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Alzheimer's breakthrough: Discovered the disease's 'ground zero' - paving the way to a cure
Daily Mail ^ | 12/20/17 | Staff

Posted on 12/20/2017 2:41:30 PM PST by x1stcav

Alzheimer's disease is caused by immune cells in the brain triggered by inflammation, according to a breakthrough discovery.

The new research could lead to the development of a drug that treats or even prevents the condition within five years, say scientists.

Experiments found destroying specific cells - known as microglia - reduced the formation of clumps of amyloid beta that form in Alzheimer's and destroy memory.

These are the rogue proteins believed to lie at the root of the devastating neurological illness.

Human trials of all therapies have failed in the past. Most have targeted the amyloid plaques that build up in the brains of patients.

(Excerpt) Read more at dailymail.co.uk ...


TOPICS: Health/Medicine; Weird Stuff
KEYWORDS: alzheimers; amyloidbeta; breakthrough; dementia; inflammation; microglia; protein
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To: x1stcav

“The researchers found the microglia release specks of a protein called ASC in response to it. They stick to the amyloid beta protein - boosting its production.

“Prof Heneka, of the University of Bonn, Germany, said this may even occur in the very early stages of Alzheimer’s.

“In tests an antibody that blocked ASC from binding to amyloid beta stopped it from forming into damaging clumps.

“The study published in Nature found this worked in live mice as well as cells grown in the laboratory.”


21 posted on 12/20/2017 3:41:01 PM PST by NobleFree ("law is often but the tyrant's will, and always so when it violates the right of an individual")
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To: RushIsMyTeddyBear

Same here it runs in my wife’s family too.


22 posted on 12/20/2017 3:44:53 PM PST by painter ( Isaiah: �Woe to those who call evil good and good evil,")
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To: marktwain

“The new research could lead to the development of a drug that treats or even prevents the condition within five years, say scientists.”

FDA will approve it 50 years later.


23 posted on 12/20/2017 3:46:47 PM PST by Bonemaker
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To: erlayman

“That has already been shown in the early stages. Sugar damage reduces functions and completely inhibits other enzymes that allows Alzheimer’s to develop. The reality of what’s possible and maybe not that far off is really exciting and really important! At least for me since I have cut off sugar and artificial flavorings almost entirely.”

Chocolate is my favorite vegetable.


24 posted on 12/20/2017 3:48:19 PM PST by Bonemaker
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To: plain talk

Check out: https://www.caring.com/articles/end-of-alzheimers

What if you could prevent or slow Alzheimer’s disease by tweaking your diet, sleep, exercise and stress management habits?

The Bredesen Protocol is a 36-point comprehensive plan that, if followed, claims to be able to do just that. And it’s supported by research that suggests you could see symptom improvement within six months.

The protocol has been developed by neurologist Dale Bredesen, MD, director of neurodegenerative disease research at the David Geffen School of Medicine at the University of California, Los Angeles.


25 posted on 12/20/2017 3:48:33 PM PST by Bobibutu
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To: x1stcav

BUMP TO THE TOP


26 posted on 12/20/2017 3:55:18 PM PST by Rumplemeyer (The GOP should stand its ground - and fix Bayonets)
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To: Paladin2; zek157

I believe it’s stress that causes the immune system to go bonkers. There are people with the damage that do not have Alzheimer’s. Alzheimer’s and rheumatoid arthritis are correlative. Just my own theory.

I use aspirin (better for ya with milk) most of the time when my arthritis flares so if it’s an anti-inflamatory I HOPE it is also keeping my brain quiet.

Dementia and Alzheimer’s runs in my family...with rheumatoid. I also have fibromyalgia. I sit on my butt all day and stress about everything. I know what I need to do and have a small plan to get it started. Hard thing is that the stress also keeps decisions hard to make. I’m in this swamp.


27 posted on 12/20/2017 4:06:51 PM PST by huldah1776 ( Vote Pro-life! Allow God to bless America before He avenges the death of the innocent.)
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To: huldah1776

I believe you are correct. There is no Alzheimer’s, or even dementia, among my two sets of grandparents. My one grandmother passed at 72, with diabetes and heart attack, though so there is no way to know if dementia “could” have shown up later. Both grandfathers lived to 90+. One of my grandfathers took aspirin every day for at least 10 years. Sharp as a tack, that one.

