[MtnClimber]

Much more at the source link. I only excerpted intro and conclusion parts of the explanation.

I would be interested in critiques from anyone with an Immunology background.

[Jim Noble]

It’s VERY interesting.

Of course, vaccination’s protection against severe disease is mediated through T cells, not through antibodies. I saw a preprint last night that claims there’s no cellular immune boost after 3 doses of an mRNA vaccine (that is, 4, 5, etc don’t ADD to protection against severe disease).

But the IgG4 story as a cause of repeated non-severe infections looks good as well.