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US authorizes first pill for COVID-19 treatment at home developed by Pfizer
The National Desk ^ | 12/22/2021 | Matthew Perronne

Posted on 12/22/2021 10:18:36 AM PST by SeekAndFind

U.S. health regulators on Wednesday authorized the first pill against COVID-19, a Pfizer drug that Americans will be able to take at home to head off the worst effects of the virus.

The oral drug, Paxlovid, is a faster, cheaper way to treat early COVID-19 infections, though initial supplies will be extremely limited. All of the previously authorized drugs against the disease require an IV or an injection.

An antiviral pill from Merck also is expected to soon win authorization. But Pfizer's drug is all but certain to be the preferred option because of its mild side effects and superior effectiveness, including a nearly 90% reduction in hospitalizations and deaths among patients most likely to get severe disease.

The efficacy is high, the side effects are low and it's oral. It checks all the boxes," said Dr. Gregory Poland of the Mayo Clinic. "You're looking at a 90% decreased risk of hospitalization and death in a high-risk group -- that's stunning."

(Excerpt) Read more at thenationaldesk.com ...


TOPICS:
KEYWORDS: anthonyfauci; covid; covidstooges; earlycovid; earlytreatment; matthewperronne; obamacare; paxlovid; pfizer; pfizercovidpill; pill; scrolldown; vaccinemandates
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To: upchuck

RE: Some quick scanning of ‘Paxlovid cost’ shows prices in the hundreds of dollars.

Just like the vaccines and monoclonals, it will be paid for by Uncle Sam. You won’t have to worry about the price.


81 posted on 12/22/2021 12:52:53 PM PST by SeekAndFind
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To: Elsie

Indeed the results are stunning. I’m sooooo happy with the results. Trying to get my buddy to go for it. Just amazing.


82 posted on 12/22/2021 12:57:37 PM PST by Sacajaweau ( )
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To: Unmarked Package

Pax...is $500-$700.


83 posted on 12/22/2021 1:00:53 PM PST by Sacajaweau ( )
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To: semimojo
Still, the random use of the mRNA treatment was conducive for the selection of variants in low and high mRNA treatment areas. It is also likely that the variants were created at several locations simultaneously in random events due to the rapid mutations unique to the Coronaviradae. Producing a vaccine or treatment against the Coronaviruses or Adenoviruses is like trying to nail jello to the wall.
84 posted on 12/22/2021 1:45:30 PM PST by vetvetdoug
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To: SeekAndFind

Trust you left the /s off your post.


85 posted on 12/22/2021 1:48:48 PM PST by upchuck (The longer I remain unjabbed with the clot-shot, the more evidence I see supporting my decision.)
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To: gas_dr

I am grateful if we have a therapeutic. Was willing to try Iver/HCQ if needed - but not sure there is any good evidence.

So, if we can take pills that won’t stay in our systems forever and instigate who knows what somewhere down the line, as vaccines more likely can, I’d be happy to have this alternative.

Now, if they’ll just stop with the mandates/force on vaccines, then maybe I can be happy again as America might return to its normal self.

*This ignores the fact I disagree with the whole premise of COVID-19 being an absolutely terrible disease.


86 posted on 12/22/2021 1:50:26 PM PST by the OlLine Rebel (Common sense is an uncommon virtue./Federal-run medical care is as good as state-run DMVs.)
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To: Steve_Seattle

Steve_Seattle wrote: “Your article seems to actually prove what you claim it disproves. The chemicals in the two drugs are very similar, perhaps identical, so they are making a big deal about the dosage. Many times I’ve heard proponents of Ivermectin say that the tests which claim Ivermectin’s inefficacy use far too low of a dose.”

The article clearly demonstrates that the chemicals aren’t ‘very’ similar, and certainly not identical. The proponents of ivermectin like to claim it safe and it is, but not in the high dosages required to be effective against covid.


87 posted on 12/22/2021 3:02:57 PM PST by DugwayDuke (Most pick the expert who says the things they agree with.)
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To: Unmarked Package

Show me a randomized, placebo-controlled, clinical trial of ivermectin that establishes ivermectin as both safe and effective. The pfizer phase three trial had over 40,000 participants. The ivermectin trial should have a similar number.


88 posted on 12/22/2021 3:12:21 PM PST by DugwayDuke (Most pick the expert who says the things they agree with.)
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To: semimojo; vetvetdoug

“vaccinating all during an epidemic creates the ability for a virus to create mutants”

This is one of the more ridiculous assertions floating around here.

SARS-2 is an RNA virus, and RNA viruses are the champions of transcription error. Which results in mutations. RNA doesn’t have the error-checking ability of DNA.

