Posted on 04/30/2020 6:33:20 PM PDT by SeekAndFind
In an article published in Il Tempo, one of Italy’s leading independent newspapers (Britannica.com), Annalisa Chiusolo, a prominent pharmacology researcher, described the mechanism of action of SARS-CoV-2. By understanding this mechanism, it is possible to target and select the most effective drugs against COVID-19 with accuracy and precision. The coronavirus affects the ability of the hemoglobin to transport oxygen, creating the preconditions for lung complications, known to be associated with COVID-19: breathlessness, acute respiratory distress syndrome, and death.
Discovering the theory of viral replication is the first step of any verification. Science proceeds by refutation or confirmation. If this thesis were confirmed, many unknowns would be explained. For example, why COVID-19 affects more men, people with diabetes, fewer women in general, and even fewer pregnant women, very few children, and people with thalassemia. It would close the circle.
Image credit: www.sciencedirect.com
Why Does the Novel Coronavirus Strike Older People More?
It is projected that by 2053, China will become the oldest country in terms of population. This problem can be solved, but the most drastic measure is infecting people with the novel coronavirus. We’ve prepared some facts, and it’s up to you whether to believe them or not.
The virus needs porphyrins for its survival (probably for its replication), so it attacks the hemoglobin (the protein that carries oxygen in the blood), in particular, the OFR10 and OFR3 proteins attack the beta chain, and orph1ab subtracts the porphyrin. The concepts seem a bit abstruse for a layman, but simply speaking, this translates into less oxygen available to the body, with consequent accumulation of carbon dioxide. Thus, the lung cells enter into a state of distress and become the site of the cytokine storm – that is, an enormous immune response – responsible for the acute inflammation that characterizes COVID-19 pneumonia.
The value of hemoglobin in the blood can be an important parameter to assess the SARS- CoV-2 infection: in men, the average value of Hb (hemoglobin) is higher than in women. This would explain the higher incidence of COVID-19 pneumonia in men compared to women, the lower incidence, and the better prognosis in children and pregnant women, where Hb values are lower due to an increased need for iron, which makes less available the "nutrition" of the virus. In elderly or middle-aged patients with diabetes, pneumonia from COVID-19 has a higher incidence, therefore linked to increased Hb glycated in the blood, and therefore there is more "nourishment" for the virus.
The viral damage, therefore, is systemic, i.e., it affects the blood and is not confined to the lung alone. This would also explain the birth of healthy babies from COVID-19 positive mothers. Because in fetal Hb – stay with me, we will now use some technical concepts – two gamma chains replace the two beta chains, a difference is the presence of a residual serine, instead of a histidine present in the same position of the beta chain, probably responsible for the binding with viral proteins, which could mimic the action of 2,3bifosfoglycerate.
All this would explain the lower incidence and better course of the disease in infants, missing the main site of action of viral proteins, i.e., the beta chains of Hb. In short, in infants, the same concept of "nutrition" for the coronavirus is missing.
The same goes for a chronic pathology called Beta-thalassemia, where the "beta" chains of hemoglobin (the target of the virus) are deficient or even absent. This would demonstrate the lower incidence and better prognosis and course of the pathology in thalassaemic beta-thalassaemias, which in Italy are widespread in Mediterranean areas such as Puglia, Sicily, and Sardinia (particularly in the south) where there is a thalassaemia rate of 12% (alpha and beta). To confirm this theory, there is a scientific publication that has put in relation the subjects affected by beta-thalassaemia and COVID-19, in the data taken from PubMed: as of April 10, 2020, 11 cases of COVID-19 positive beta talassaemia were recorded in Northern Italy, where the rate of contagiousness is higher. Ten of them are affected by thalassaemia dependent on transfusion, the most severe form, only one by thalassaemia is not reliant on transfusion.
However, all patients who contracted the virus had comorbidities, very serious diseases: splenectomized, pulmonary hypertension, lymphoma, and chemotherapy. Despite this multi-pathological picture, there were no deaths, no cytokine storms, or severe SARS in the 11 subjects.
Earlier, Dr. Zelenko shared his detailed coronavirus treatment plan based on his own experience in treating COVID-19 patients.
A Detailed Coronavirus Treatment Plan from Dr. Zelenko
We received an exclusive letter from Dr. Vladimir Zelenko again, in which he told his story and shared his COVID-19 treatment plan in detail.
