Posted on 02/04/2022 11:23:32 AM PST by CondoleezzaProtege
The WHO has strongly recommended that doctors use an arthritis drug called baricitinib to treat people with severe or critical COVID-19.
The drug belongs to a class of medications known as Janus kinase (JAK) inhibitors, which block the activity of immune signaling molecules called cytokines.
In severe and critical COVID-19, an excess of cytokines in the body, or “cytokine stormTrusted Source,” sends the immune system into overdrive, with potentially fatal consequences.
After reviewing the latest results from clinical trials, a panel of experts at the WHO concluded that there is good evidence that baricitinib improves survival, reduces the need for mechanical ventilation, and decreases duration of hospitalization.
The drug does not appear to cause any increase in adverse events.
The panel recommends a treatment combination of baricitinib and corticosteroids, which also calm the immune response.
However, the panel advises against combining baricitinib with arthritis drugs called interleukin-6 inhibitors, which have a similar effect on the immune system.
Instead, it recommends that doctors choose either baricitinib or an interleukin-6 inhibitor on the basis of cost, availability, and their clinical experience.
(Excerpt) Read more at medicalnewstoday.com ...
"The panel made a “conditional” recommendation for the monoclonal antibody sotrovimab to treat people who do not have severe COVID-19 but are at high risk of hospitalization.
...The trial found a substantial reduction in hospitalization among individuals at high risk, but “trivial” benefits among people at lower risk.
However, the trial finished before the Omicron variant emerged.
The panel reports that laboratory experiments suggest that sotrovimab can neutralize the new variant but that higher concentrations are required than with the previous variants.
The living guideline already contained a conditional recommendation for using a combination of two other monoclonal antibodies, casirivimab and imdevimab."
Well there’s another medication that will be banned.
We have been using baricitinib for the last six months.
no mention of Viagra?
Nac?
Ruh Roh. Already on a psoriatic arthritis med every 90 day injection.
I wouldn’t trust one thing these criminals recommend....
BAN World Health Organization FROM FACEBOOK AND TWITTER!
DANGEROUS MISINFORMATION WILL KILL PEOPLE!
DIE! DIE!, Die, Die, die, die...everybodies going to ...
ayieeee...
Any idea of the expense of the treatment combination of baricitinib and corticosteroids?
Of Course HCQ is also used for bad arthritis. Gee I wonder.
“We have been using baricitinib for the last six months.”
Have you been telling us about it for the last 6 months?
L
No because there is no frame of reference for it. With the amount of self proclaimed expertise by non clinical people around here I naturally figured they were up to date. That being said i will also say I am underwhelmed by its performance.
For the record it replaced tolciluzimab therapy
😂
You’re not worthy to know about it!!
🙃
“No because there is no frame of reference for it.”
Word salad.
In other words you personally prescribed a drug because you knew it was efficacious against this disease in at least some cases. Then you deliberately withheld that knowledge from others on the forum.
That says a great deal about your character.
L
“That being said i will also say I am underwhelmed by its performance.”
Then why are you still using it after 6 months of “underwhelming” performance?
L
Because there are some advantages. But it is not a silver bullet. And certainly better than remdesivir.
It’s got a pretty nasty immunosuppressive component by design. As such if there is a secondary PNA it’s difficult to justify its use. But it is best in early phase III disease which is also prime time for the emergence of super infection.
Sounds reasonable to me.
Steroids are cheap. Not so much baricitinib.
And you shared none of this with the forum.
Wow.
L
They hit me with two shots of Remdesevir, and I’m fine.
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