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The fountain of youth just might be filled with sweat: Certain types of exercise can help you age better, new research published in the European Heart Journal suggests. In the study, researchers enrolled 266 young, healthy participants who were generally inactive. Then, they split them into four groups: an endurance training group, a HIIT group, a circuit-based weight lifting group, and a sedentary control group. The three exercise groups performed 45-minute sessions three times per week (the control group continued doing what they were doing, which, well, wasn’t much). At the end of six months, researchers looked at the lengths...

Researchers at NYU School of Medicine have, for the first time, identified a single gene that simultaneously controls inflammation, accelerated aging and cancer. "This was certainly an unexpected finding," said principal investigator Robert J. Schneider, PhD, the Albert Sabin Professor of Molecular Pathogenesis, associate director for translational research and co-director of the Breast Cancer Program at NYU Langone Medical Center. "It is rather uncommon for one gene to have two very different and very significant functions that tie together control of aging and inflammation. The two, if not regulated properly, can eventually lead to cancer development. It's an exciting scientific...

Animals that reproduce asexually by somatic cloning have special mechanisms that delay ageing provide exceptionally good health. Scientists at the University of Gothenburg have shown how colony-forming ascidians (or sea squirts) can activate the enzyme telomerase, which protects DNA. This enzyme is more active also in humans who attain an advanced age. "Animals that clone themselves, in which part of an individual's body is passes on to the next generations, have particularly interesting conditions related to remaining in good health to persist. This makes it useful to study these animals in order to understand mechanisms of ageing in humans", says...

Enlarge Image Golden years. Mice without active telomerase (right) look much older than those with the enzyme (left). Credit: Mariela Jaskelioff/Harvard Medical School In F. Scott Fitzgerald's short story, "The Curious Case of Benjamin Button," an old man gets younger with each passing day, a fantastic concept recently brought to life on film by Brad Pitt. In a lab in Boston, a research team has used genetic engineering to accomplish something similarly curious, turning frail-looking mice into younger versions of themselves by stimulating the regeneration of certain tissues. The study helps explain why certain organs and tissues break down...

(BRONX, NY) — A team led by researchers at Albert Einstein College of Medicine of Yeshiva University has found a clear link between living to 100 and inheriting a hyperactive version of an enzyme that rebuilds telomeres — the tip ends of chromosomes. The findings appear in the latest issue of the Proceedings of the National Academy of Sciences. Telomeres play crucial roles in aging, cancer and other biological processes. Their importance was recognized last month, when three scientists were awarded the 2009 Nobel Prize in Physiology and Medicine for determining the structure of telomeres and discovering how they protect...

An unusual enzyme called telomerase acts on parts of chromosomes known as telomeres. The enzyme has recently been found in many human tumors and is being eyed as a new target for cancer therapyEditor's note: We are posting the main text of this article from the February 1996 issue of Scientific American for all our readers because the authors have won the 2009 Nobel Prize in Physiology or Medicine. Subscribers to the digital archive may obtain a full PDF version, complete with artwork and captions. Often in nature things are not what they seem. A rock on the seafloor may...

Researchers investigating an enzyme which permits unlimited cell replication have received the Nobel Prize for Medicine. The enzyme is called telomerase. Telomerase affects telomeres, parts of cells which govern cell replication. According to Bloomberg, human genes are packed into chromosomes, which are topped by telomeres. Telomeres get shorter each time a cell divides -- except in cells with the telomerase enzyme. "When the caps get too short, the cell can’t divide anymore and dies. While the telomerase enzyme isn’t active in most human cells, which stop reproducing and eventually die, it has been found in cancer cells, the Nobel committee...

MONDAY, Sept. 1 (HealthDay News) -- Researchers have revealed the structure of the active region of telomerase, an enzyme involved in both cancer and aging. Telomerase works by adding repeats of a short DNA sequence to the ends of chromosomes -- known as telomeres -- to prevent damage and loss of genetic information during cell division. Telomerase works in embryonic stem cells and other cells that multiply frequently, but is switched off almost entirely in normal adult cells to prevent the dangers of runaway proliferation. In cancer cells, the ability to activate telomerase is often regained. Telomerase has been implicated...

Controversial theorist Aubrey de Grey insists that we are within reach of an engineered cure for aging. Are you prepared to live forever? On this glorious spring day in Cambridge, England, the heraldic flags are flying from the stone towers, and I feel like I could be in the 17th century—or, as I pop into the Eagle Pub to meet University of Cambridge longevity theorist Aubrey de Grey, the 1950s. It was in this pub, after all, that James Watson and Francis Crick met regularly for lunch while they were divining the structure of DNA and where, in February 1953,...

Every species seems to come and go. Some last longer than others, but nothing lasts forever. Humans are a relatively recent phenomenon, jumping out of trees and striding across the land around 200 000 years ago. Will we persist for many millions of years to come, or are we headed for an evolutionary makeover, or even extinction? According to Reinhard Stindl, of the Institute of Medical Biology in Vienna, the answer to this question could lie at the tips of our chromosomes. In a controversial new theory he suggests that all eukaryotic species (everything except bacteria and algae) have an...

WASHINGTON (Reuters) - An early try at making a universal cancer vaccine seems to be safe, and shows some indication that it may even work, researchers at Geron Corp. said on Monday. The first few cancer patients immunized with the vaccine showed no bad reactions and in fact seemed to mount an immune response against their own cancers, the Menlo Park, California-based company said. The results are very preliminary but suggest the research approach is valid, Geron said in a statement. Geron shares rose slightly on the news, to $6.70 a share in mid-morning trading. Geron was scheduled to present...