“The delta variant was first detected in India in October 2020, meaning it arose before vaccination began.”

https://www.newscientist.com/definition/indian-covid-19-variant-b-1-617/


89 posted on 12/22/2021 6:42:21 PM PST by Pelham (Q is short for quack )
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To: FreeReign; bray

“A new rumor claims that Paxlovid, Pfizer’s Covid drug, is merely a “dressed up” ivermectin molecule with little difference other than price. The term “Pfizermectin” is even being used to emphasize this. But biochemical and pharmacokinetic data say otherwise. Here are the numbers.”

https://www.acsh.org/news/2021/12/02/how-does-pfizers-paxlovid-compare-ivermectin-15967

“Bottom line

It is abundantly clear that the “Pfizermectin” myth is just that. PF-07321332 is a potent enzymatic inhibitor of Mpro with proven efficacy in clinical trials. Ivermectin has very poor potency in this same assay. Ivermectin, if it works at all, is certainly not functioning as a protease inhibitor.
Based on in vitro studies, Ivermectin is a weak inhibitor of viral replication in cultured cells.

But the antiviral inhibition of ivermectin is weak enough that even at high or multiple doses of the drug blood concentrations do not reach its cellular assay IC50 of 2µM.

PF-07321332 is a potent inhibitor in both the enzymatic and call-based assays.

The drug reaches and remains at blood concentrations sufficient to inhibit 90% of viral replication in cells for one day and does so well below toxic levels.

These data tell us that ivermectin neither inhibits the viral protease in an enzyme-based assay nor slows the production of virus in cells while Pfizer’s drug does both. If ivermectin is proven to be an effective Covid treatment it must be acting by some yet-unknown mechanism.


90 posted on 12/22/2021 6:48:33 PM PST by Pelham (Q is short for quack )
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To: Pelham
that is one of the more ridiculous assertions floating around here

I guess my classes in epidemiology and control of an infectious disease within a population is archaic or no longer in vogue. I was first taught that vaccination in the midst of an epidemic is folly. The selections of mutations that survive the mRNA occurs with the mRNA treatment. Also the variants can occur in several places at the same time due to the rapidity of the mutating Coronavirus. Coronaviruses can mutate in such a way they can avoid the mRNA that is used within the mRNA "vaccine".

91 posted on 12/22/2021 7:54:51 PM PST by vetvetdoug
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To: DugwayDuke
Google is your friend.

You lost me right there...

92 posted on 12/22/2021 8:59:14 PM PST by Usually_Disappointed (This space for rent.)
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To: SunkenCiv

They should have named at Pavlovid.

Btw, Merry Christmas and a Happy, Healthy New Year!


93 posted on 12/22/2021 9:25:50 PM PST by Fred Nerks (fair dinkum!)
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To: LilFarmer

hew has been shown these studies over and over and still denies that the drug is effective against covid-


94 posted on 12/22/2021 9:27:13 PM PST by Bob434
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To: SeekAndFind

So the emergency authorizations of the current shots are all rescinded then ..... Right?


95 posted on 12/22/2021 9:30:03 PM PST by redcatcherb412
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To: Fred Nerks

I am suddenly hungry.


96 posted on 12/23/2021 3:33:18 AM PST by Elsie (Heck is where people, who don't believe in Gosh, think they are not going...)
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To: Elsie

Beats being angry like I am...


97 posted on 12/23/2021 3:50:48 AM PST by Fred Nerks (fair dinkum!)
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To: Fred Nerks

LOL! HH, MC & HNY!


98 posted on 12/23/2021 3:17:26 PM PST by SunkenCiv (Imagine an imaginary menagerie manager imagining managing an imaginary menagerie.)
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To: vetvetdoug

” The selections of mutations that survive the mRNA occurs with the mRNA treatment. “

The Delta mutation occurred in India in October 2020 before any vaccines were rolled out anywhere in the world. It was one of many variants that already existed which is typical of RNA viruses and their inability to copy themselves accurately.

They don’t need any help to screw up, they do it all on their own. Transcription error. The first SARS died out in 9 months all on its own thanks to its inability to copy itself right.

The covid variants we never heard about, and there were many, were all put down by the vaccines. Delta was the first to escape that fate.


99 posted on 12/23/2021 4:12:54 PM PST by Pelham (Q is short for quack )
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To: Usually_Disappointed

Usually_Disappointed wrote: “You lost me right there...”ie, Google is your friend.

Instead of just posting material, why not try to vet/verify using a search engine. Google is one. There are others.


100 posted on 12/24/2021 8:58:06 AM PST by DugwayDuke (Most pick the expert who says the things they agree with.)
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