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Study shows melatonin, commonly used to improve sleep, can aggravate bowel inflammation (Worsens colitis by hurting gut bacteria)
Medical Xpress / FAPESP / Microorganisms ^ | May 9, 2023 | Ricardo Muniz / Jefferson Luiz da Silva et al

Posted on 05/10/2023 12:06:57 PM PDT by ConservativeMind

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Antibiotics allowed melatonin to help colitis sufferers, but this was counter-intuitive and it might be best to not use melatonin with such disorders, if one notices issues.
1 posted on 05/10/2023 12:06:57 PM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

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2 posted on 05/10/2023 12:09:14 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Wow, now THAT is news I can use! I don’t take melatonin, but who knew?
I certainly won’t take anything that’s gonna make my colitis worse.
I’m currently doing a course of prednisone along w/my regular prescription.
Thanks for the info!


3 posted on 05/10/2023 12:23:03 PM PDT by telescope115 (My feet are on the ground, and my head is in the stars. A Man, and proud of it!)
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To: ConservativeMind

Dang! I’ve been using a small dose of melatonin before bed for a few weeks, and it REALLY has helped me sleep.

This study mentions issues re colitis. I wonder if it impacts the urinary tract, too, that would make UTIs an issue.


4 posted on 05/10/2023 12:30:03 PM PDT by MayflowerMadam (Worrying doesn't take away tomorrow's troubles. It takes away today's peace.)
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To: telescope115

If someone has colitis, it is likely their bowel bacteria are messed up or missing.


5 posted on 05/10/2023 12:30:46 PM PDT by aMorePerfectUnion (Fraud vitiates everything)
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To: ConservativeMind

Oh yes. Ambien is much better for you.

These pharma shills are so transparent.


6 posted on 05/10/2023 12:31:14 PM PDT by Seruzawa ("The Political left is the Garden of Eden of incompetence" - Marx the Smarter (Groucho))
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To: ConservativeMind

Study only done with mice. Might or might not be valid with humans.

Common sense says that anything like this is probably best when only used as needed.


7 posted on 05/10/2023 12:32:03 PM PDT by Republican in occupied CA (There was enough government in 1789)
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To: aMorePerfectUnion

I was diagnosed with UC 29 years ago. It’s already cost me my original liver.
Autoimmune diseases abound in me..


8 posted on 05/10/2023 12:36:37 PM PDT by telescope115 (My feet are on the ground, and my head is in the stars. A Man, and proud of it!)
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To: ConservativeMind

Just last night I decided to cutback from 12mg to 3mg for other reasons.

But regarding the effect on lower GI microbiome and symptoms, I was at one time practically disabled with non-ulcerative colitis, but the disorder spontaneously disappeared about 25 years ago and has not re-surfaced while using melatonin.


9 posted on 05/10/2023 12:38:52 PM PDT by steve86 (Numquam accusatus, numquam ad curiam ibit, numquam ad carcerem™)
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To: aMorePerfectUnion

“If someone has colitis, it is likely their bowel bacteria are messed up or missing.”

Not necessarily. That is a too broad of a generalization. Colitis can also be caused by CNS activation (”nerves”) and various inflammatory syndromes from microglia releasing inflammatory chemicals on up.


10 posted on 05/10/2023 12:44:25 PM PDT by steve86 (Numquam accusatus, numquam ad curiam ibit, numquam ad carcerem™)
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To: ConservativeMind
I take melatonin nightly, and have been for a couple of years now. (I began during covid because it enhances immune response, but liked the sleep effect so well, I keep taking the supplement.

Maybe because I also take probiotics and fish oil, but I never have any "issues" w gut or colitis.

11 posted on 05/10/2023 12:55:27 PM PDT by Seaplaner (Never give in. Never give in. Never, never, never...in nothing, great or small...Winston Churchill)
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To: steve86

—> CNS activation (”nerves”) and various inflammatory syndromes from microglia releasing inflammatory chemicals

I could theorize how each of those could be activated by poor flora.


