Free Republic
Browse · Search
General/Chat
Topics · Post Article

Skip to comments.

The Fundamental Link Between Body Weight and the Immune System
The Atlantic ^ | 2 Aug 2019 | JAMES HAMBLIN

Posted on 08/05/2019 6:57:02 AM PDT by DUMBGRUNT

They found that healthy mice have plenty of bacteria from a genus called Clostridia, but few from Desulfovibrio, and that their guts let most fat pass right through. Those with an altered immune system had fewer Clostridia and more Desulfovibrio, and this microbial balance helped the gut absorb more fats from food. These mice gained more weight and exhibited signs of type 2 diabetes.

“Whether this applies in humans, we don't know,” Hooper says, “but this is a tantalizing clue.”

The role of the immune system in the gut is to maintain balance. Changes to the body’s defenses, which can happen as a result of age or illness, can cause certain species to flourish at the expense of others.

 The very ideas of “nutritional value” and “calorie content” of food seem to vary based on the microbial population of the person eating it and, potentially, her immune status. A person’s own microbes—and those contained in any given food—would have to be considered as another ­component of the already flimsy calories-in, calories-out equation. This would also compound the challenges already facing nutrition labels.

If all this uncertainty makes nutrition guidelines and nutrition even more inscrutable, it also stands to do some good by undermining the moralizing and simplistic character judgments often associated with body weight. Seeing obesity as a manifestation of the interplay between many systems—genetic, microbial, environmental—invites the understanding that human physiology has changed along with our relationship to the species in and around us. As these new scientific models unfold, they impugn the idea of weight as an individual character flaw, revealing it for the self-destructive myth it has always been.

(Excerpt) Read more at theatlantic.com ...


TOPICS: Chit/Chat; Food; Health/Medicine
KEYWORDS: calories; clostridia; desulfovibrio; diabetes; health; immunesystem; obesity; type2diabetes
Navigation: use the links below to view more comments.
first 1-2021-35 next last
Fat Man's Prayer

Lord, My soul is ripped with riot incited by my wicked diet. "We Are What We Eat," said a wise old man! and, Lord, if that's true, I'm a garbage can. http://wbenton.tripod.com/humor/Jokeindex673.html

1 posted on 08/05/2019 6:57:02 AM PDT by DUMBGRUNT
[ Post Reply | Private Reply | View Replies]

To: DUMBGRUNT

Though there are some great premises in the article, the underlying ignorance of the author and the study is rather incredible.

To-wit:

“By breaking down nutrients and helping them pass through the walls of the bowel, these microbes serve as a sort of gatekeeper between what is eaten and what actually makes it into the body.”

They still have much to learn.


2 posted on 08/05/2019 7:05:03 AM PDT by logi_cal869 (-cynicus the "concern troll" a/o 10/03/2018 /!i!! &@$%&*(@ -)
[ Post Reply | Private Reply | To 1 | View Replies]

To: logi_cal869

They still have much to learn.

Not being my line of work, can you back that up?

A straw man is a form of argument and an informal fallacy based on giving the impression of refuting an opponent’s argument, while actually refuting an argument that was not presented by that opponent. One who engages in this fallacy is said to be “attacking a straw man”.


3 posted on 08/05/2019 7:13:32 AM PDT by DUMBGRUNT ("The enemy has overrun us. We are blowing up everything. Vive la France!"Dien Bien Phu last message.)
[ Post Reply | Private Reply | To 2 | View Replies]

To: DUMBGRUNT

Weight is an individual character flaw when you stay at the table three courses longer than you should, drown your sorrows in alcohol, and distress with a gallon of ice cream.


4 posted on 08/05/2019 7:21:26 AM PDT by greatvikingone
[ Post Reply | Private Reply | To 1 | View Replies]

To: DUMBGRUNT

40 years ago in Med School the number of “gut hormones” known at that time was escalating wildly. Even then there were a number that were known only by their actions and yet to be identified. Part of learning is learning just how much you don’t know and every question answered asks at least twenty more.


5 posted on 08/05/2019 7:23:27 AM PDT by wastoute (Government cannot redistribute wealth. Government can only redistribute poverty.)
[ Post Reply | Private Reply | To 3 | View Replies]

To: greatvikingone

Don’t forget Cheezy Poofs!

https://www.youtube.com/watch?v=jVuX1vrEQoc


6 posted on 08/05/2019 7:26:34 AM PDT by Reily
[ Post Reply | Private Reply | To 4 | View Replies]

To: DUMBGRUNT
If all this uncertainty makes nutrition guidelines and nutrition even more inscrutable, it also stands to do some good by undermining the moralizing and simplistic character judgments often associated with body weight. Seeing obesity as a manifestation of the interplay between many systems—genetic, microbial, environmental—invites the understanding that human physiology has changed along with our relationship to the species in and around us. As these new scientific models unfold, they impugn the idea of weight as an individual character flaw, revealing it for the self-destructive myth it has always been.

