It's all Fight the man! now.
Posted on 05/29/2020 10:36:53 PM PDT by SeekAndFind
“Available evidence of efficacy of HCQ+AZ has been repeatedly described in the media as “anecdotal,” but most certainly is not.”
A new article to be published by Oxford University Press, on behalf of the Johns Hopkins Bloomberg School of Public Health, calls for hydroxychloroquine and azithromycin to be made widely available and promoted immediately for physicians, to be prescribed for early outpatient treatment.
The article, titled “Early Outpatient Treatment of Symptomatic, High-Risk Covid-19 Patients that Should be Ramped-Up Immediately as Key to the Pandemic Crisis,” is authored by Professor Harvey Risch, MD, from Yale University.
Dr. Harvey Risch is Professor of Epidemiology in the Department of Epidemiology and Public Health at the Yale School of Public Health and Yale School of Medicine. Dr. Risch received his MD degree from the University of California San Diego and PhD from the University of Chicago. He was a faculty member in epidemiology and biostatistics at the University of Toronto before coming to Yale. Find his complete bio here.
We Cannot Afford the Luxury of Perfect Knowledge
Professor Risch recognizes that, in an ideal world, randomized double-blinded controlled clinical trials are preferable, yet, regarding ongoing randomized trials with HCQ+AZ, he notes:
“For the earliest trial, between now and September, assuming a flat epidemic curve of 10,000 deaths per week, I estimate that approximately 180,000 more deaths will occur in the US before the trial results are known.”
New Prophylaxis Guidelines Issued in India Rely on Hydroxychloroquine
“In this context, we cannot afford the luxury of perfect knowledge and must evaluate, now and on an ongoing basis, the evidence for benefit and risk of these medications.”
The author describes various studies. He also compares the case fatality rates typically observed without treatment to those with HCQ+AZ treatment.
For example, he notes that there was 12-13% mortality of hospitalized patients receiving placebos in the remdesivir trials both by Wang et al and in the ACT trials sponsored by NIH.
Professor Risch also discusses the issue of adverse events, which brings him to conclude that:
“the FDA, NIH and cardiology society warnings about cardiac arrhythmia adverse events, while appropriate for theoretical and physiological considerations about use of these medications, are not borne out in mortality in real-world usage of them.”
“It would therefore be incumbent upon all three organizations to reevaluate their positions as soon as possible,” writes Professor Risch.
It is Our Obligation Not to Stand By
The analysis by Professor Risch brings him to the following concluding remarks.
“Some people will have contraindications and will need other agents for treatment or to remain in isolation. But for the great majority, I conclude that HCQ+AZ and HCQ+doxycycline, preferably with zinc can be this outpatient treatment, at least until we find or add something better, whether that could be remdesivir or something else.”
“We have a solution, imperfect, to attempt to deal with the disease. We have to let physicians employing good clinical judgement use it and informed patients choose it.”
“There is a small chance that it may not work. But the urgency demands that we at least start to take that risk and evaluate what happens, and if our situation does not improve we can stop it …”
“… but we will know that we did everything that we could instead of sitting by and letting hundreds of thousands die because we did not have the courage to act according to our rational calculations.”
See summary in American Journal of Epidemiology.
See original unedited manuscript at this link.
See also this segment of our video interview with Professor J. Varon about early therapies for COVID-19.
“Follow the science,” except that the “science” is talking out of both sides of its mouth, with contingents of “scientists” taking opposite sides of the same issue.
In other words, useless for anyone to listen to.
Are we still allowed to even discuss the subject of hydroxychloroquine, or is that subject been deemed verboten because of its association with Trump?
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It's all Fight the man! now.
“Are we still allowed to even discuss the subject of hydroxychloroquine, or is that subject been deemed verboten because of its association with Trump?”
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Looks like you are beginning to understand, citizen. Sometimes sacrifice is necessary to advance a better good. What’s a few lives lost in order to paint Orange Man bad.
Just remember, whenever HCQ is mentioned always parrot the narrative...”all legitimate studies show it kills everyone who dares try it, and Trump killed them”.
Exactly.
This treatment could offer relief and potentially save thousands but it’s verboten because Trump might get credit for being ahead of the curve and benefit politically.
HCQ may be part of a cheap, safe and effective treatment for this pandemic but orange man bad.
There are still plenty of real scientists and doctors who are non-political in their profession, intellectually honest with integrity.
I will read back to back articles that say two completely different things..whether they are from scientists or organizations...and they could be two prestigious ones, whatever that means these days.
But you’ll get completely different answers
Yet Andy Cuomo and others will criticize President Trump because he didn’t “follow the science.”
How many lives did he save stopping the Chinese from coming earlier on in the year when schumer and others attacked him for it?
I HATE the left.
But like Michael Corleone said “don’t hate your enemies.It affects your judgement.
And could also get me suspended so I need to step back from all of this right now..the virus...the insane riots...China...the trillions we are spending...
I need a casino to open near me :)
earlier on FR:
Lancet paper on Chloroquine is overhyped - Real World Data should not be a black box
http://www.freerepublic.com/focus/f-bloggers/3849842/posts
quite a bit in the abovecomments at the above about Lancet editor-in-chief Richard Horton.
Horton says China acted “TREMENDOUSLY DECISIVELY” …
Fauci/Birx good in US, but politicians who spread conspiracy theories are bad:
Youtube: 5m48s: 1 May: CGTN: Richard Horton/Lancet: Richard Horton: China’s reaction is decisive and quick
Richard Horton, editor-in-chief of the prominent British medical journal The Lancet, said in an interview with CCTV on Friday that China’s reaction is decisive and quick, including the decision on the lockdown of Wuhan...
https://www.youtube.com/watch?v=nQ61w_lIacQ
he’s also an extreme manmade gloBULL warming hoax alarmist - no surprise:
Youtube: 3m19s: 24 Oct 2019: Health and Climate | Richard Horton/Lancet
‘All health professionals have a duty and obligation to engage in all kinds of non-violent social protest to address the climate emergency’ - Richard Horton
Richard Horton of The Lancet discusses why the climate emergency is “the most existential crisis facing our communities in the world today” and why taking action is “the duty of a doctor”.
https://www.youtube.com/watch?v=YEVGNeneYug
15 Oct 2019: Lancet: Offline: Extinction or rebellion?
by Richard Horton
An unprecedented social and political disruption is about to take place. Nothing like it will have been seen for a generation. The outcome could be transformational. Or it could be met with indifference. Remember the antiglobalisation protests in Genoa in 2001? Or the marches against the Iraq war in 2003? The outcomes of October, 2019, depend on the intensity of resistance. What part should health workers play in one of the greatest social movements of our time? The occasion before us is 2 weeks of non-violent direct political action, beginning on October 7. Billed as an “International Rebellion”, millions of people will gather in cities around the world. They will “continue to rebel against the world’s governments for their criminal inaction on the climate and ecological crisis”. Citizens are encouraged to take as much time off work as possible...
Extinction Rebellion puts it like this: “Because time is running out. We’re almost at the point of no return. The governments are doing nothing. Businesses are doing nothing. The situation is urgent.” There are three demands—first, tell the truth; second, act now; third, go beyond politics to create a citizens’ assembly. A citizens’ assembly will reclaim control from a paralysed political process. To challenge corporate lobbyists. To explore the complexity of our shared predicaments. And to agree solutions. In sum, to break the political deadlock...
The climate crisis is one of the greatest threats to the health of humanity today...
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)32260-3/fulltext
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