12 posted on 05/10/2023 1:41:02 PM PDT by aMorePerfectUnion (Fraud vitiates everything)
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To: steve86

I have no gut problems. Been having probiotic filled yogurt with fruit for dessert every night for years. Plus, I drink Kombucha every night before dinner instead of wine. Kombucha is the best source of probiotics. I like the Mojita flavor, slightly tart like a real Mohita. What’s not to like?


13 posted on 05/10/2023 2:28:28 PM PDT by Veto! (FJB Sucks Rocks)
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To: Seaplaner

I use melatonin almost every night too, found a nice timed-release brand and don’t take a high does, but then, I’m a small woman.

My microbiome is dandy as I eat yogurt for dessert every night and have a glass of Kombucha before dinner instead of wine. Kombucha is the best source of probiotics and comes in many flavors.


14 posted on 05/10/2023 2:34:15 PM PDT by Veto! (FJB Sucks Rocks)
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To: ConservativeMind

Eat enough probiotic yogurt to offset the side effects.


15 posted on 05/10/2023 2:46:29 PM PDT by JimRed (TERM LIMITS, NOW! Militia to the border! TRUTH is the new HATE SPEECH.)
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To: ConservativeMind

I retired five years ago. When I was working, my anxiety levels were off the charts and interfering with sleep. My doc recommended Melatonin probably 15 years ago. I started off with 2 mg which helped and I bumped it up to 5 mg time-release when COVID hit. I’m still on 5 mg nightly. No effects on GI issues that I’m aware of.

No probiotics or kombucha, but I do take Nigella Sativa (black seed oil) plus Krill Oil (Omega 3) every morning. I started the Krill Oil about a month ago. Started the Nigella Sativa when the FLCCC recommended it if you couldn’t get Ivermectin. Since then, they’ve taken that recommendation down.

Between NAC, Vit D, Vit C, Quercetin, Melatonin, zinc, and the two oils, I went four years without a cold. Then one set in 16 days ago and I’m just recovering with a nagging cough. That is the longest stretch I’ve had without a cold in like forever.


16 posted on 05/10/2023 3:18:52 PM PDT by ProtectOurFreedom (I don’t like to think before I say something...I want to be just as surprised as everyone else…)
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To: Veto!

I take Lifeway-brand Kefir two or three times a year if I think I’m having problems down there. Thank you for commenting to me.


17 posted on 05/10/2023 3:34:56 PM PDT by steve86 (Numquam accusatus, numquam ad curiam ibit, numquam ad carcerem™)
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To: Veto!
Good report, thanks much!

(I might vote for a little pre-dinner wine as well, but that's just moi)

18 posted on 05/10/2023 5:33:40 PM PDT by Seaplaner (Never give in. Never give in. Never, never, never...in nothing, great or small...Winston Churchill)
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To: ConservativeMind; All

Antibiotics are what throw the gut bacteria out of whack! To get the gut back in balance, I eat prebiotic yogurt or kefir.
Doctors typically prescribe antibiotics for gut problems and UTI’s, but antibiotics ALWAYS worsen the problem!

As for melatonin, I’ve always heard you shouldn’t take it longer than 2 or 3 nights in a row, to get your circadian sleep rhythms back on track..
Your brain normally produces its own melatonin, which should naturally shut down when the sun comes up, to be replaced by natural serotonin.
If my rhythm is “off” I’ve found that a small dose of melatonin (3 or 6 mg) for 2 or 3 nights can get me back in the habit of falling asleep at my regular bedtime.

But if you take the melotonin supplement every night, it builds up in your body. The result will be daytime sluggishness and/or depression.

Lately I find I don’t even need the melatonin if I wear a blackout eye mask to bed.

Mask on= total darkness= mind shuts down= I’m out in a couple of minutes. Deep, restful sleep.


19 posted on 05/10/2023 5:44:38 PM PDT by mumblypeg ("Give me Stalin or St. Paul. I've seen the Future, brother; it is murder."--Leonard Cohen)
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To: ConservativeMind

bump


20 posted on 05/11/2023 2:41:41 AM PDT by stockpirate (Where Justice Ends Tyranny Begins...Repression Breeds Violence)
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