for reprogramming to induced pluripotency and of the properties of induced pluripotent stem cells. Introduction What is induced pluripotency? Pluripotency—the ability to make all cell types of the body—is a property possessed by a few cells in the early mammalian embryo, those belonging to the blastocyst inner cell mass. Embryonic stem (ES) cells are derived by in vitro culture of the inner cell mass and are also pluripotent. As the embryo develops, its cells become progressively more specialized and pluripotency is lost, although somatic tissues retain what are called multipotent cells (or adult stem...
  • IPSCs: One cell to rule them all?

    12/31/2009 5:12:15 PM PST · by neverdem · 363+ views
    Nature Methods ^ | 2010 | Michael Eisenstein
    Abstract Rapid progress with induced pluripotent stem cells is bringing scientists closer to understanding their strengths and weaknesses as embryonic stem cell stand-ins. Introduction In 2006, with formidable legal and technical obstacles keeping the promise of embryonic stem cells (ESCs) in check, Shinya Yamanaka's announcement was truly a scientific 'shot heard around the world'. He and his team at Kyoto University had reprogrammed adult mouse fibroblasts into so-called induced pluripotent stem cells (iPSCs)1, opening the stem cell field to legions of eager scientists and offering the promise of unprecedented capabilities for targeted disease research using stem cells derived directly from...
  • iPS cells: potent stuff

    12/31/2009 1:00:16 PM PST · by neverdem · 1 replies · 316+ views
    Nature Methods ^ | 21 December 2009 | Monya Baker
    Monya Baker is Technology Editor at Nature and Nature Methods Correspondence to: Monya Baker1 e-mail: Abstract Now that the generation of induced pluripotent stem cells is becoming routine, researchers can get on to the more exciting prospect of using the cells to make discoveries in disease and basic biology. Monya Baker reports. Introduction As Shinya Yamanaka finished the experiments that would win him the 2009 Lasker prize, a stem-cell fraud was prominent in his thoughts. In 2005, Woo Suk Hwang had rocketed to star status for reportedly developing a technique to generate human embryonic stem (ES) cells genetically matched...
  • Citrus surprise: Vitamin C boosts the reprogramming of adult cells into stem cells

    12/24/2009 10:02:06 AM PST · by decimon · 6 replies · 901+ views
    Cell Press ^ | Dec 4, 2009 | Unknown
    Famous for its antioxidant properties and role in tissue repair, vitamin C is touted as beneficial for illnesses ranging from the common cold to cancer and perhaps even for slowing the aging process. Now, a study published online on December 24th by Cell Press in the journal Cell Stem Cell uncovers an unexpected new role for this natural compound: facilitating the generation of embryonic-like stem cells from adult cells. Over the past few years, we have learned that adult cells can be reprogrammed into cells with characteristics similar to embryonic stem cells by turning on a select set of genes....
  • Al Gore on board for $20M (Adult) stem cell venture

    12/16/2009 10:53:12 AM PST · by Coleus · 17 replies · 477+ views
    USA Today | April 14, 2009 | Dan Vergano
    Al Gore on board for $20M stem cell venture
  • Faster route to stem-like cells - All adult cells can be reprogrammed, researchers claim.

    11/08/2009 9:44:40 PM PST · by neverdem · 5 replies · 632+ views
    Nature News ^ | 8 November 2009 | Alison Abbott
    Induced pluripotent stem cells could be a boon for regenerative medicine.REUTERS/Junying Yu/University of Wisconsin-Madison Given the right conditions, any adult cell can be coaxed into becoming stem-cell like, according to a team of researchers based in the United States. The team, led by Rudolf Jaenisch of the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, were also able to speed up the process, cutting the time required for cells to become stem-cell like by around half. The results are good news for those battling to work out the complex biology of these cells, know as induced pluripotent stem (iPS) cells...
  • In search of true stem-like cells - Live-cell fluorescence imaging identifies bona fide...

    10/11/2009 6:35:19 PM PDT · by neverdem · 3 replies · 674+ views
    Nature News ^ | 11 October 2009 | NA
    Live-cell fluorescence imaging identifies bona fide reprogrammed cells.Fluorescence imaging could help resolve whether iPS cells have been properly programmed.Alamy The next tools for reprogramming cells to an embryonic-like state might just be a camera and a set of fluorescently tagged antibodies. Researchers imaged more than a million human cells in vitro as they changed from skin tissue cells, known as fibroblasts, into colonies of induced pluripotent stem (iPS) cells. As expected, many similar-looking colonies appeared, but only very few consisted of fully reprogrammed iPS cells. After assessing which were which, researchers led by Thorsten Schlaeger and George Daley of the...
  • Flab and freckles could advance stem cell research

    09/07/2009 2:22:06 PM PDT · by neverdem · 7 replies · 600+ views
    Nature News ^ | 7 September 2009 | Elie Dolgin
    Alternative tissues shown to yield reprogrammed cells aplenty. Fat cells are more easily turned into iPS cells than fibroblasts.Punchstock Fat cells and pigment-producing skin cells can be reprogrammed into stem cells much faster and more efficiently than the skin cells that are usually used — suggesting large bellies and little black moles could provide much-needed material for deriving patient-specific stem cells."More than one type of adult somatic cell can serve as a target for reprogramming to a pluripotent state," says William Lowry, a stem-cell biologist at the University of California, Los Angeles, who was not involved in the research. "You...
  • Immortality improves cell reprogramming - Knocking out genes with a role in cancer prevention...

