Posted on 06/30/2022 7:10:46 AM PDT by ConservativeMind
Mitochondria are the power plants of cells, and they contain their own genetic material and RNA molecules. Scientists have now discovered that certain modifications in mitochondrial RNA boost the invasive spread of cancer cells by supporting protein synthesis in mitochondria. They have established that a specific gene expression signature correlating with high levels of mitochondrial RNA modifications is associated with metastasis and poor prognosis in patients with head and neck cancer. When the researchers blocked the responsible RNA modifying enzyme in cancer cells, the number of metastases was reduced. Certain antibiotics that suppress protein synthesis in mitochondria were also able to prevent the invasive spread of cancer cells in laboratory experiments.
Mitochondria are tiny, membrane-enveloped structures known as the powerhouse of every cell in our body. For energy production, they use the so-called respiratory chain present in the mitochondrial membrane. Because mitochondria contain their own genetic material, they themselves produce key components of the respiratory chain.
A specific enzyme, the methyltransferase NSUN3, is responsible for the m5C RNA modification. When the scientists switched NSUN3 off, the mitochondrial tRNA was less modified and the invasive spread of the cancer cells decreased.
Could NSUN3 function as a biomarker for metastatic cancer? Gene expression signatures indicating high cellular NSUN3 levels and elevated m5C levels were indeed predictive for lymph node metastases and more severe disease progression in patients with head and neck cancer.
Certain antibiotics curb mitochondrial protein synthesis without affecting general protein synthesis in the cell's plasma. The researchers therefore assumed that these agents should affect cancer cells similarly to loss of NSUN3. Indeed, treatment with antibiotics such as chloramphenicol or doxycycline, reduced the invasive spread of cancer cells. Antibiotic administration also reduced the number of lymph node metastases in a mouse model.
(Excerpt) Read more at medicalxpress.com ...
Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis (Doxycycline):
https://www.ncbi.nlm.nih.gov/books/NBK556599/
It had to be doxy...
Doxycycline is an extremely common antibiotic, but longer term use is not a common practice, except when treating malaria.
..........
Not true. Doxycicline is often used long term for many problems, especially gyn, sinus and lung,
Doxycycline is an extremely common antibiotic, but longer term use is not a common practice, except when treating malaria.
..........
Not true. Doxycicline is often used long term for many problems, especially gyn, sinus and lung,
Doxycycline reduces those RNA modifications.
From the first paragraph from the write up at the link, which I also placed above:
“When the researchers blocked the responsible RNA modifying enzyme in cancer cells, the number of metastases was reduced. Certain antibiotics that suppress protein synthesis in mitochondria were also able to prevent the invasive spread of cancer cells in laboratory experiments.”
Doxycycline is an extremely common antibiotic, but longer term use is not a common practice, except when treating malaria.
Is it still used long term for rosacea?
Instead of long term Doxy use look at other things that were used to deal with Malaria and repurpose them.
They have looked at Ivermectin and HCQ.
I saw some studies dealing with Ovarian cancer.
However, people who are on Plaquenil probably still get cancer. They should look if it is less.
I now have a script for it. Been putting off taking the drug
The dose of doxycycline usually prescribed is actually not high enough to even have any antibiotic activity. Since the antibiotics are prescribed at such low doses there are minimal long-term side effects. When using low doses of antibiotics at anti-inflammatory doses, studies have shown long-term use to be safe.
https://www.healthgrades.com/right-care/rosacea/is-long-term-antibiotic-use-for-rosacea-safe
Thanks for the clarification because I was getting cornfused.
Individuals on long-term exposure to hydroxychloroquine/chloroquine are not at lower risk of cancer. However, hydroxychloroquine/chloroquine may lower the risk of metastatic cancer and death.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679565/
if you have cancer and are on chemo...I continue to be amazed at how things that are used to treat malaria might be able to be repurposed
“Hydroxychloroquine induced lung cancer suppression by enhancing chemo-sensitization and promoting the transition of M2-TAMs to M1-like macrophages
https://jeccr.biomedcentral.com/articles/10.1186/s13046-018-0938-5
Thanks.
The half-life of Plaquenil is about 40 to 50 days. In other words, it takes about 40 to 50 days for your body to get rid of half of a dose of Plaquenil. It typically takes about five half-lives for a drug to leave your body completely. This means that Plaquenil stays in your system for about 200 to 250 days.
interesting. I will have to look more into. I am suppose to take 400 mg a day
Yeah, that’s a lot. I can’t alter your scrip of course, but...2nd opinion mebbee?
I just looked at the half life of another drug I take. 20 hours.
Any idea why Plaquenil lasts so long in the body?
That dosage seems to be to me for more advanced autoimmune issues. I have to really research this.
I dont like taking drugs because so many unknown side effects
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.