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Unsupervised exposures of infants and young children to melatonin have increased substantially in recent years, landing thousands of children in the emergency room. The number of kids aged 5 and younger who went to an emergency room for unsupervised melatonin ingestion increased 420 percent from 2009 to 2020, according to new data from the Centers for Disease Control and Prevention (CDC). More recently, melatonin was implicated in approximately 11,000 emergency department visits among infants and young children between 2019–2022. Those ER visits highlight the continued need to educate parents and other caregivers about the importance of keeping all medications and...

The glymphatic system is the brain's self-cleaning mechanism. It wasn't discovered until 2012. The glymphatic system is tied to the circadian system and sleep architecture, and both are implicated in the pathophysiology of concussions. I'll explain the glymphatic system's nature, how its dysfunction contributes to concussion pathology, and the crucial role of circadian therapy in mitigating this impact. The glymphatic system was nicknamed "the garbage truck of the brain" by its discoverer. Its fundamental role is to remove waste products from the brain. Approximately 80–90% of glymphatic clearance occurs during "deep sleep." As sleep transitions from deep sleep into the...

An article shows that melatonin, despite its antioxidant effects and role in regulating sleep cycles, can worsen inflammation of the intestine and impair the action of gut microbiota. Melatonin is popularly known as the "sleep hormone" and is often taken as a so-called food supplement without a doctor's prescription by people with sleep problems. "It's generally thought to be harmless. However, our study shows that the ingestion of melatonin supplement can have adverse effects on health," said Cristina Ribeiro de Barros Cardoso. Melatonin can act as an antioxidant and improve several physiological or pathological conditions. "We started out in this...

Medical sleep treatment may reduce self-harm in young people with anxiety and depression, an observational study suggests. The risk of self-harm increased in the months preceding melatonin prescription and decreased thereafter, especially in girls. Melatonin is a hormone that controls the sleep-wake cycle and is the most commonly prescribed drug for sleep disturbances in children and adolescents in Sweden. Melatonin use has dramatically increased in recent years. The study identified over 25,500 children and teenagers between the ages of 6 and 18 who were prescribed melatonin in Sweden. Over 87 percent had at least one psychiatric disorder, mainly attention-deficit hyperactivity...

A new study shows that using a weighted blanket at bedtime increases melatonin in young adults. This hormone increases in response to darkness, and some evidence suggests that it promotes sleep. Previous research has shown that weighted blankets may ease insomnia in humans. However, the underlying mechanisms are not fully understood. Hence, researchers from Uppsala University in Sweden experimented with 26 young men and women to examine if the bedtime use of a weighted blanket increases the production of sleep-promoting and anti-stress hormones like melatonin and oxytocin. In addition, they investigated whether the bedtime use of a weighted blanket (12%...

In a small study of healthy adults aged 55 and older, 5 mg of melatonin increased total sleep time compared to a placebo. Researchers conducted the study in 24 healthy, older adults to evaluate whether a high-dose or a low-dose melatonin supplement could improve sleep. The team found that the higher dose had a significant impact, increasing total sleep time compared to placebo by more than 15 minutes for nighttime sleep and by half an hour for daytime sleep. The body naturally produces melatonin, which helps regulate a person's sleep-wake cycle with night and day. Melatonin levels peak at night....

The American Heart Association has issued its yearly reminder that incidents of heart disease and stroke go up at daylight saving time — a biological "clock shock" thus far unexplained. Changing the clock changes up our body's production of hormones, including melatonin, the night-time hormone that affects sleep; cortisol, the stress hormone; and serotonin, the "feel-good" hormone that helps keep depression and anxiety at bay. It's especially important over the next few days to try to go to bed and wake up at the same time every day, even, as difficult as it is to hear, on weekends. Bhat says...

Asthma sufferers generally find their condition gets worse at night. Now, a research group may understand why. Melatonin, a sleep hormone that is sometimes prescribed to treat insomnia, exasperates the constriction of the bronchus—the pathway that moves air to and from the lungs. Patients with asthma often experience a worsening of asthmatic symptoms at night in so-called "nocturnal asthma." According to reports, more than 50 percent of asthma deaths occur at night, exposing a link between nocturnal asthma symptoms and asthma deaths. Although some have proposed several triggers that explain the pathogenesis of nocturnal asthma, the precise mechanisms regulating this...

Two key studies have identified the role that melatonin plays in reducing the risk of a positive test for COVID-19 and lowering the incidence of severe symptoms.That new finding adds to a list of benefits linked to melatonin since it was first discovered in 1958 by Dr. Aaron Lerner, a dermatologist who was able to isolate it from the pineal gland in a cow.Scientists began studying melatonin in the 1980s, and by the 1990s, it received more attention. Research data showed that melatonin influences a number of bodily processes, including calcium-dependent metabolism, immune modulation, and tumor growth—which it can restrain.Although...

Melatonin is a natural hormone produced by the brain to promote healthy sleep and regulate the body’s internal clock. It can also be taken in the form of a dietary supplement, and studies have shown melatonin to be effective in improving sleep and treating headaches, anxiety and other health conditions. Most recently, though, researchers have focused their attention on the effect melatonin might have on COVID-19 and the vaccines created to prevent it. According to a Cleveland Clinic study, melatonin may help prevent COVID-19 or aid in the treatment of COVID-19 due to its antioxidant and anti-inflammatory effects. Researchers found...

