Posted on 08/01/2023 2:50:43 PM PDT by ConservativeMind
You might not think of diabetes when you think of muscle function. But a common diabetes drug that regulates blood sugar can also prevent muscle atrophy and muscular fibrosis—which can help the elderly bounce back faster from injury or illness.
Researchers have discovered that Metformin can target "zombie-like cells," called senescent cells, which impact muscle function.
Senescent cells secrete factors associated with inflammation that may underlie fibrotic tissue, a hardening or scarring of tissues. Metformin also reduces muscle atrophy.
There's an optimal level of senescent cells that are beneficial, no matter your age.
To test the intervention in humans, the team recruited 20 healthy male and female older adults for a multi-week study. They had participants undergo a muscle biopsy and MRI before the intervention, which involved five days of bed rest. One group of 10 received Metformin and the other 10 received placebo pills during a two-week run-in period, then each group continued the placebo or Metformin treatment during bed rest.
After the bed rest, participants received another muscle biopsy and MRI, then ceased treatments. All patients completed a seven-day re-ambulation period followed by a final muscle biopsy.
"We saw two things in our study," Drummond says. "When participants took Metformin during a bed rest, they had less muscle atrophy. During the recovery period, their muscles also had less fibrosis or excessive collagen. That build-up can make it harder for the muscle to properly function."
The research team examined muscle biopsies from study participants. They found that participants who took Metformin had fewer markers of cellular senescence.
Drummond's team is following up on these findings by examining combining the drug with leucine, an amino acid that promotes growth and could accelerate recovery even further. They've already demonstrated the potency of this combination in preclinical animal studies.
(Excerpt) Read more at medicalxpress.com ...
Good chance removal of sugar from diet cures Type 2 diabetes.
I’m talking about daily sugar intake in the dozens of grams, blood sugar hovering in the 75-125 range.
I just stopped taking Metformin a week ago. After nearly a year, the spontaneous vomiting, feeling like crap, being unable to eat and other issues were too much. Now I’m trying over the counter Berberine and changing what I can.
I wonder if berberine could be substituted for metformin and achieve the same result.
I just started taking berberine. My doctors at Stanford had not heard of berberine, nor had they heard of nattokinase which not only thins my blood a little, it actually fights clots (something my body can’t do). It’s crazy doctors aren’t familiar with solid solutions like that.
Doctors know nothing but the company line from the FDA, CDC and the AMA. Even when you show them proof from recent studies contradicting his force fed dogma. There are no critical thinkers in the medical profession (or I can’t find any).
Reminds me of the D3 deniers of years ago. Turns out they were just dead wrong.
Smart move.
Suddenly, it seems public health officials and physicians are promoting Metformin as a treatment for all types of conditions and illnesses. Anytime I see such a thing, I get worried and start wondering why they want so many people to start taking the drug.
My trust in the health care industry at the moment is almost non-existent. I’m not sure why.
They can’t recommend anything that doesn’t have consensus approval. So they don’t look for word of mouth communication. They will heartily recommend something that they know works and that cannot cause unknown harm or they cannot be sued for. It takes a long time for something to be accepted as true...with drug companies protecting their products reputation by impugning any countering information it will be a long time before things change.
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New!
“Metformin and leucine can help with muscle recovery in persons with diabetes.”
Please don’t read more into this than it actually says. It is not a cure, or not close to a permanent improvement use drug for diabetes. Metformin does not modulate blood glucose or lipids but it does reduces EARLY atherosclerotic lesions. It doesn’t stop them. As time goes on, the hardening of the arteries and heart are part of the diabetic trip. It postpones the act, but eventually it is going to happen if the patient lasts long enough and heart failure becomes a player.
wy69
I have the beginnings of a myopathy problem. I have thought about taking Metformin to experiment but your post really turns me off that idea.
I can tell you that for my particular genetic make up a product from Life Extension makes a huge difference with fatigue and general well being.
I consider in the senolytic category
This is impossible.
You can’t use any drug for off label purposes. They told us so....
“It is not a cure, or not close to a permanent improvement use drug for diabetes.”
I dont think that is the point of this thread.
The drug might be repurposed for something not related to diabetes..which is why I was looking at taking it
That billionaire who is doing that crazy anti aging routine includes metformin in his 2000 pills he takes a day (that is an exaggeration but he does take a lot).
Still, not everybody has that reaction so it may or may not work for you. It's a drug you take in weekly steps, from 1 to 4, at least that's how it worked for me so you can start slow.
Personally, I'm doing whatever I have to, to never need anything like it ever again.
“...fibrotic tissue, a hardening or scarring of tissues. Metformin also reduces muscle atrophy.”
The title of the thread identifies it as a common diabetic drug and the problems it is attempting to handle are consistent with diabetes.
But the side effects to it are a problem:
Feeling sick (nausea)
Being sick (vomiting)
Diarrhea
Stomach ache
Loss of appetite
A metallic taste in the mouth
Low blood sugars, hypoglycemia which can cause death
In rare cases, it’s possible to have a serious allergic reaction (anaphylaxis) to metformin
Lactic acidosis
It can also include a B12 deficiency which can leave you tired, breathless and faint.
A good site for the drug is this MSDS:
https://vionausa.com/wp-content/uploads/2020/01/SDS-Metformin-HCl-ER-Tablets.pdf
wy69
You have again missed the point. It a drug used for diabetes. They are talking about using it for something else. Such as problems after knee surgery.
They are looking to see if it can be repurposed such as what is happening with low dose naltrexone. .or what is done with plaquenil for auto immune diseases. The article isn’t about curing diabetes with metformin
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