Skip to comments.Specially timed signals ease tinnitus symptoms in first test aimed at condition's root cause
Posted on 01/03/2018 12:20:30 PM PST by Red Badger
A closeup view of the skin-stimulating electrodes and earphones used to deliver the specially timed signals. Credit: University of Michigan
Millions of Americans hear ringing in their earsa condition called tinnitusbut a new study shows an experimental device could help quiet the phantom sounds by targeting unruly nerve activity in the brain.
In a new paper in Science Translational Medicine, a team from the University of Michigan reports the results of the first animal tests and clinical trial of the approach, including data from 20 human tinnitus patients.
Based on years of scientific research into the root causes of the condition, the device uses precisely timed sounds and weak electrical pulses that activate touch-sensitive nerves, both aimed at steering damaged nerve cells back to normal activity.
Human participants reported that after four weeks of daily use of the device, the loudness of phantom sounds decreased, and their tinnitus-related quality of life improved. A sham "treatment" using just sounds did not produce such effects.
Results from tests in guinea pigs and the double-blind human study funded by the Coulter Foundation validate years of pre-clinical research funded by the National Institutes of Health, including previous tests in guinea pigs.
The U-M team has new NIH funding for an additional clinical trial to further refine the approach. U-M holds a patent on the concept behind the device and is developing it for potential commercialization.
"The brain, and specifically the region of the brainstem called the dorsal cochlear nucleus, is the root of tinnitus," says Susan Shore, Ph.D., the U-M Medical School professor who leads the research team. "When the main neurons in this region, called fusiform cells, become hyperactive and synchronize with one another, the phantom signal is transmitted into other centers where perception occurs.
"If we can stop these signals, we can stop tinnitus," she continues. "That is what our approach attempts to do, and we're encouraged by these initial parallel results in animals and humans."
A dual-stimulus approach to treating tinnitus
The approach, called targeted bimodal auditory-somatosensory stimulation, involves two senses. The device plays a sound into the ears, alternating it with precisely timed, mild electrical pulses delivered to the cheek or neck.
This sets off a process called stimulus-timing dependent plasticity, or STDP, which was first explored in animals and led to long-term changes in the rate at which the nerves fire. The approach aims to re-set the activity of fusiform cells, which normally help our brains receive and process both sounds and sensations such as touch or vibration - what scientists call somatosensory inputs.
Under normal conditions, fusiform cells help our brains focus on where sounds are coming from, and help us tune out sensations that result from the movement of our own head and neck.
But the U-M team's previous work in animals showed that loud noise can trigger a change in the nerve cells' activity - altering its timing so that they fire off synchronized signals spontaneously instead of waiting for an actual sound in the environment.
The toll of tinnitus
These events in animals parallel what happens in humans. After exposure to such things as loud noises, head or neck trauma, or other triggering events, some people develop a persistent sensation that they're hearing sounds like ringing or a grinding noise.
Approximately 15 percent of Americans have some level of tinnitus, but the worst symptoms occur in about 10 percent of sufferers, according to estimates based on interviews with nationally representative samples of Americans. Many of those with more severe tinnitus also have hearing loss.
Some cases are severe. As many as two million people can't work or carry out other daily activities because of the tinnitus itself, or the psychological distress it causes them. Tinnitus is the most common cause of service-connected disability among veterans of the U.S. military.
Current approaches to tinnitus treatment focus include efforts to address the psychological distress it causes, for instance through cognitive behavioral therapy. Other approaches use sound to mask the phantom sounds or attempt to modulate the brain response. For more severe cases, some patients turn to invasive, and therefore riskier, approaches such as deep brain stimulation and vagal nerve stimulation. The current approach provides a novel and unique, non-invasive strategy that aims to modulate and correct the aberrant neural pathways that cause tinnitus.
Shore and her colleagues are based in U-M's Kresge Hearing Research Institute, which is part of the Department of Otolaryngology at Michigan Medicine, U-M's academic medical center. Co-first authors Kendra Marks, Au.D., David Martel, M.S.E. and Calvin Wu, Ph.D., are all members of the Shore laboratory.
They recruited a particular kind of tinnitus sufferer for their study: those who can temporarily alter their symptoms if they clench their jaws, stick out their tongues, or turn or flex their necks. These maneuvers, Shore says, appear to be self-discovered ways of changing the activity of fusiform cells - providing an external somatosensory signal to modulate their tinnitus.
The U-M device delivers sounds matched to the loudness and pitch of the phantom sounds that each patient hears. It also delivers mild electrical impulses applied to the area of the head involved in the patients' own tinnitus-altering maneuvers.
The crucial timing of the auditory and electrical stimulation came directly from tests in guinea pigs that had noise-induced tinnitus, reported in the new paper. Those tests showed that specific timing between delivery of the two kinds of stimuli was necessary to suppress the hyperactive fusiform cells.
After patients had the device calibrated to their own tinnitus symptoms, they learned to apply its earphones and electrodes for a 30-minute session each day. Half the group received the bimodal sound-and-electricity treatment for the first four weeks, while the other half received just sounds. Then, they all took a four-week break, and started the next four weeks receiving the opposite of what they'd received before. None of them knew which option they got first.
Every week, the patients took a survey about how much their tinnitus was affecting their lives, and a test of how loud their tinnitus sounds were.