An example of a bloated and obese paragraph.

7 posted on 08/05/2019 7:33:23 AM PDT by aspasia
[ Post Reply | Private Reply | To 1 | View Replies]

To: aspasia

An example of a bloated and obese paragraph.

Is that what we used to call big-boned?

50+ years ago a high school chum let be known that his prom date was not fat! She had big bones!


8 posted on 08/05/2019 7:45:23 AM PDT by DUMBGRUNT ("The enemy has overrun us. We are blowing up everything. Vive la France!"Dien Bien Phu last message.)
[ Post Reply | Private Reply | To 7 | View Replies]

To: DUMBGRUNT

Whole body vibration shakes up microbiome, reduces inflammation in diabetes

http://www.freerepublic.com/focus/f-chat/3769316/posts


9 posted on 08/05/2019 7:49:45 AM PDT by DUMBGRUNT ("The enemy has overrun us. We are blowing up everything. Vive la France!"Dien Bien Phu last message.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: DUMBGRUNT

““Whether this applies in humans, we don’t know,” Hooper says, “but this is a tantalizing clue.””

A clue to what? In your own words here from the article you can’t find a use for it even though you invented the theory. And if it doesn’t apply to humans, are we on a save the mice kick to feed the save the spotted owls? Great solution. Ask Hawaii how changing the environment with the protection of animals came out. And why they are over run with chickens.

rwoodf


10 posted on 08/05/2019 8:04:00 AM PDT by Redwood71
[ Post Reply | Private Reply | To 1 | View Replies]

To: greatvikingone

If only you were right instead of just parroting the conventional “just world hypothesis”.

So much that seems true isn’t. There are many things we don’t understand yet about human metabolism, including the individual nature of metabolic efficiency. Many people eat less calories than their skinny counterparts but still remain overweight.

For an article that addresses some of these factors:
https://www.precisionnutrition.com/calories-in-calories-out


11 posted on 08/05/2019 8:11:53 AM PDT by JayGalt (You can't teach a donkey how to tap dance.)
[ Post Reply | Private Reply | To 4 | View Replies]

To: AdmSmith; AnonymousConservative; Arthur Wildfire! March; Berosus; Bockscar; cardinal4; ColdOne; ...
Thanks DUMBGRUNT.

12 posted on 08/05/2019 8:17:01 AM PDT by SunkenCiv (Imagine an imaginary menagerie manager imagining managing an imaginary menagerie.)
[ Post Reply | Private Reply | View Replies]

To: DUMBGRUNT
It is an interesting article... The premise is not new to me. When my appendix ruptured several years ago and I did not go in for treatment for over a week I had developed a bad infection. The surgical team not only had to thoroughly wash off all my intestines, (what a fun job that must have been) they also packed me full of antibiotics. Afterward I started having problems with poor bowel movements.

I took probiotics for years but interestingly enough the most improvement that I have had is when I started eating “organic” salad mix from Costco regularly with a lot of vegetables added from our own garden that we started as a hobby this year. I think that I am getting more diverse and useful organisms introduced into my intestines from that than I got from the pills. If I don't eat the salad for a few days things start getting wonky again. I have never been a believer in “organic” foods having always believed it was just a marketing gimmick.

13 posted on 08/05/2019 8:47:07 AM PDT by fireman15
[ Post Reply | Private Reply | To 1 | View Replies]

Comment #14 Removed by Moderator

To: malach

We planted a bunch of fruit trees this year as well and they were all old enough that almost all of them bore significant amounts of fruit. So I have eaten much more fruit as well. The thing that was a little unusual was that even though the fruit was smaller and not as photogenic as what you find at the grocery store they tasted so much better that they were almost like different fruit altogether. It is interesting that the fruit growers have to plant trees that produce beautiful looking fruit, but the trees that you purchase at a nursery seem to have much better tasting fruit.

And at this point I am starting to believe that your bowel movements are one of the better gauges of at least your nutritional health if not your overall health. Mine turn out much better if I am getting lots of aerobic exercise as well. Stress and anxiety mess them up even if I am doing everything else right.


15 posted on 08/05/2019 11:39:21 AM PDT by fireman15
[ Post Reply | Private Reply | To 14 | View Replies]

To: JayGalt

Informed Freeper here and I stand by my statement that nobody needs more than they need - there is no magic gut biome that lets man eat endless quantities of whatever he wants.