    08/13/2009 11:36:46 AM PDT · by neverdem · 5 replies · 449+ views
    Nature News ^ | 9 August 2009 | Elie Dolgin
    Knocking out genes with a role in cancer prevention helps produce stem cells.Switching off the p53 pathway helped researchers to make stem-like cells.Wikimedia Commons Specialized adult cells made 'immortal' through the blockade of an antitumour pathway can be turned into stem-like cells quickly and efficiently.The findings — which should make it easier to generate patient-specific cells from any tissue type, including certain diseased cells that have proved difficult to transform — suggest that cellular reprogramming and cancer formation are inextricably linked.Since 2006, when Shinya Yamanaka of Japan's Kyoto University first created induced pluripotent stem (iPS) cells1 — which can develop...
  • Critics Slam N.Y. Plan to Pay Women to Donate Eggs for Stem Cell Research

    07/31/2009 12:34:24 AM PDT · by neverdem · 17 replies · 493+ views ^ | July 30, 2009 | Joshua Rhett Miller
    The decision to offer New York women up to $10,000 to donate their eggs for stem cell research, payable by taxpayers, is "incredibly irresponsible and immoral," critics told New York's decision to offer women in the state up to $10,000 to donate their eggs for stem cell research, payable by taxpayers, is "incredibly irresponsible and immoral," critics told Wendy Wright, president of Concerned Women for America, said the move -- the first of its kind nationwide -- treats women as "commodities, almost like cows" and could lead to cash-strapped women in other states to partake in similar programs....
  • Mice made from induced stem cells - Technical feat shows that the different route to stem...

    07/25/2009 5:44:16 PM PDT · by neverdem · 2 replies · 524+ views
    Nature News ^ | 23 July 2009 | David Cyranoski
    Technical feat shows that the different route to stem cells can indeed make a full mammal body. Two teams of Chinese researchers have created live mice from induced pluripotent stem (iPS) cells, answering a lingering question about the developmental potential of the cells. Since Shinya Yamanaka of Kyoto University in Japan created the first iPS cells1 in 2006, researchers have wondered whether they could generate an entire mammalian body from iPS cells, as they have from true embryonic stem cells. Experiments reported online this week in Nature 2 and in Cell Stem Cell 3 suggest that, at least for mice,...
  • Embryonic Stem Cells 'Obsolete'

    07/16/2009 6:47:14 PM PDT · by Kaslin · 8 replies · 580+ views
    IBD Editorials ^ | July 16, 2009 | INVESTORS BUSINESS DAILY Staff
    Bioethics: The former director of the National Institutes of Health, once an enthusiast for embryonic stem cells, now says their future has "dimmed." So why is the administration bailing out research into such therapies while troubled states like California have committed billions?Aside from creating or saving a few research jobs, the administration's decision to federally fund embryonic stem cell research is, as we've noted, a bailout of bad science. It throws money at an avenue of research that time and adult stem cell progress have passed by. Applauding the administration's move was Sen. Arlen Specter, D-Pa., who echoed the claims...
  • Induced Pluripotent Stem Cells Repair Heart

    07/21/2009 2:28:31 PM PDT · by neverdem · 4 replies · 668+ views
    In a proof-of-concept study, Mayo Clinic investigators have demonstrated that induced pluripotent stem (iPS) cells can be used to treat heart disease. iPS cells are stem cells converted from adult cells. In this study, the researchers reprogrammed ordinary fibroblasts, cells that contribute to scars such as those resulting from a heart attack, converting them into stem cells that fix heart damage caused by infarction. The findings appear in the current online issue of the journal Circulation. "This study establishes the real potential for using iPS cells in cardiac treatment," says Timothy Nelson, M.D., Ph.D., first author on the Mayo Clinic...
  • The Grail Searchers (science shows that an embryo is a human being)

    07/20/2009 8:29:02 AM PDT · by SeekAndFind · 5 replies · 635+ views
    National Review ^ | 7/20/2009 | Maureen Condic, Patrick Lee, and Robert P. George
    “The development of a human being begins with fertilization, a process by which the spermatozoon from the male and the oocyte from the female unite to give rise to a new organism, the zygote.” — Langman’s Medical Embryology, 7th edition, 1995 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------- For people who advocate the killing of embryonic human beings in the cause of biomedical research, the Holy Grail is an argument that would definitively establish that the human embryo, at least early in its development, is not a living human organism and therefore not a human being at all. The problem for these advocates is that all...
  • Do Skin Cells Have Souls? The debate over stem cells is back, and better than ever.