Results in human participants
Overall, the loudness of phantom sounds decreased only after the actual, or bimodal, treatment, but not the sham treatment of sound only. For some the decrease was around 12 decibels, about the magnitude of an electric lightbulb's hum. Two participants said their tinnitus disappeared completely.
The quality of life survey - where a low score indicates less impact from tinnitus - is called TFI, and is measured on a 100-point scale. Statistical modeling of the results revealed that, on average, patients experienced significantly reduced scores for the active treatment, though the size of the effect in individual patients varied. On average, scores also stayed lower for weeks after treatment ended. This effect was not significant for the sham treatment.
No patient experienced a worsening of symptoms or quality of life, or other adverse events. Some said their phantom sounds got less harsh or piercing, or became easier to ignore.
"We're definitely encouraged by these results, but we need to optimize the length of treatments, identify which subgroups of patients may benefit most, and determine if this approach works in patients who have non-somatic forms of the condition that can't be modulated by head and neck maneuvers," says Shore.
The research was funded by NIH grants DC004825 and DC00011, and by the Wallace H. Coulter Translational Research Partnership. The device was built at in2being LLC based on patent 9,242,067 granted to U-M in 2016. The device is experimental and not commercially available; potential cost of treatment has yet to be determined.
Explore further: Bilateral tinnitus in men may be hereditary
More information: K.L. Marks el al., "Auditory-somatosensory bimodal stimulation desynchronizes brain circuitry to reduce tinnitus in guinea pigs and humans," Science Translational Medicine (2017). stm.sciencemag.org/lookup/doi/ scitranslmed.aal3175
Journal reference: Science Translational Medicine search and more info website
Provided by: University of Michigan
Fingers crossed ...
Ain't that the wrong end of the body ?
I have occasional bouts of tinnitus - usually not more than an hour or so per day. As I get older, it is becoming more frequent. Still I am thankful it is not continuous, as it is with some people.
I do have one question, though: How do they tell whether or not a guinea pig is suffering from tinnitus?
He chews faster?.................
Interesting....my tinnitis was likely caused from the needed heavy doses aspirin I had to take about 18 years ago for awhile...so...be careful, folks. (At least my stomach got saved with Deglycerrhized licorice)
Thanks for the ping.
I have tinnitus too. Most of the time my body just ignores it and I do not realize it is there. Sometimes all is quiet if I try to listen for it like right now for instance.
My tinnitus was probably caused by the same thing, plus a lot of loud band music. It is constant now.
“Sometimes all is quiet if I try to listen for it like right now for instance.”
I seem to have the same level of it that you have ... it’s there, but I don’t notice it until it is dead quiet. I think mine is from years of listening to heavy metal on my walkman :-).
One thing I never noticed about it was the change in amplitude of the noise when I move my neck or grind my teeth. While it doesn’t bother me, I’d rather not have it :-).
Mine is a constant high pitched eeeeeeee plus an underlying hiissssss. Sometimes I can tune it out, then I read an article like this which triggers the YOU CANT IGNORE ME instruction in my brain.
Loud rock concerts in high school and college, manufacturing factory floors, wood shop and metal shop, unruffled lawn mowers, homemade explosives, exploding bicycle tires, rifle fire, .357 magnum pistols, loud stereos and headphones, CANAM and TRANSAM car races, power plants — you name it, I did it. Nobody ever told me, not once, “watch it, kid...you’ll harm your hearing.” But would I have listened?
Thanks for posting this.
I go to an otologist every couple years to see if any progress has been made. If you don’t have tinitus, there is no cure. There is a bunch of extra noise in my head that does interfere with normal hearing, even though I can pass mosts hearing tests.
Like the other poster, mine was probably caused by shooting high power rifles with my (totally deaf) father as a youth. Also loud rock music, specifically The Ramones.
To Medical amateurs.
The Vagal nerve is between the Vaginal and the Anal nerves.
The technical term is Taint.
There you learned something.
This is great news.
I’m happy that the FDA will approve it in time for my grandchildren to benefit from it.
Taint ? I call that the Gooch.
Thanks for posting.
Mine is the same as yours, a constant screech with a hisss.
It’s to the point now of interfering with my ability to understand normal conversation.
I catch myself looking at a speakers mouth to make sure I am hearing the right words.
Some nights it even keeps me awake.
I suppose someday I will lose my hearing completely except for this damned noise.
The FDA will never approve any treatment in my lifetime.
I have been exposed to loud noises most of my life. Shotguns, unmuffled farm tractors, unmuffled trucks and motorcycles and loud music.
Picture Grandma’s house and the double bell door ringer in the hallway. Now picture that ringer five feet in front of your head and it’s ringing 24 hours a day. That is my tinnitus.
It came on like someone flipped a light switch, and after 80 hours of no sleep, the hospital knocked me out.
Turns out the tinnitus hertz matched the frequency of my hearing loss, so relief was gained by hearing aids with sound maskers matching the lost frequencies.
Best $7k we ever spent, would have paid that times tem for the relief achieved.
Hard to describe it as a ringing. Its more like a very high radio frequency sound. It could be a beacon from the great ice ship or its a message from outer space that can’t be deciphered. Its always there like a steam radiator valve when it is hot. (Like there are some of you who might remember them? Probably not.)
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