Abstract A recent retrospective study has provided evidence that COVID-19 infection may be notably less common in those using supplemental melatonin. It is suggested that this phenomenon may reflect the fact that, via induction of silent information regulator 1 (Sirt1), melatonin can upregulate K63 polyubiquitination of the mitochondrial antiviral-signalling protein, thereby boosting virally mediated induction of type 1 interferons. Moreover, Sirt1 may enhance the antiviral efficacy of type 1 interferons by preventing hyperacetylation of high mobility group box 1 (HMGB1), enabling its retention in the nucleus, where it promotes transcription of interferon-inducible genes. This nuclear retention of HMGB1 may also...

Researchers at Tokyo Medical and Dental University (TMDU) in Japan show that melatonin and its metabolites promote the formation of long-term memories in mice and protect against cognitive decline. Researchers at Tokyo Medical and Dental University (TMDU) showed that melatonin’s metabolite AMK can enhance the formation of long-term memories in mice. Memory of objects were tested after treatment with melatonin or two of its metabolites. Older mice that normally performed poorly on the memory task showed improvements as dosage increased. The metabolite AMK was found to be the most important as melatonin failed to improve memory if it was blocked...

Melatonin, a dietary supplement often used by insomnia sufferers, could be used to possibly help prevent or treat COVID-19, according to researchers at the Cleveland Clinic. The hormone — which regulates the sleep-wake cycle — was associated with an almost 30 percent reduced likelihood of contracting the disease, the scientists said in research published in the journal PLOS Biology, KIRO 7 reported. Additional studies are required about the over-the-counter supplement, the researchers said. “It is very important to note these findings do not suggest people should start to take melatonin without consulting their physician,” lead researcher Feixiong Cheng of the...

New findings published in PLOS Biology use “big data” approach. Results from a new Cleveland Clinic-led study suggest that melatonin, a hormone that regulates the sleep-wake cycle and is commonly used as an over-the-counter sleep aid, may be a viable treatment option for COVID-19. As COVID-19 continues to spread throughout the world, particularly with cases rising during what some have termed the “fall surge,” repurposing drugs already approved by the U.S. Food and Drug Administration for new therapeutic purposes continues to be the most efficient and cost-effective approach to treat or prevent the disease. According to the findings published today...

4 min video posted on his twitter looks and sounds grrat

An Oregon woman accused of drugging kids at her day care so she could go to the tanning bed and work out, was sentenced to to 21 years and four months in prison on Friday. January Neatherlin was sentenced Friday after pleading guilty in February to 11 counts of first-degree criminal mistreatment and one count of third-degree assault,The Oregonian reported. The 32-year-old was arrested last year after police found seven young children unattended at her unlicensed day care Little Giggles, KTVZ-TV reported. According to authorities, Neatherlin drugged the children with sleeping-aid melatonin before leaving the facility to tan and work...

Three teachers have been charged after police said they distributed gummy bears with melatonin to kids without parental consent at a Des Plaines day care center last Friday. Officers arrived Friday afternoon to the Kiddie Junction Daycare Center at 1619 E. Oakton Street after a report of a suspicious incident. Police said that gummy bears with melatonin were given to a class of 2 year olds to get them to calm down before nap time without parental authorization. Police said that three teachers admitted distributing melatonin to the children and did not think it was inappropriate as they were an...

AND NOW . . . amidst billowing clouds of fragrant, aromatic first- and second-hand premium cigar smoke. . . it is time for . . . that harmless, lovable little fuzz ball, the highly-trained broadcast specialist, having more fun than a human being should be allowed to have, from behind the golden EIB microphone, firmly ensconced in the prestigious Attila-the-Hun chair at the Limbaugh Institute of Advanced Conservative Studies, serving humanity simply by showing up, and he’s not retiring until every American agrees with him, do NOT doubt him, with shrieks of joy at the mere mention of his name...

Public health advocates and some mayors are sounding the alarm over Lazy Cakes, a brownie adorned with a lackadaisical cartoon character and laced with a powerful sleep aid that has sold millions nationwide. “Children are attracted to brownies,” said Dr. Caroline Apovian, director of the Nutrition and Weight Management Center at Boston Medical Center. “I don’t think it’s appropriate to put herbal things that are actually drugs in brownies or food items that are attractive to children. I think that’s heinous.” One Lazy Cake, which is wrapped in plastic with a photo of a smiling cartoon brownie, contains 8 mg...

Researchers find red hot Super Fruit aids sleep in older adultsLANSING, Mich., July 12, 2010 – Drinking tart cherry juice daily could help reduce the severity of insomnia and time spent awake after going to sleep, according to a new study published in the Journal of Medicinal Food1. A team of University of Pennsylvania, University of Rochester and VA Center of Canandaigua researchers conducted a pilot study on the sleep habits of 15 older adults. The adults drank 8 ounces of tart cherry juice beverage (CheriBundi www.cheribundi.com) in the morning and evening for 2 weeks, and a comparable matched juice...