Both of my paternal aunts had/have Alzheimer’s and some sort of dementia. My dad has Parkinson’s Plus. All three of them are/were diabetic.


28 posted on 12/20/2017 4:22:32 PM PST by madison10 (Merry Christmas!)
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To: editor-surveyor
Not only will this lead to a cure for Alzheimer's, but it will also lead to:

- A lighter battery than can charge faster
- A near 100% efficient solar cell
- A method for generating net fusion energy
- A felony conviction for Hillary Clinton
- An end to the use of the word 'synergy'
- An end to people beginning sentences with 'so'
- Something else which has just slipped my mind

Our future is looking very bright indeed.

29 posted on 12/20/2017 4:35:11 PM PST by who_would_fardels_bear
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To: x1stcav

Let’s hope they never forget the formula....


30 posted on 12/20/2017 4:36:57 PM PST by Vendome (I've Gotta Be Me - https://www.youtube.com/watch?v=wH-pk2vZG2M)
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To: Bobibutu
"The Bredesen Protocol is a 36-point comprehensive plan"

It's as easy as A, B, C, D, ... Z, alpha, beta, ...

31 posted on 12/20/2017 4:36:59 PM PST by who_would_fardels_bear
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To: Bonemaker

Chocolate is wonderful without sugar.


32 posted on 12/20/2017 5:02:12 PM PST by Louis Foxwell (Islam is Satans finest work.)
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To: Bonemaker

I’ve known a few Alzheimer’s patients and the weird thing is that before they came down with it, none of them were interested in these like candy or sweet tea, nor did they put sugar in the coffee. One had early onset Alzheimer’s.

That one became quite a candy cruncher once her ability to recognize people was gone. As she grew worse she would snitch candy anywhere and any time she saw it. It was one of the few things she recognized and if there was any to be found in a room she’d hunt it down.

In each case, it was only after they had full blown symptoms that they suddenly developed an insatiable appatite for hard candy.


33 posted on 12/20/2017 5:32:34 PM PST by piasa (Attitude adjustments offered here free of charge)
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To: DannyTN
This sensitivity is achieved in part by the presence of unique potassium channels that respond to even small changes in extracellular potassium

I've been of the opinion that aluminum is responsible. It was rarer than gold before a process to extract it cheaply was developed. The outbreak of dementia seems to follow it's relative abundance.

34 posted on 12/20/2017 5:37:12 PM PST by Nateman (The louder the left screams , the better it is for America!)
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To: DannyTN

Sounds like an autoimmune response. Which means, the body’s own devices attacking others.

It’s not fun, and not worth keeping unless there is a way to “block” them.


35 posted on 12/20/2017 5:42:56 PM PST by the OlLine Rebel (Common sense is an uncommon virtue./Federal-run medical care is as good as state-run DMVs.)
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To: huldah1776

Everything you mention is all inflammation based.


36 posted on 12/20/2017 6:29:12 PM PST by Secret Agent Man ( Gone Galt; Not averse to Going Bronson.)
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To: x1stcav

Bookmark


37 posted on 12/20/2017 6:52:30 PM PST by aquila48
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To: x1stcav

Give a sugar pill to 100 patients and 22% will be cured. Give a pill that cures 7% and the FDA will let them sell it. Never mind that many drugs are more harmful than no treatment at all


38 posted on 12/20/2017 6:52:36 PM PST by Seruzawa (TANSTAAFL!)
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To: lonevoice

Good news!


39 posted on 12/21/2017 8:51:20 AM PST by Pride in the USA
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To: zek157

>>What causes inflammation? Most likely glucose.

Which must be why natural selection endowed humans with Hepatic gluconeogenesis... uhhh, right?

https://www.google.com/#q=Hepatic+gluconeogenes

Does glycogen inflame the brain?

https://www.google.com/#q=Glycogen+Glucose+Brain


40 posted on 12/26/2017 12:45:45 PM PST by HLPhat ("TO SECURE THESE RIGHTS" -- Government with any other purpose is not American.)
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