Posted on 07/20/2023 4:05:05 PM PDT by ConservativeMind
Research found a connection between gut microbiota and distal symmetric polyneuropathy. The team finds a potential causal role of the gut microbiota in distal symmetric polyneuropathy symptoms.
Distal symmetric polyneuropathy (DSPN) is a common, progressive and debilitating neuropathy complication closely associated with diabetes.
While more than half of all patients with diabetes will develop diagnosable DSPN, no effective treatments are available.
The gut microbiota has been implicated in maintaining glucose homeostasis and affecting the nervous system through the gut-brain and neuroimmune-endocrine axes. Previous studies have demonstrated the impact of gut microbiota on neurodegenerative disorders in the central nervous system.
Significant differences in gut microbiota composition have been previously observed in diabetes patients with and without DSPN.
In a randomized, double-blind, placebo-controlled pilot clinical trial, FMT from healthy donors was conducted on 22 human patients with DSPN who responded poorly to conventional treatments. Compared to 10 patients who received a placebo, the results show a significant alleviation of DSPN symptoms after FMT, indicating a potential causal role of the gut microbiota in this disorder.
The study identifies key bacteria that may mediate the protective effect of the gut microbiota in DSPN using a genome-centric and guild-based approach. Two competing guilds of gut bacteria are identified: guild 1, associated with higher capacity in butyrate production and improved gut barrier integrity, and guild 2, associated with more genes in the synthetic pathway of endotoxin. Following FMT, an increase in guild 1 and a decrease in guild 2 are observed, aligning with the alleviation of DSPN.
The study suggests that beneficial effects of FMT on DSPN are not solely mediated through improvements in glycemic control or alterations in certain metabolites. Instead, reducing endotoxin production and increasing the capacity for butyrate production from the gut microbiota may improve gut barrier function and reduce systemic inflammation.
(Excerpt) Read more at medicalxpress.com ...
I will say increasing butyrate production generally comes from encouraging beneficial bacteria already in our gut, via eating various forms of soluble, fermentable fibers, so there might be a more tasty option to accomplish some of the same benefit.
Unfortunately, with the “ferment,” you may also get some gas.
Enjoy!
Kombucha and Kefir Milk. It’s the only way to go.
So… Greek yogurt may offer the same benefits?
No, you need the fiber.
There’s no fiber in normal greek yogurt.
I got an idea, America…. Stop eating like a bunch of pigs at a trough, start working out.
Never has a nation been so fat… and gay… really gay.
I’ll sell you my fecal matter for $1000.
There is a FReeper who sells his poo.
He been pre-approved to do so.
But that wouldn’t be in the fecal matter tho?
Not for me man.... I got all the crap I can handle.!
I will willingly die before I put another human’s poop up my butt.
Well, that deal really stinks..! (no pun intended..well maybe)
They're giving it away for free in DC.... :)
In Gavin’s California you can get it free, just scoop it off the sidewalk.
Well just remember “You get what you pay for”.
This is getting out of hand.
FWIW, this worthless research comes from the land of bat viruses.
There are a number of them selling it. So much so it's become worthless. Nobody is buying it.
Greek Yogurt? No whey! Unfortunately it’s hard to find normal un greeked yogurt recently in some grocery stores.
pfft - I used to think eating high sugar yoplait was good for me :P
What if she’s really cute?
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