I know of several people, friends of friends, who tried acid once and are permanently screwed up. One of them was given it without his knowing he was taking it. I say sentence this guy to one month in San Quentin for each micro gram.
There's this video where they gave small amounts of LSD to some test subjects. They also gave them paper and pens in order to write down all the wisdom they were gleaning during their trips.
After they got down from their highs they all talked about these wonderful inexpressible experiences they had. However, they were not that impressed when they were shown the scribblings they made during their supposedly enlightening trips.