16 posted on 08/05/2019 11:46:38 AM PDT by greatvikingone
[ Post Reply | Private Reply | To 11 | View Replies]

To: fireman15
my appendix ruptured several years ago and I did not go in for treatment for over a week...

WOW!!!

A friend had his appendix let go at a family picnic, he felt crappy and headed home. about halfway, he said it hurt so bad he got out of his truck and walked around? Didn't help.
He then proceeded to the hospital near his home.

They immediately recognized the problem, BUT PAPERWORK FIRST!!!
Not long after, he screamed GIVE ME A KNIFE I'LL F***EN CUT IT OUT MYSELF!!!

He said the pain was incredible!!!

17 posted on 08/05/2019 12:32:20 PM PDT by DUMBGRUNT ("The enemy has overrun us. We are blowing up everything. Vive la France!"Dien Bien Phu last message.)
[ Post Reply | Private Reply | To 13 | View Replies]

To: greatvikingone

OK. We can agree to disagree. My point was that every overweight person is not an over eater.

Neither of our posts suggests that endless quantities of food can be eaten by people and there is a magic way to burn up the calories.

Certainly some people are overweight due to gluttony, others are gluttons & stay slim and others eats moderately, never touching desserts, and are obese. We are not all the same.

There are more things in heaven and earth, Horatio,
Than are dreamt of in your philosophy.
- Hamlet (1.5.167-8), Hamlet to Horatio


18 posted on 08/05/2019 12:37:07 PM PDT by JayGalt (You can't teach a donkey how to tap dance.)
[ Post Reply | Private Reply | To 16 | View Replies]

To: DUMBGRUNT

First off, if you desire a cogent response, don’t go accusing a person of being straw man (a blatant misuse of the term in this case). I almost dismissed your comment, but I’m in a good mood today. I’ve written 250k words in all of my works and performed THOUSANDS of hours of research pursuant to my health recovery and what ultimately resulted in my (still unpublished/unfinished) books.

As stated, there IS some enlightening content in that article, but it will be FIFTY YEARS before they understand the gut (they know next to nothing now).

I know: I recovered from a condition which has no medical name and referenced only by internet-searchable terms.

Furthermore, a doctor was CURING Celiac disease over 70 years ago. So why are people being told that it is incurable???

On the article, just a couple of examples (I have to get back to my day job):

1. “By breaking down nutrients and helping them pass through the walls of the bowel, these microbes serve as a sort of gatekeeper between what is eaten and what actually makes it into the body.”

False. The diverse colony of the microbiome slows the absorption process, permitting digestion of a healthy endocrine system to occur via the excretions of the liver. The microbiome also helps convert nutrients into bioavailable compounds for absorption. The microbiome’s primary role is to protect the intestinal villi, the TRUE gatekeeper of the gut. Absorption is a process referenced as “Transcellular Transport.”

Evidence (PPT with terms for search): https://www.naspghan.org/files/documents/pdfs/training/curriculum-resources/physiology-series/Water_and_electrolytes_final_NASPGHAN.ppt

2. “Researchers have only recently shown that these antibiotics kill off some of the microbes that occur normally in the gut and help livestock, and people, digest food.”

False. This is knowledge nearly half a century old,

Evidence: http://epubs.surrey.ac.uk/847290/1/10798311.pdf

I could go on. In short, this article is a continuation of a biased medical community seeking out single-point fixes for a very convoluted problem with multiple paths of causation...ironically resulting in similar yet very diverse symptoms across the populace.

This is why I tongue-in-cheek coin packaged probiotics “snake oil”: You can take all the probiotics you would like, but they won’t solve a damned thing if the body isn’t permitted to heal. That means REMOVING that which damaged the digestive system in the first place BEFORE permanent damage occurs.

I.e., “leaky gut” (a non-medical term) may not be fully recoverable due to damaged colon. Same goes for Crohn’s and Celiac disease.

Furthermore, a person’s microbiome and, by consequence, their immune system, develops slowly and continuously throughout childhood until around late-teens. The makeup of a person’s microbiome is as much a product of their environment as what a person consumes (and likewise does NOT consume). Until medicine fully-understands the gut, it is more effective for a person in dire straits to buy another’s fecal sample and do a transplant via a Youtube video than seeing a doctor.

That’s the pathetic footnote to all of this crap (pun intended).


19 posted on 08/05/2019 2:09:49 PM PDT by logi_cal869 (-cynicus the "concern troll" a/o 10/03/2018 /!i!! &@$%&*(@ -)
[ Post Reply | Private Reply | To 3 | View Replies]

Comment #20 Removed by Moderator


Navigation: use the links below to view more comments.
first 1-2021-35 next last

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
General/Chat
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson