Posted on 02/25/2023 3:38:05 PM PST by ConservativeMind
Psyllium fiber protects against ulcerative colitis and suppresses inflammation by activating the bile acid nuclear receptor, a mechanism that was previously unrecognized, according to a study.
The findings reveal that psyllium inhibits inflammation that can lead to colitis in mice by increasing serum bile acids, resulting in the activation of the farnesoid X receptor (FXR), a bile acid nuclear receptor.
Fiber-rich foods promote intestinal and metabolic health, but the extent of protection varies for each fiber type. It has been unclear whether dietary fiber can benefit severe forms of intestinal inflammation, such as Crohn's disease and ulcerative colitis, which are collectively known as inflammatory bowel disease (IBD).
This study was designed to identify specific fibers that might protect mice in two models of experimental colitis. The study also investigated the mechanism by which protective fibers might suppress inflammation.
Several fibers were tested, including inulin, cellulose, pectin, glucomannan and psyllium. The authors found psyllium has the unique ability to improve two chronic inflammatory states: metabolic syndrome and colitis.
"The results were impressive in that even modest amounts of psyllium provided strong protection in both colitis models," said Andrew Gewirtz.
"That psyllium can offer protection against colitis fits with limited human studies that psyllium is effective in maintaining remission of ulcerative colitis, but its mechanism of action was largely unknown," added Alexis Bretinz
Psyllium led to an increase in bile acids that resulted in activation of the FXR bile acid receptor. Such FXR activation was necessary and sufficient to prevent colitis. This suggests that pharmacologic FXR activation might be useful in managing IBD.
"There has been a lack of consensus on the impact of dietary fiber on IBD, and the notion that soluble/fermentable fibers might negatively impact IBD has prompted many patients to consume low-fiber diets," Gewirtz said.
(Excerpt) Read more at medicalxpress.com ...
We use psyillium husk as an ingredient in making low carb flat bread, but I had no idea of its other benefits.
I wish I liked them enough to have it daily.
I found some oral Frankensense so I guess that’s how it helps.
I concur. I recently learned I have divicular disease and I’ve had 3 painful “attacks” in a year. Once was after drinking no water for a few days (I had coffee and wine but minimal other fluids those days) and once was after NOT eating oatmeal every morning for a week as I had been in the habit of doing since the diagnosis. Never again! Oatmeal with fruit and 8 glasses of water daily for me from now on.
Here are several research papers on Frankinsense that reference internal use for just ulcerative colitis. Also used for Khrons and most other digestive disorders.
It is an incredibly versatile herbal remedy backed by tons of research. Here are some of its other uses, arthritis, tumors, inflammation, heart disease this link should keep you busy if interested. Its no wonder it was given as a gift by the 3 wisemen. Hope you enjoy
https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=boswellia+serrata+uses&oq=Boswellia+serrat
Thank you. :)
I take Boswellia extract (65% Boswellia acid) for other reasons; 1,000 mg capsules.
I buy the orange flavored that has a little sugar added.
Thanks for posting. I’ll give it a try.
Metamucil, store brand, or some generic from Amazon.
All are excellent. You might start with a brand you can get reliably, and start slow, then increase. You will know in a day or so. It’s great!
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