    07/08/2009 7:40:47 PM PDT · by neverdem · 33 replies · 1,686+ views
    Reason ^ | July 7, 2009 | Ronald Bailey
    Less than two years ago, it looked like the ethical debate over human embryonic stem cells might be coming to an end. In November 2007, two research groups, one at the University of Wisconsin-Madison and another at Kyoto University in Japan, announced that they had succeeded in directly reprogramming human skin cells into stem cells. Earlier this year, Canadian and British researchers reported even better news. They have developed a new way to create such cells without using viruses, which pose a risk of producing tumors by damaging the transformed cells' genes. Yesterday, as many as 700 new stem cell...
  • The cell that might save sight - Why stem-cell therapy could start with the eyes

    06/19/2009 12:48:32 PM PDT · by neverdem · 16 replies · 936+ views
    Nature Reports Stem Cells ^ | 11 June 2009 | Amber Dance
    Look to the retina as a likely site for the first success in stem-cell therapy. "The eye is the best place to test proof-of-concept for stem cell-based therapies," says Martin Friedlander of the Scripps Research Institute in La Jolla, California. Friedlander is co-founder of EyeCyte, also in La Jolla, whose investors include industry heavyweight Pfizer. Several laboratories are exploring stem-cell-derived transplants to delay or prevent blindness, and Pfizer recently put up funds for a project nearing human trials at University College London (UCL). Why the eye appeal? As organs go, it is easily accessible, somewhat protected from the immune system's...
  • Turning wood into bone: peg-leg science

    06/17/2009 7:36:57 AM PDT · by neverdem · 10 replies · 558+ views
    Royal Society of Chemistry ^ | 16 June 2009 | NA
    Pirates can now trade in their peg-legs for real legs as scientists transform wood into bone.In a Royal Society of Chemistry journal Italian chemists show that ordinary wood can be turned into bone suitable for repairing damaged limbs.It brings a whole new meaning to the term "tree surgery".The microstructure of the wood is the perfect natural template for making bone as it allows growth of blood vessels and tissues, Anna Tampieri and colleagues report in the Journal of Materials Chemistry.By treating wood with a fairly simple set of chemical processes, the natural structure of the wood is retained.The wood is...
  • Embryonic-like Cells Advance Toward Disease Treatment

    06/02/2009 9:24:12 PM PDT · by neverdem · 8 replies · 576+ views
    ScienceNOW Daily News ^ | 1 June 2009 | Constance Holden
    Enlarge ImageOn track. Colonies of genetically corrected cells taken from Fanconi anemia patients show red and yellow, markers associated with pluripotency. Credit: Juan Carlos Izpisúa Belmonte Two papers published this week appear to bring closer the day when embryonic-like stem cells can be used to treat human diseases. One study describes what scientists say is the safest method yet to produce these cells. The other reports success in using the cells to begin correcting a rare genetic disorder known as Fanconi anemia. Induced pluripotent stem (iPS) cells were first reported in 2006 by Shinya Yamanaka, a researcher at Kyoto...
  • Stem-Cell Breakthrough May Silence Critics

    04/23/2009 4:06:15 PM PDT · by nickcarraway · 40 replies · 1,876+ views
    NBC Bay Area ^ | 4/23/09 | Eric Page
    Researchers have announced a breakthrough that could end the ethical debate surrounding stem-cell research. The groundbreaking technique would allow the conversion of adult cells into an embryonic-like state. Researchers have been competing in recent years to reach just such a discovery, which would allow them to perform their work without using the controversial embryonic stem cell lines. Scientists at the the Scripps Research Institute in San Diego believe the key to their success is converting the cells by using recombinant proteins, which eliminates subsequent genetic alterations that typically occur during later stages. "Instead of inserting the four genes into the...
  • Stem Cells: Dr. Oz on 'Oprah'

    04/06/2009 8:45:52 PM PDT · by Coleus · 28 replies · 3,771+ views
    ncr ^ | 04.04.09 | Tom Hoopes
    Here’s Josh Brahm explaining this “Oprah” spot, in which Dr. Oz comes out against embryonic stem-cell research on scientific grounds (Warning: In it he handles, pokes and slices a real human brain).  Catholics remember sadly that Michael J. Fox was a huge proponent of clone-and-kill stem-cell research. How ironic that President Obama, who claims to want to “follow science” is funding precisely the kind of research that the medical community is abandoning. See Josh Brahm’s essay “9 Things the Media Messed Up About the Obama Stem Cell Story.”On the “Oprah” show, Dr. Mehmet Oz handles the brain of a 50-year-old...