Examining how poor diet damages blood vessels (Diet can fix liver, but not kidneys)

Medical Xpress / Leipzig University / Nature Metabolism ^ | Nov. 21, 2022 | Olga Bondareva et al

[ConservativeMind]

Over the course of the last several decades, the rate of obesity has progressively increased and is now one of the leading causes of death worldwide—650 million adults are classified as obese. The World Health Organization (WHO) defines obesity as the accumulation of excessive fat in the body creating risks for a healthy life. The main causes: changing diets and lifestyles. But what are bad eating habits doing to our blood vessels?

A research team led investigated how obesity impacts blood vessels' structure at a molecular level.

The team's research illustrates that metabolic disease affects blood vessels in different organs of our body in a unique way. For instance, blood vessels in the liver and fat tissue struggle to process the excess lipids, kidney vessels develop metabolic dysfunction, lung vessels become highly inflammatory, and transport across the brain vessels is defective.

"As vascular dysfunction drives all major pathologies, from heart failure to atherosclerosis and neurodegeneration, our research shows how bad eating habits molecularly promote the development of diverse diseases," explains Dr. Olga Bondareva.

"We want to elucidate molecular mechanisms of obesity in order to be able to offer patients tailor-made therapies in the future," adds Professor Matthias Blüher.

The researchers then asked whether a healthy diet could reduce the disease-causing molecular signatures induced by a bad diet. Their results show that a healthy diet can indeed improve the molecular health of blood vessels, albeit only partially. For instance, the blood vessels in the liver recovered nearly completely, but blood vessels in the kidneys retained the disease signature, despite a healthy diet and significant weight loss. This means that some of our blood vessels can develop a "memory" of metabolic disease, which is difficult to reverse.

[ConservativeMind]

The good news is that we can reverse liver blood vessel damage through diet, by reversing metabolic dysfunction, but this is not enough for our kidneys.

I can say my eGFR has improved this last test by 8% using creatinine and 12% when using Cystatin-C for eGFR, for the first time. This was even without the adjustments for height and weight, now encouraged. When you add those in, my eGFR shot up over another 30 points, showing my kidneys were actually over 40% better than was previously shown, all together.

I would say that you can positively affect your eGFR, despite this study’s conclusion.

[ConservativeMind]

The “Take Charge Of Your Health” Ping List
This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

[Skywise]

I thought creatine use wasn’t recommended if you had kidney issues?

[Paladin2]

I’m not seeing what constitutes a Good Diet.

[ConservativeMind]

eGFR tests use creatinine clearance to determine filtering ability.

Creatinine is different than creatine, and you take neither for your eGFR creatinine-based kidney function test.

Cystatin-C is a newer alternative, believed to be more accurate, and it showed my kidneys were better than what the normal creatinine eGFR test saw.

[ConservativeMind]

In this case, it was losing weight and getting rid of one's metabolic dysfunction.

You can do that with a lot of exercise, fewer calories, fewer carbs, etc.—whatever allows you to get your blood sugar and insulin to properly work again.

I personally believe that a lower/low carb approach is the better food approach to getting there, but a higher carb diet without simple sugars and reasonable exercise can do it, too.

[Skywise]

Hah! Sorry, I completely misread that!

[Secret Agent Man]

There are herbs that can improve kidneys, and many more, the liver.

[sauropod]

.

[gundog]

.... and many more, the liver.

Salt, pepper, garlic and onions. Maybe a little ketchup.

[Secret Agent Man]

Yep.

Best herb for the liver: milk thistle. Can allow the liver to regenerate itself.

[House Atreides]

“ There are herbs that can improve kidneys, and many more, the liver.”
************************************************************

I prefer my liver fried… with onions. ;-)

[minnesota_bound]

The trick is to stop.... I am writing this while drinking a glass of soda and a glass of water. The soda somehow empties first and sometimes second etc before I need to refill the glass of water.....

What Happens If You Stop Eating Sugar for TWO Weeks
https://www.youtube.com/watch?v=cPyFIvCvh8U

All sorts of videos on various health issues here:

Dr. Eric Berg DC
https://www.youtube.com/c/DrEricBergDC/videos
.........................................

The Mullein Leaf Capsules 1500mg I have been taking seem to work. I take 2 a day.
This is my 4th day and I have had 2 nights with no issues with that uncomfortable swelling / tingling feeling in the lower legs.
It was gone. The other days were less of an issue then before but there at night. It could be what you last eat as well and when you take the Mullein Leaf Capsules makes the difference.

I am also taking 2 capsules of Nature’s Bounty Cinnamon 1,000 mg Caps.
“Cinnamon does have antioxidant, antibiotic, and anti-inflammatory properties”

Maybe the two combined are helping.

Mullein Leaf Capsules 1500mg
https://www.amazon.com/dp/B091FXD4C5?psc=1&ref=ppx_yo2ov_dt_b_product_details

[RoosterRedux]

Dr. Berg is excellent.

[RoosterRedux]

In Dr. Berg's video on stopping sugar for 2 weeks he mentions the medical industry's approach to diabetes. They talk about being overweight, eating too much fat, lack of exercise, even living in an urban environment as being bad for this condition. But they never mention too much sugar (or carbs, that are converted into sugar).

As usual the medical industry is late to the party.

Even my own doctor, who I believe is excellent, was unaware of the benefits of the keto diet until I showed her how it affected my stats. I did so by slipping off the diet for a while--inadvertently eating some hidden carbs that were too tasty to resist. When she commented on my rise in blood pressure and bad cholesterol, I admitted I had added some "low carb" tortillas to my diet that I suspected weren't actually low carb. My test strips indicated that I was no longer in ketosis.

Long story short, I told her I would immediately return to my regular keto diet right away and we could see if it had any effect when I had my next blood workup.

Well, you can guess the results. Next bloodwork showed everything previously bad was now in good order...and I had lost 5 lbs.

She was sold and decided to look into everything keto.

She said that the medical industry was slow to adapt because there was an orthodoxy to medicine and a hesitancy to move to new treatments. Ergo, that is why you can't expect your doctor to be on the cutting edge of discovery. Of course, keto has been around for a very long time (I have been on--and off--it since the 1970s), so I can't understand the resistance.

[Paladin2]

Thnx.

[iontheball]

The most important thing one can do to preserve any organ in the body is to stay the hell away from the spike protein.