For example, the central mechanism of action of hydroxychloroquine, and its effectiveness in combating COVID-19, can now be fully explained and understood. What this mechanism consists of is immediately stated: the drug, by binding itself permanently with ferriprotoporphyrin (of the Hb group Eme), removes the substrate from the viral proteins and also becomes an important means of prophylaxis. Although there are still no Italian publications on the effectiveness of hydroxychloroquine as a "shield" from the virus, among the directors of infectious disease departments, specialists, primary care physicians, and general practitioners contacted during this research, many have admitted – under the subheading – to using the drug as a “prophylaxis”, i.e., to prevent contagion.
Healthcare professionals who are in close contact with infectious patients take the drug, Hydroxychloroquine in advance, precisely to decrease the likelihood of infection. For now, there is a recent publication, involving 211 people, to support this ”prophylactic” effect. It was published in the International Journal of Antimicrobial Agents, the official organ of the International Society of Antimicrobial Chemotherapy. Of 211 people exposed to COVID-19 positive individuals and prophylaxis with hydroxychloroquine, none were infected.
Can post-exposure prophylaxis for COVID-19 be considered as an outbreak response strategy in long-term care hospitals?
In the context of the ongoing global outbreak of coronavirus disease 2019 (COVID-19), management of exposure events is a concern. Long-term care hospi…
Finally, further confirmation of this hypothesis is provided by the data collected in the register of the SIR (Italian Society of Rheumatology). In order to evaluate the possible correlations between chronic patients and COVID-19 SIR interviewed 1,200 rheumatologists throughout Italy to collect statistics on contagions. Out of an audience of 65,000 chronic patients (Lupus and Rheumatoid Arthritis), who systematically take Plaquenil/hydroxychloroquine, only 20 patients tested positive for the virus. Nobody died, and nobody is in intensive care, according to the data collected so far.
Hydroxychloroquine + zinc is the CoVid condom. Take it early in the process and you won’t get terribly sick, if at all.
Bkmk. I have lupus.
Ping
This irresponsible drug touted by the president has caused another 20 cases of the deadly killer virus. Why does Trump hate those with Lupus?
“Ping”
I second your Ping and raise.
I listened to the Medcram webinar today. Btw, if anyone needs CME credit you can get it for free by watching it. I assume the replay counts.
This is what was said
There is no doubt that Zinc can stop the RNA in the virus from replicating.
There is no doubt that Quercetin acts as a zinc ionosphere.
Trump’s drug has shown it can help people with Covid 19 and zinc..especially if given early.
So connect the dots.
It remains to be see if the dots connect in true fashion with Quercetin, Zinc, and Wuhan Flu.
Dr. Z is a real genius and humanitarian medical doctor.
He uses a very easily understood analogy to describe the importance of treating COVID-19 early, AS EARLY AS POSSIBLE.
He likens the breakout of the disease to a fire. If it’s caught just as it catches fire, chances you will recover in hours and feel normal as if nothing happened.
But if the fire is raging, an entire Fire Department may not be able to rescue you, and no matter the damage will be extensive.
Thanks for posting this excellent piece.
Well, there is one good thing that will come of this, today common sense shit like clean bathrooms at a grocery store, or a Plexiglas divider for a sales clerk that gets sneezed on by 400 customers a day, is becoming the norm. Four (4) months ago had an employee come to the job coughing his lungs out, half the “college educated” managers in this country would have looked down on someone separating themselves or going home, today that may be a bit different.
The Germ-Theory, Pasteur, 180 year ago, taught in 9th grade when I went to school, understood by managers and adults with college educations around the nation starting March-April 2020.
Coming next to America-
Being fat and eating Oreo’s probably kills more people than Corona virus. Oh, wait, that’s a convenience / lifestyle choice and we have “fat acceptance” because the majority is over weight. So we won’t go there.
Excellent share. Thank you!
Ionophore, unless were talking atmosperic science.
He’s looking at the mechanism of action of the virus.
They need to focus on the mechanism of action of individual immune systems, which no one does.
yes, you are correct
Ha-ha
No mention of Vitamin A or D and their role in immune response, and what foods carry those nutrients, and what foods destroy them.
Sounds likely, but where's the original paper?
IT IS SO DISGUSTING that HCQ is not available in the USA as an over-the-counter drug like it is in most other (all other?) nations. WE MUST HAVE MEDICAL FREEDOM!!! People are dead because of an over-regulated corrupt medical establishment.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.