Diabetes: Study of satiety mechanism yields new knowledge (Turns off “full” signal)

Medical XPress / Institut National de la Sante et de la Recherche Medicale / Nature Metabolism ^ | Aug 2, 2021 | Vincent Prévot, et al

[ConservativeMind]

…Leptin, the satiety or appetite-suppressant hormone, is secreted by the adipose tissue at levels proportional to the body's fat reserves and regulates appetite by controlling the feeling of fullness. It is transported to the brain by tanycytes—cells which it enters by attaching to the LepR receptors. Tanycytes are therefore leptin's gateway to the brain, helping it to cross the blood-brain barrier and deliver satiety information to the neurons.

Previous research has revealed that such transport is impaired in subjects who are obese or overweight. This goes some way to explaining their dysfunctional appetite regulation given that it is more difficult for the information on satiety to reach the brain.

In mouse models, the researchers removed the LepR receptor. After three months, the mice experienced a marked increase in their fat mass (which doubled over the period) as well as a loss of muscle mass (reduced by more than half). The total amount of weight gained was only fairly moderate. The scientists also regularly measured the animals' blood sugar levels following the injection of glucose.

They found that in order to maintain blood sugar at normal levels (between 0.70 and 1.10 g/L), the mice secreted more insulin during the first four weeks of the experiment. Three months after removing the receptor, their ability to secrete insulin from the pancreas appeared to be exhausted.

This study elucidates the brain's role in type 2 diabetes and also helps to further research into a disease that until then had not been considered to involve the central nervous system.

"We show that the brain's perception of leptin is essential for the management of energy homeostasis and blood sugar. We also show that blocking the transport of leptin to the brain impairs the functioning of the neurons that control pancreatic insulin secretion," concludes Vincent Prévot.

[ConservativeMind]

Keto brings this signal back very quickly.

[Gene Eric]

>> their dysfunctional appetite

Someone 20lbs overweight shouldn’t rely on comfort signals to slow down. It’s ‘intellectually’ reckless to be obese despite the emotional and physical gratification.

[redinIllinois]

.

[grey_whiskers]

As would intermittent fasting...?

[steve8714]

If we all ate logically, we’d subsist on Soylent.

[Basket_of_Deplorables]

Interesting!!!

[minnesota_bound]

If I stop eating ice cream and bread I lose weight and feel much better.