Posted on 04/23/2023 2:46:29 PM PDT by ConservativeMind
Researchers show that use of senolytics can improve the reparative properties of human heart cells by eliminating senescent "zombie cells," known to be associated with cardiovascular disease and other age-related conditions
Aging is the greatest risk factor for many life-threatening disorders, including cardiovascular disease and cancer. "Senescence" is the term given to the biological aging process which involves the build-up of senescent cells, called "zombie" cells, which refuse to die.
Zombie cells release chemicals that can be harmful to nearby cells, affecting cell survival and reparative potential. The build-up of these zombie cells in our bodies promotes aging and age-related conditions, including cardiovascular disease.
Professor Georgina Ellison-Hughes recently tested a new group of drugs, known as "senolytics," which eliminate zombie cells.
In lab studies, senolytics have been shown to improve poor physical function and extend health span and lifespan.
For this study, the researchers used a lab model where zombie human heart cells are grown together with healthy human heart cells; cardiomyocytes (the contractile cells of the heart) and endothelial cells (vasculature cells).
The results of the study show that human senescent "zombie" cells decrease survival and cell cycle activity of human cardiomyocytes or endothelial cells. If you eliminate the senescent cells using senolytics (Dasatinib and Quercetin), this improves cardiomyocyte survival and cell cycle activity, and the ability of endothelial cells to migrate and form new blood vessels.
"In a human cardiac cell system we show that senescent cell removal by senolytics shows therapeutic potential in rejuvenating the reparative activity of human cardiomyocytes and endothelial cells. These exciting results open the path to further studies using senolytic therapy to treat age-related heart disorders and the toxic effects of cancer chemotherapy on the heart," says Professor Georgina Ellison-Hughes.
The removal of senescent cells shows promise in rejuvenating the heart's reparative potential.
(Excerpt) Read more at medicalxpress.com ...
Anyone who is not taking Quercetin these days is missing out on a lot of healthy effects:
https://www.health.com/quercetin-health-benefits-6825553
Added quercetin to my supplement stack early on in Covid, probably late Spring 2020.
Agree!!
Great link...for those who may not be aware....even after the past two years.
That’s what I need; the equivalent of Scrubbing Bubbles to clean out the arteries periodically.
I’m switching over this. Drano gives me heartburn.
Do the positive effects require both, or will either do? Quercetin is, of course, non-prescription and easy to get.
That pill has a lot of promoters on this site. I venture to say most have no idea that it is problematic for some people. I suspect many here have no clue as to whether they have a P450 enzyme problem as Doctors don’t pick up on the clues.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822518/
One clue you can look for is if opioids don’t seem to help you the way you think they should. You may have a CYP2d6 problem.
Quercetin is listed on drug interaction tables
you also need to be careful with Quercetin if you are taking HCQ (another favorite drug on this site)
Don’t expect your Doctors to know about this study
https://dmd.aspetjournals.org/content/51/3/293
Look for FDA to start banning quercetin in 3,2,1.....
Do you take quercetin daily or once a month in a megadose?
Do you take Quercetin daily, or once a month in a megadose or not at all?
Daily
Is there any advatage to taking quercetin with bromelin.
Do you do quercetin daily or once a month in a megadose?
One, fisetin didn't work well as as an actual senolytic, according to a study I came across. It worked in mice, though.
Second, it appeared, from other studies, that about half of zombie cells were actually capable of being revived with PQQ, Urolithin A, and GlyNAC, because their mitochondria were severely crippled, yet the cell was still minimally functioning.
We don't take quercetin, at this time, or for awhile, since COVID was once a concern.
Second, it appeared, from other studies, that about half of zombie cells were actually capable of being revived with PQQ, Urolithin A, and GlyNAC, because their mitochondria were severely crippled, yet the cell was still minimally functioning.
.........
It looks like you mean here that PQQ, Urolithin A, and GlyNAC revived zombie cells.
So you don’t take fisetin or quercetin. Since you take PQQ, Urolithin A, and GlyNAC —it sounds like you don’t take any senolytic—because the supplements you do take undermine the effects of the senolytics.
Do I have that right or am I bass ackwards there.
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