Could diet modification make chemotherapy drugs more effective for patients with pancreatic cancer? (Keto both stresses and starves cancer cells)

Medical Xpress / The Translational Genomics Research Institute / Med ^ | Mar. 21, 2022 | Steve Yozwiak / Lifeng Yang et al

[ConservativeMind]

The findings of a new study suggest that a ketogenic diet—which is low in carbohydrates and protein, but high in fat—helps to kill pancreatic cancer cells when combined with a triple-drug therapy.

In laboratory experiments, the ketogenic diet decreased glucose (sugar) levels in the tumor, suggesting the diet helped starve the cancer. In addition, this diet elevated ketone bodies produced by the liver, which put additional stress on the cancer cells.

By destabilizing the cancer cells, the ketogenic diet created a microenvironment in which the triple-drug therapy designed by TGen—a combination of gemcitabine, nab-paclitaxel and cisplatin—was more effective at knocking out the tumor, according to the study.

"By limiting glucose availability, the ketogenic diet may promote chemotherapy efficacy," said Professor Daniel D. Von Hoff, M.D., considered one of the nation's foremost authorities on pancreatic cancer.

In addition, the ketogenic diet was shown to have a favorable impact on antitumor immunity by inducing pro-inflammatory tumor gene expression, which further weakened the cancer.

Clinical trials at five locations

To test these laboratory findings, researchers initiated a clinical trial of up to 40 patients at five centers nationwide: Scottsdale, Los Angeles, Connecticut, New Jersey, and San Antonio.

The clinical trial will test whether adding a ketogenic diet to the triple-drug therapy will increase overall survival in patients with pancreatic cancer. This clinical trial began in late 2020 and is anticipated to continue to accrue patients through June 2023. Patients will be randomly assigned to either receive the triple-drug regimen while on a standard diet, while the other half will receive a ketogenic diet and the triple-drug therapy.

"Our laboratory experiments show that a ketogenic diet changes pancreatic cancer metabolism and its response to chemotherapy," said Haiyong Han, Ph.D., and one of the study authors and a designer of the study's experiments.

[ConservativeMind]

It seems reasonable that changing the conditions that helped encourage a malady could affect, or even reverse, that same concern.

[ConservativeMind]

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This potentially high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to implement for your benefit.

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[BobL]

Jason Fung wrote a book on exactly this: “The Cancer Code”.

As usual, years ahead of the ‘experts’.

[alternatives?]

If they wouldn’t honestly test Ivermectin, they can go fly a kite.

[BobL]

LOW CARB / KETO PING!!!

Nice find CM! Linkage between Keto and controlling cancer starting to show up...

[p.s., anyone wanting to join, or leave, my Low-Carb ping list, just let me know, privately or publicly]

[Vermont Lt]

Having experienced six months of chemo for PC (my wife) I can assure you that eating ANYTHING is an accomplishment.

[lurk]

Our oncologist said the science is still unsettled on carbs and cancer.

[Vermont Lt]

For Pancreatic cancer? That’s cute.

[ConservativeMind]

It is also not settled on lots of carbs and cancer.

[alternatives?]

No, for Covid. They weren’t cute. Once they lie, why trust them about anything?

[freespirit2012]

Wow.. Thanks for the link. I have a close friend who is in the midst of chemotherapy for pancreatic cancer. I have sent her the info, and a link to the trial.

[ConservativeMind]

Get her the studies from these posts, too:

https://freerepublic.com/focus/search?m=all;o=time;q=quick;s=pancreatic%20

[ConservativeMind]

And this one:

Team discovers that a derivative of vitamin B3 prevents liver cancer in mice

The inverse relationship between NAD+ and cancer awakened the curiosity of the researchers: could an increase in NAD+ have beneficial effects on the disease? When the scientists supplemented the diet in genetically modified mice with nicotinamide riboside, a derivative of vitamin B3 that increases intracellular levels of NAD+, they did not observe tumour development. Surprisingly, when they gave this diet to mice that had already developed the disease, the size of the tumours was reduced and they eventually disappeared.

The results have been reproduced in other types of cancer such as pancreatic cancer. “We observed the same results in mice with pancreatic adenocarcinoma with regards to DNA damage, so we could conclude that this treatment is effective on tumours caused by oncogene-induced DNA damage and thus, deficit in NAD+,” says Krishna Tummala, first author of the study.

In addition to working with the mouse model, the authors have collated the results of nearly a hundred human samples. “Those from patients with HCC contain URI levels that double those of healthy samples,” according to the article. The data, which also associates URI with a worse prognosis or evolution of the illness, suggests that the gene could be a possible new HCC marker, and nicotinamide riboside boosting NAD+ levels may have a human relevance.

https://medicalxpress.com/news/2014-11-team-derivative-vitamin-b3-liver.html

[freespirit2012]

Thanks, good information. I did pass on the one about the BP meds to her, will send her the others. She just recently (about 6 weeks ago) started chemotherapy, is at stage 2 right now. I don’t think her doctor is at the top of his game, from what I know.

[AuntB]

Bookmark
Thank you

[ConservativeMind]

I can tell you a relative with a 2 inch liver tumor, showing on an X-ray, had the tumor disappear in a follow up X-ray, the day before he was to have surgery. The doctor was stunned and my relative told him what he did and gave the study to him.

The only thing he did different was take nicotinamide riboside for a month and a half before the operation. I sent it supplement bottles to him. He took the prior formula version of this supplement:

https://smile.amazon.com/Thorne-Research-ResveraCel-Nicotinamide-Resveratrol/dp/B097Z5387H

He took three of the prior formula capsules a day. They had nicotinamide riboside before, now this has other molecules added. I'd probably tell my brother-in-law to take three of these, still, for his size, 450 mg a day of pure nicotinamide riboside was close to the study dose.

I believe the other compounds included, including quercetin, helped, and there are studies on each showing they should help.

[ConservativeMind]

Very few doctors are “at the top of their game.”

They are used to giving out old information with old treatments—and believing they are much better than they are.

[Reeses]

As carbs are reduced, a person can also drop down to eating once per day instead of 3 times, which has additional benefits. The 3 times thing was invented in response to the blood sugar roller coaster ride from unnaturally high carb consumption.

Until recently, sugar was considered an expensive spice, imported from afar by adventurous traders, not a primary fuel source.

[Delta 21]

My lame attempt at carnivore feeding has me feeling better and down to 2 meals a day eating all the meat I want. You get carbs from breathing so eliminating them where ever possible is key. Meat, eggs and dairy for protien. It’s an elimination type diet so excluding stuff helps you zero in on specific triggering foods

[sauropod]

Bkmk