Posted on 03/08/2022 12:18:20 PM PST by Red Badger
A medium-chain fatty acid found in energy drinks might one day help protect against heart attack injuries.
"Heart attacks are still a leading cause of death worldwide, that often come with devastating complications," said Zhong Wang, Ph.D., an associate professor of cardiac surgery at the University of Michigan Frankel Cardiovascular Center, who is the senior author on a recent preclinical study in eLife. "Better options are needed to reduce injury to the heart after a heart attack, and even improve heart function. In this publication, we target the interplay between energy metabolism and epigenetics mediated by the medium chain fatty acid 8C."
Wang and colleagues were able to protect against heart attack injury in rat models with octanoic acid, an eight carbon (8C) medium chain fatty acid, as well as a few other metabolites. Those fatty acids produced acetyl-CoA, a building block for energy metabolism, which a stressed heart desperately needs.
The idea is that a physician would administer this therapy to a person once they arrive at the hospital after having a heart attack, to reduce further injury and improve heart function during recovery, he says.
"Understanding the crosstalk between energy metabolism and epigenetics may not only provide an effective target for myocardial infarction, but also have broad implications in other ischemic injury-caused organ damage beyond cardiac diseases," said Ienglam Lei, Ph.D., from the Frankel CVC's Department of Cardiac Surgery and the University of Macau in China, who conducted the study's key experiments.
Wang says the next step would be to test this molecule in large animal models, followed by clinical trials. The research team has been studying the epigenetic regulation of heart attack for more than 10 years.
More information: Ienglam Lei et al, Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via histone acetylation, eLife (2021). DOI: 10.7554/eLife.60311
Journal information: eLife
“the Frankel CVC’s Department of Cardiac Surgery and the University of Macau in China, who conducted the study’s key experiments”
Do I have to say it?
IV Butter?
Where does octanoic acid come from?
Octanoic acid is found naturally in the milk of various mammals and is a minor component of coconut oil and palm kernel oil.
Gee, I thought they milked octopuses!.............
I was sitting here wondering what mammals in the neighborhood I could milk.
But then I realized cows are mammals.
So are they saying Red Bull really does give you wings?
Did the mice get calcium, vitamins D3 and K2, and perform weight-besring exercises?
I don’t know, but if I was a Swiss albino, I’d be worried.
The partial compound, “octanoic acid,” is also known more commonly as “Caprylic acid,” which is a large percentage of better MCT Oils and can be bought by itself.
I haven't been able to find how to create the molecule used, but I would guess salt or sodium bicarbonate might be helpful.
It says the mice were fed a high carb diet with the high fat. It also said the Caprylic acid, when administered with Capric acid, somehow caused little bone concern.
It also says evidence from the major ketone body in ketosis, beta-hydroxybutyrate (BHB), actually helps build bone.
Strange stuff, but when looking at the cross sectional bone pictures, it's unsettling.
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