SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans

NATURE ^ | 05/26/2021 | Jackson S. Turner, Wooseob Kim, Elizaveta Kalaidina, Charles W. Goss, Adriana M. Rauseo, Aaron J. Sc

[SeekAndFind]

ABSTRACT

Long-lived bone marrow plasma cells (BMPCs) are a persistent and essential source of protective antibodies1–7. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) convalescent individuals have a significantly lower risk of reinfection8–10.

Nonetheless, it has been reported that anti-SARS-CoV-2 serum antibodies experience rapid decay in the first few months after infection, raising concerns that long-lived BMPCs may not be generated and humoral immunity against this virus may be short-lived11–13.

Here we demonstrate that in patients who experienced mild infections (n=77), serum anti-SARS-CoV-2 spike (S) antibodies decline rapidly in the first 4 months after infection and then more gradually over the following 7 months, remaining detectable at least 11 months after infection.

Anti-S antibody titers correlated with the frequency of S-specific BMPCs obtained from bone marrow aspirates of 18 SARS-CoV-2 convalescent patients 7 to 8 months after infection. S-specific BMPCs were not detected in aspirates from 11 healthy subjects with no history of SARS-CoV-2 infection. We demonstrate that S-binding BMPCs are quiescent, indicating that they are part of a long-lived compartment. Consistently, circulating resting memory B cells directed against the S protein were detected in the convalescent individuals.

Overall, we show that SARS-CoV-2 infection induces a robust antigen-specific, long-lived humoral immune response in humans.

[Jane Long]

All Part of Their Plan™

Too bad there isn’t a safe, effective vaccine, to keep people from contracting China virus.

Oh, wait! There is a safe, effective and long used drug preventative that has had as high/higher efficacy and much safer results (overall) than any experimental, unproven shot has.

[WildHighlander57]

Yet a different study says otherwise:

https://freerepublic.com/focus/f-chat/3962726/posts

Maybe the antibodies park elsewhere...

[eyeamok]

Nobody should listen to any studies done in the last 2 years, if you want the real truth, go look at what Real Science said 2 years ago about Natural Immunity from virus’.

[Tallguy]

Appreciate your printing the conclusion in bold... I was starting to wish the author spoke English.