Posted on 03/13/2020 9:29:51 AM PDT by Hostage
Abstract
The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome (MERS)-CoV underscores the threat of cross-species transmission events leading to outbreaks in humans. Here we examine the disease potential of a SARS-like virus, SHC014-CoV, which is currently circulating in Chinese horseshoe bat populations1. Using the SARS-CoV reverse genetics system2, we generated and characterized a chimeric virus expressing the spike of bat coronavirus SHC014 in a mouse-adapted SARS-CoV backbone. The results indicate that group 2b viruses encoding the SHC014 spike in a wild-type backbone can efficiently use multiple orthologs of the SARS receptor human angiotensin converting enzyme II (ACE2), replicate efficiently in primary human airway cells and achieve in vitro titers equivalent to epidemic strains of SARS-CoV. Additionally, in vivo experiments demonstrate replication of the chimeric virus in mouse lung with notable pathogenesis. Evaluation of available SARS-based immune-therapeutic and prophylactic modalities revealed poor efficacy; both monoclonal antibody and vaccine approaches failed to neutralize and protect from infection with CoVs using the novel spike protein. On the basis of these findings, we synthetically re-derived an infectious full-length SHC014 recombinant virus and demonstrate robust viral replication both in vitro and in vivo. Our work suggests a potential risk of SARS-CoV re-emergence from viruses currently circulating in bat populations.
(Excerpt) Read more at nature.com ...
This is both alarming and somewhat expected. The Muslim usurper hated the United States, as did his handler, ValJar.
Whether it came from eating bat soup or some other animal to human jump or some nefarious biolab we still have to deal with it here among us now. Either way China doesn’t seem to be much help. They just want to save face and all and are now deflecting blame by accusing the US as being the source.
“When this is over, there will be a massive day of reckoning for the globalists who allowed China to develop this stuff.”
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For later
Not to put too fine a point on this but Covid-19 is the disease which is caused by the virus SARS-CoV-2.
It flies around the same tree trunk over and over and over again.
I C W U D T
Yikes. BKMK, even though I had the impression I already knew the circumstance, I’d forgotten the name.
A cluster sounds like a bunch of them,too?
I wonder if he'll be found hanging from a doorknob by a red scarf?
See, since this in China, this is a Mongolian Cluster...
Like Pelosi and Maxine around a Russia collusion hoax. But they use broomsticks to fly.
Hmmm....
Who had “open door Chinese and Russian policy”, and was giving access to all things Russian and Chinese, and making bullions with chinese and Russian govy’s off nearly every subject known to man, through 2015...?
Hmmm.....
Hey man, doesn’t everyone keep their nukes in a cabinate?
You betcha. I got one in my fridge ready to fire up. Any ideas where I should throw it?
yeah well ya know ... Chinese scientists are now saying it’s not that virus see, it’s a different naturally evolved virus from the Wuhan seafood market.
http://freerepublic.com/focus/news/3825876/posts?page=52#52
Just trust China and everything’s fine. That Gates guy, he’a cool dude man (Biden voice).
Yah, I heard they last longer in the frig.
https://web.archive.org/web/20191224151326/https://www.nature.com/articles/nm.3985
Copying it to archive.ph for safekeeping...
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