Posted on 04/04/2024 12:27:50 PM PDT by Red Badger
One and done...........
Scientists have been searching for the optimal coronavirus vaccine since the Covid-19 pandemic started. The mRNA vaccines developed through the federal government's "Operation Warp Speed" program were a massive innovation; however, annually updating those boosters for specific SARS-CoV-2 variants is inefficient for scientists and patients. SARS-CoV-2 is just one member of the Sarbecovirus (SARS Betacoronavirus) subfamily (others include SARS-CoV-1, which caused the 2002 SARS outbreak, as well as other viruses circulating in bats that could cause future pandemics).
Researchers at the Georgia Institute of Technology and the University of Wisconsin-Madison have developed a new vaccine that offers broad protection against not only SARS-CoV-2 variants, but also other bat sarbecoviruses. The groundbreaking trivalent vaccine has shown complete protection with no trace of virus in the lungs, marking a significant step toward a universal vaccine for coronaviruses.
“We had been working on strategies to make a broadly protective vaccine for a while,” said Ravi Kane, professor in the School of Chemical and Biomolecular Engineering. “This vaccine may protect not just against the current strain circulating that year, but also future variants.”
They presented their findings in “Broad protection against clade 1 sarbecoviruses after a single immunization with cocktail spike-protein-nanoparticle vaccine,” published in the February edition of Nature Communications.
Kane and his research group have been working on the technologies to develop more widely protective vaccines for viruses since he joined Georgia Tech in 2015. Although the team didn’t specifically foresee Covid-19 arising when it did, pandemics have regularly occurred throughout human history. While the team pivoted their vaccine research to address coronaviruses, they were surprised by how rapidly each new variant arose, making their broader vaccine even more necessary.
Once they realized the challenge inherent in how fast SARS-CoV-2 mutates, they had two options for how to build a vaccine: design one to be widely preventative against the virus, or use the influenza vaccine, which updates annually for the anticipated prevalent variant, as a model.
Making a broad vaccine is more appealing because it enables patients to get one shot and be protected for years. To create their general vaccine, Kane’s team capitalized on the key to the original mRNA vaccines — the spike protein, which binds the virus to healthy cells. Their vaccine uses three prominent spike proteins, or a trivalent vaccine, to elicit a broad enough antibody response to make the vaccine effective against SARS-CoV-2 variants as well as other sarbecoviruses that have been identified as having pandemic potential.
“If you know which variant is circulating, you can immunize with the spike protein of that variant,” Ph.D. student and co-author Kathryn Loeffler said. “But a broad vaccine is more difficult to develop because you’re protecting against many different antigens versus just one.”
Collaborators in the Kawaoka group at the University of Wisconsin tested their vaccine in hamsters, which they had previously identified as an appropriate animal model to evaluate vaccines and immunotherapies against SARS-CoV-2. The vaccine was able to neutralize all SARS-CoV-2 omicron variants tested, as well as non-SARS-CoV-2 coronaviruses circulating in bats. Even better, the vaccine provided complete protection with no detectable virus in the lungs.
Kane hopes that the vaccine strategy his team identified can be applied to other viruses — other coronavirus subfamilies as well as other viruses such as influenza viruses. They also expect that some of the specific antigens they describe in this paper can be moved toward preclinical trials. Someday, a trivalent vaccine could comprise a routine part of people’s medical treatment.
Thanks...but, no thanks.
Seriously? People are still getting vaccinated-—for a cold?
Well that’s 15 minutes they’ll never get back.
🔬🤔😳🐑🚫😷💉💊🐂💨💩
Did they control for co-morbidities in the test hamsters? They tend to be chubby… and so darned cute
Uh-huh.
I’ll plan on getting a vaccination right after I return from my trip to the moon.
Hard pass. They lost my trust long ago. I hope the criminals behind the COVID tyranny die alone and in great pain.
How many points are added to your social credit score if you take it twice?
I wonder why Boebert has those blood clots if she never got the vaccine.
I had blood clot in my leg in 2020 way before the vaxxes came out. Sometimes people just get them.........................
If there is some rational fear of MRNA vaccines, don’t let it poison all vaccines. We would not be in the same world without Polio, Smallpox, Measles, Whoopng cough, etc..
I have Factor 5 Leiden. A single gene is transposed, making my blood clot 8x more than an average person. I've had 3 DVT clots in my life and I'm on thinners for life.
Don't know why she got a clot, but not everything comes from the mRNA shots. I never got one of those shots, but in the summer of 2020 had my 3rd DVT in the arch of my right foot.
“Safe and effective” II.
Still a hard NO.
Please stop messing with corona viruses. Just leave the f ing bats alone.
They live in caves and do not seek out humans.
They pose a little threat if they get rabies, but otherwise they are in caves and come out at night when humans are watching TV. They fly way above you eating bugs then they go home. They avoid humans.
Also: Don't take corona viruses out of them and modify the viruses to make them more contagious and deadly, as you did in 2019. Sounds like a pretty simple concept, but you guys in virology can't seem to understand that when you do what you do, you are making illegal bioweapons of mass destruction.
What you do warrants the death penalty. And I and a couple million other people hope to see you hang.
So, as a last request, don't publish and brag about doing this kind of research. It just proves how un-self-aware and clueless you are as criminals, loser science geeks, dweebs, and sociopaths.
Has it crossed your loser minds that the Chinese fund you and let you use their labs so that they can use the bioweapons against us?
I didn't think so.
Let me guess. This one will be repurposed for the fake Bird Flu pandemic, just in time.
If that new vax worked they wouldn’t let us have it, just like they wouldn’t let us have Ivermectin and HCQ.
Many by this point have talked about the impossibility of making a Coronavirus ‘vax’. It won’t work and it wouldn’t be allowed to be produced in the first place, let alone administered, if it did work. Enough of the lies.
This article mentions SARS of 2002.
Dr. Yeadon said a researcher (2 years ago) located survivors of SARS and exposed them to the virus again (with their consent!). Their immunity had remained strong over the 20+ years and they did not become ill.
The researcher then exposed the SARS survivors to what was then called Covid but was another coronavirus. The SARS survivors did not become ill because SARS and the modern influenza virus were similar enough for the body to recognize it.
This makes sense - and it also means we never needed the annual flu vax.
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