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Loss of male sex chromosome leads to earlier death for men (40% of 70 year olds lose “Y”)
Medical Xpress / University of Virginia / Science ^ | July 14, 2022 | Soichi Sano et al / Andreas Zeiher et al

Posted on 07/14/2022 10:00:07 PM PDT by ConservativeMind

The loss of the male sex chromosome as many men age causes the heart muscle to scar and can lead to deadly heart failure, new research shows. The finding may help explain why men die, on average, several years younger than women.

Kenneth Walsh, Ph.D., says the new discovery suggests that men who suffer Y chromosome loss—estimated to include 40% of 70-year-olds—may particularly benefit from an existing drug that targets dangerous tissue scarring. The drug, he suspects, may help counteract the harmful effects of the chromosome loss—effects that may manifest not just in the heart but in other parts of the body as well.

On average, women live five years longer than men in the United States. The new finding, Walsh estimates, may explain nearly four of the five-year difference.

…The scientists also looked at the effects of Y chromosome loss in human men. They conducted three analyses of data compiled from the UK Biobank, a massive biomedical database, and found that Y chromosome loss was associated with cardiovascular disease and heart failure. As chromosome loss increased, the scientists found, so did the risk of death.

Walsh notes that one potential treatment option might be a drug, pirfenidone, that has been approved by the federal Food and Drug Administration for the treatment of idiopathic pulmonary fibrosis, a form of lung scarring. The drug is also being tested for the treatment of heart failure and chronic kidney disease, two conditions for which tissue scarring is a hallmark. Based on his research, Walsh believes that men with Y chromosome loss could respond particularly well to this drug, and other classes of antifibrotic drugs that are being developed, though more research will be needed to determine that.

At the moment, doctors have no easy way to determine which men suffer Y chromosome loss.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: bigpharma; chromosome; dealers; drugpushers; earlydeathtoobadmen; malechromosome; y
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To: ConservativeMind
Losing your Y chromasome? Whaaa?


21 posted on 07/15/2022 4:51:49 AM PDT by z3n (Kakistocracy)
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To: ConservativeMind

How does this affect trannies though.


22 posted on 07/15/2022 4:53:31 AM PDT by Houserino
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To: higgmeister

Men have two testicles.

One has X and one has Y.

Which ever testicle the sperm comes from determines the sex of the baby.

So losing a testicle can result in the loss of Y.

I have been studying the new public school ‘health’ ed.


23 posted on 07/15/2022 5:38:01 AM PDT by Scrambler Bob (My /s is more true than your /science (or you might mean /seance))
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To: Secret Agent Man
Keeping testosterone up can prevent a lot of problems as you age.

It can also cause a bunch a problems as the growth hormone can cause the wrongs stuff to grow like cancer cells.

24 posted on 07/15/2022 5:44:43 AM PDT by usurper
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To: ConservativeMind
"See Mandrake? I was right. Lose your essence to a woman...and you lose your life."


25 posted on 07/15/2022 5:44:59 AM PDT by moovova
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To: joshua c

But it’s science. You must believe.

/s


26 posted on 07/15/2022 6:29:12 AM PDT by Sequoyah101 (Politicians are only marginally good at one thing, being politicians. Otherwise they are fools.)
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To: usurper

Growth hormone and Test are two different substances.


27 posted on 07/15/2022 6:34:57 AM PDT by Dead Corpse (A Psalm in napalm...)
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To: FarCenter

Good article. Thank you for sharing that.


28 posted on 07/15/2022 7:20:16 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

I had my Y chromosome out playing with it last week.

Now I can’t find it.


29 posted on 07/15/2022 7:46:49 AM PDT by DannyTN
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To: GaltAdonis

I had a similar thought when I woke up one morning to find my ass had fallen off. I looked in the cushions and around the yard but I cant find it. I even used a flashlight.

Nobody has replacements online, probably ripples from the plandemic or Putins fault.

I dont know what Im going to do. Maybe I can get on a transplant list.


30 posted on 07/15/2022 8:28:17 AM PDT by gnarledmaw (Hive minded liberals worship leaders, sovereign conservatives elect servants.)
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To: dandiegirl

yes, the results have exceeded my wildest expectations.
But please remember, my exercise habit started long ago, and it was a slow and gradual progression. The key is regular exercise, not hard exercise once one gets to Medicare age.


31 posted on 07/15/2022 8:31:08 AM PDT by entropy12 (Trump/DeSantis & MAGA! are the only way to keep USA viable. Are so many somany)
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To: lee martell

Women live longer than men because men start accumulating iron earlier.


32 posted on 07/15/2022 8:31:52 AM PDT by TTFX
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To: ConservativeMind

At 70 who cares your not using them anyway.


33 posted on 07/15/2022 8:45:39 AM PDT by Vaduz ( )
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To: Nervous Tick

Nah, it’s God’s way of giving the guy a break before eternity REALLY sets in.


34 posted on 07/15/2022 8:49:01 AM PDT by Night Hides Not (Remember the Alamo! Remember Goliad! Remember Gonzales! Come and Take It!)
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To: ConservativeMind
One way to get some extra? I'm sure there are a few things that can be picked up in the pool.


35 posted on 07/15/2022 8:55:54 AM PDT by Libloather (Why do climate change hoax deniers live in mansions on the beach?)
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To: ConservativeMind

WTH?!


36 posted on 07/15/2022 10:42:30 AM PDT by Az Joe (Biden & ChiComs are the enemy, not Putin.)
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To: ConservativeMind

At the moment, doctors have no easy way to determine which men suffer Y chromosome loss.


That’s easy.

The dead ones.


37 posted on 07/15/2022 12:17:40 PM PDT by DuncanWaring (The Lord uses the good ones; the bad ones use the Lord.)
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To: gnarledmaw
"...my ass had fallen off..."

They say that laughter is the best medicine -
and it IS up until the point when you laugh your ass off.
Then the fun is gone...

/s

38 posted on 07/15/2022 1:03:57 PM PDT by GaltAdonis
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To: usurper

The problems are more likely to occur if you take it. Much less so than if you take herbs and such that allow your body to continue to make it normally.


39 posted on 07/15/2022 4:34:14 PM PDT by Secret Agent Man (Gone Galt; not averse to Going Bronson.)
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To: Still Thinking

How can you lose a chromosome?

About as easy as ‘losing’ my car keys or cell phone?


40 posted on 07/16/2022 6:23:03 AM PDT by Tahoe3002 (Yes, indeed!)
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